Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5 [0.03%]
肥大细胞蛋白酶C和S调控羧肽酶A及天冬氨酸蛋白酶成熟形式MMCP-5的水平
Frida Henningsson,Paul Wolters,Harold A Chapman et al.
Frida Henningsson et al.
Carboxypeptidase A (CPA) is a metalloprotease, residing in the mast cell secretory granules together with chymases and tryptases. Little information is available with respect to the mechanisms that maintain or regulate the levels of stored ...
Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors [0.03%]
选择性而非亲和力优化的合成蛋白酶抑制剂抗转移功效增强
Ingo J Banke,Matthias J E Arlt,Caroline Pennington et al.
Ingo J Banke et al.
Although tumors frequently show elevated protease activities, the concept of anti-proteolytic cancer therapy has lost momentum after failure of clinical trials with broad-spectrum matrix metalloproteinase inhibitors. Thus we need to adapt o...
Comparative Study
Biological chemistry. 2003 Oct-Nov;384(10-11):1515-25. DOI:10.1515/BC.2003.168 2003
Modulation of the activation of extracellular signal-regulated kinase (ERK) and the production of inflammatory mediators by ADP-ribosylation inhibitors [0.03%]
几种ADP核糖基化抑制剂对激活细胞外信号调节激酶(ERK)及促炎介质生成的调制作用
Cécile Le Page,Juana Wietzerbin
Cécile Le Page
ADP-ribosylation is involved in nuclear factor kappaB (NF-kappaB)-dependent gene expression induced by lipopolysaccharide in murine macrophages. Here we have investigated the mechanism by which ADP-ribosylation inhibitors block signaling pa...
Comparative Study
Biological chemistry. 2003 Oct-Nov;384(10-11):1509-13. DOI:10.1515/BC.2003.167 2003
Suboptimal action of NF-kappaB in Fanconi anemia cells results from low levels of thioredoxin [0.03%]
Fanconi贫血患者的核因子κB信号转导减弱是由于硫氧还蛋白水平降低所致
Maria Kontou,Caroline Adelfalk,Monica Hirsch-Kauffmann et al.
Maria Kontou et al.
Electrophoretic mobility shift assays (EMSA) revealed that under standard cell culture conditions NF-kappaB was induced in Fanconi anemia fibroblasts in contrast to control cells. Dithiothreitol, a potent synthetic redox potential-deliverin...
Comparative Study
Biological chemistry. 2003 Oct-Nov;384(10-11):1501-7. DOI:10.1515/BC.2003.166 2003
Aptamers that recognize the lipid moiety of the antibiotic moenomycin A [0.03%]
识别抗生素莫尼卡霉素A脂质部分的适配器分子
Heike Betat,Stefan Vogel,Marc Struhalla et al.
Heike Betat et al.
Moenomycin A is an amphiphilic phosphoglycolipid antibiotic that interferes with the transglycosylation step in peptidoglycan biosynthesis. The antibiotic consists of a branched pentasaccharide moiety, connected to the moenocinol lipid via ...
Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator [0.03%]
大鼠肾源性跨膜型丝氨酸蛋白酶的克隆与鉴定及一种新的钠通道活化剂
Yuushi Okumura,Mai Nishikawa,Ping Cui et al.
Yuushi Okumura et al.
We have cloned the gene of a new transmembrane-type serine protease from rat kidney, which activates sodium channels. The amino acid sequence deduced from a full-length cDNA revealed that transmembrane serine protease-1 (TMSP-1) is a member...
Comparative Study
Biological chemistry. 2003 Oct-Nov;384(10-11):1483-95. DOI:10.1515/BC.2003.164 2003
Molecular recognition between Azotobacter vinelandii rhodanese and a sulfur acceptor protein [0.03%]
Azotobacter vinelandii 栽体酶与硫受体蛋白之间的分子识别
Angelo Cereda,Fabio Forlani,Stefania Iametti et al.
Angelo Cereda et al.
The occurrence of rhodanese-like proteins in the major evolutionary phyla, together with the observed abundance of these proteins also within the same genome, suggests that their function cannot be limited to cyanide scavenging. The aim of ...
Thermodynamic analysis of the dissociation of the aldolase tetramer substituted at one or both of the subunit interfaces [0.03%]
单体界面一个或两个位置被取代的烯醇化酶四聚体离解的热力学分析
Dean R Tolan,Benjamin Schuler,Peter T Beernink et al.
Dean R Tolan et al.
The fructose-1,6-bis(phosphate) aldolase isologous tetramer tightly associates through two different subunit interfaces defined by its 222 symmetry. Both single- and double-interfacial mutant aldolases have a destabilized quaternary structu...
Comparative Study
Biological chemistry. 2003 Oct-Nov;384(10-11):1463-71. DOI:10.1515/BC.2003.162 2003
Gene organization and molecular modeling of copper amine oxidase from Aspergillus niger: re-evaluation of the cofactor structure [0.03%]
烟曲霉铜胺氧化酶的基因组织和分子建模：辅因子结构的再评价
Ivo Frébort,Marek Sebela,Shun Hirota et al.
Ivo Frébort et al.
Amine oxidase AO-I from Aspergillus niger AKU 3302 has been reported to contain topa quinone (TPQ) as a cofactor; however, analysis of the p-nitrophenylhydrazine-derivatized enzyme and purified active site peptides showed the presence of a ...
Immunogenicity and protectivity of Plasmodium falciparum EBA-175 peptide and its analog is associated with alpha-helical region shortening and displacement [0.03%]
疟原虫EBA-175肽及其类物的免疫原性和保护性与α-螺旋区域缩短和错位有关
Adriana Bermúdez,Gladys Cifuentes,Fanny Guzmán et al.
Adriana Bermúdez et al.
EBA-175 protein is used as a ligand in the binding of P. falciparum to red blood cells (RBCs). Evidence shows that the conserved peptide 1779 from this protein (with high red blood cell binding ability and known critical erythrocyte binding...
Comparative Study
Biological chemistry. 2003 Oct-Nov;384(10-11):1443-50. DOI:10.1515/BC.2003.160 2003