Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L [0.03%]
Testican胸腺生成素1型结构域的双重浓度依赖性活性：作为猫淋巴细胞蛋白酶L的特异性抑制剂和底物
Primoz Meh,Miha Pavsic,Vito Turk et al.
Primoz Meh et al.
The thyroglobulin type-1 (Tg-1) domain is a protein module that occurs in a variety of secreted and membrane proteins and is recognised as a potent inhibitor of cysteine peptidases. We present here some properties of the Tg-1 domain of huma...
GRIP1 mediates the interaction between the amino- and carboxyl-termini of the androgen receptor [0.03%]
GRIP1介导雄激素受体氨基末端和羧基末端的相互作用
Howard C Shen,Grant Buchanan,Lisa M Butler et al.
Howard C Shen et al.
The androgen receptor (AR) mediates transactivation of target genes by acting as a dimer in which its amino-terminal domain (AR-NTD) interacts with its carboxyl-terminal, ligand-binding domain (AR-LBD) (N/C interaction). Here we assessed if...
Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3 [0.03%]
兄妹两例钙黏蛋白3号剪接变异IS2区Ser606Leu纯合突变的 limb girdle型肌营养不良症
Dieter E Jenne,Rudi A Kley,Matthias Vorgerd et al.
Dieter E Jenne et al.
Previous family studies revealed a large number of calpain 3 ( CAPN3 ) mutations that cause recessive forms of limb girdle muscular dystrophy (LGMD2A) with selective atrophy of the proximal limb muscles. Correlations between the nature and ...
Case Reports
Biological chemistry. 2005 Jan;386(1):61-7. DOI:10.1515/BC.2005.008 2005
Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病中神经营养素3的转录抑制作用
David A Groneberg,Christian Peiser,Paul R Eynott et al.
David A Groneberg et al.
Chronic obstructive pulmonary disease (COPD) leads to progressive development of airflow limitation and is characterised by cough, mucus hypersecretion and inflammatory changes. These characteristic features of the disease may be modulated ...
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts [0.03%]
恶性疟原虫glyoxalase表征及其与人类同工酶的比较研究
Monique Akoachere,Rimma Iozef,Stefan Rahlfs et al.
Monique Akoachere et al.
The glyoxalase system consisting of glyoxalase I (GloI) and glyoxalase II (GloII) constitutes a glutathione-dependent intracellular pathway converting toxic 2-oxoaldehydes, such as methylglyoxal, to the corresponding 2-hydroxyacids. Here we...
Comparative Study
Biological chemistry. 2005 Jan;386(1):41-52. DOI:10.1515/BC.2005.006 2005
Marcel Deponte,Katja Becker,Stefan Rahlfs
Marcel Deponte
Glutaredoxin-like proteins form a new subgroup of glutaredoxins with a serine replacing the second cysteine in the CxxC-motif of the active site. Yeast Grx5 is the only glutaredoxin-like protein studied biochemically so far. We identified a...
Comparative Study
Biological chemistry. 2005 Jan;386(1):33-40. DOI:10.1515/BC.2005.005 2005
Nitric oxide covalently labels a 6-hydroxydopa-derived free radical intermediate in the catalytic cycle of copper/quinone-containing amine oxidase from lentil seedlings [0.03%]
一氧化氮与豆芽含铜/喹啉的胺氧化酶催化循环中的一种6-羟基多巴衍生自由基中间体共价结合标记
Silvia Longu,Alessandra Padiglia,Jens Z Pedersen et al.
Silvia Longu et al.
The reaction of NO-derivatized polyamines called "NONOates" with an amine oxidase from lentil seedlings was studied. 3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene (DETA-NONOate) and 3,3'-(hydroxynitrosohydrazino)bis-1-propanamine (DPTA-NON...
Purification and characterization of a chitinase-like antifungal protein from black turtle bean with stimulatory effect on nitric oxide production by macrophages [0.03%]
一种刺激巨噬细胞产生一氧化氮的抗真菌蛋白的纯化及特性分析
Kin Tak Chu,Tzi Bun Ng
Kin Tak Chu
An antifungal protein was isolated from black turtle bean, Phaseolus vulgaris cv. "Black Turtle". The purified protein displayed an N-terminal amino acid sequence with 60-80% homology to chitinases. The isolated protein specifically inhibit...
Interaction of thiamin diphosphate with phosphorylated and dephosphorylated mammalian pyruvate dehydrogenase complex [0.03%]
焦磷酸硫胺素与磷酸化和脱磷酸化的哺乳动物丙酮酸脱氢酶复合体的作用关系研究
Xiaoqing Liu,Hans Bisswanger
Xiaoqing Liu
Kinetic and binding studies were carried out on substrate and cofactor interaction with the pyruvate dehydrogenase complex from bovine heart. Fluoropyruvate and pyruvamide, previously described as irreversible and allosteric inhibitors, res...
The structure of the juvenile hormone binding protein gene from Galleria mellonella [0.03%]
家蚕醇磷脂基因结构研究
Agnieszka J Sok,Kamila Czajewska,Andrzej Ozyhar et al.
Agnieszka J Sok et al.
Juvenile hormone (JH) and ecdysone are the key hormones controlling insect growth and development. The juvenile hormone binding protein (JHBP) is the first member in the array of proteins participating in JH signal transmission. In the pres...