Gilles Lalmanach,Elisabeth Diot,Emmanuel Godat et al.
Gilles Lalmanach et al.
Silicosis is an occupational pneumoconiosis caused by inhalation of crystalline silica. It leads to the formation of fibrohyalin nodes that result in progressive fibrosis. Alternatively, emphysema may occur, with abnormal destruction of col...
Structural aspects of recently discovered viral deubiquitinating activities [0.03%]
近期发现的病毒去泛素化活性的结构特点
Traian Sulea,Holger A Lindner,Robert Ménard
Traian Sulea
Protein ubiquitination has been identified as a regulatory mechanism in key cellular activities, and deubiquitination is recognized as an important step in processes governed by ubiquitin and ubiquitin-like modifiers. Viruses are known to t...
Thierry Meinnel,Alexandre Serero,Carmela Giglione
Thierry Meinnel
The N-terminus of any protein may be used as a destabilization signal for targeted protein degradation. In the eukaryotic cytosol, the signal - the so-called N-degron--is recognized for degradation by (i) the N-end rule, a well-described de...
Marguerite S Buzza,Phillip I Bird
Marguerite S Buzza
Granzyme A (GrA) and granzyme B (GrB) play key roles in the induction of target cell death induced by cytotoxic lymphocytes. Whilst these roles have been extensively studied, it is becoming apparent that both granzymes also possess extracel...
Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice [0.03%]
猫溶酶体蛋白酶L和S不是激活二肽基肽酶I( cathepsin C)所必需的
Jon Mallen-St Clair,Guo-Ping Shi,Rachel E Sutherland et al.
Jon Mallen-St Clair et al.
The cysteine protease dipeptidyl peptidase I (DPPI) activates granule-associated immune-cell serine proteases. The in vivo activator of DPPI itself is unknown; however, cathepsins L and S are candidates because they activate pro-DPPI in vit...
Adaptation of the behaviour of an aspartic proteinase inhibitor by relocation of a lysine residue by one helical turn [0.03%]
通过将赖氨酸残基移动一个螺旋周转来调整天冬氨酸蛋白酶抑制剂的行为适应性
Tim J Winterburn,David M Wyatt,Lowri H Phylip et al.
Tim J Winterburn et al.
In addition to self-inhibition of aspartic proteinase zymogens by their intrinsic proparts, the activity of certain members of this enzyme family can be modulated through active-site occupation by extrinsic polypeptides such as the small IA...
Heparin modulation of human plasma kallikrein on different substrates and inhibitors [0.03%]
肝素调节人血浆激肽原酶对不同底物和抑制剂的作用
Andrezza J Gozzo,Viviane A Nunes,Ilana Cruz-Silva et al.
Andrezza J Gozzo et al.
The interplay of different proteases and glycosaminoglycans is able to modulate the activity of the enzymes and to affect their structures. Human plasma kallikrein (huPK) is a proteolytic enzyme involved in intrinsic blood clotting, the kal...
Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma [0.03%]
原发性卵巢癌组织中激肽释放酶蛋白酶间的相关性可能反映了疾病的进程但无尿素酶和抑制因子的影响
Julia Dorn,Nadia Harbeck,Ronald Kates et al.
Julia Dorn et al.
In epithelial ovarian cancer, the high mortality rate is usually ascribed to late diagnosis, since these tumors commonly lack early-warning symptoms, but tumor-associated biomarkers useful for prognosis or therapy response prediction are in...
C-Terminal truncations of syncytin-1 (ERVWE1 envelope) that increase its fusogenicity [0.03%]
截短的-syncytin-1（ERVWE1包膜）可增加其融合活性
Sascha Drewlo,Simone Leyting,Maria Kokozidou et al.
Sascha Drewlo et al.
Syncytin-1, the envelope protein of ERVWE1, an endogenous retrovirus of the HERV-W family, plays an important role in regulating fusion of the placental trophoblast. At least one of its receptors is expressed on a variety of human cell type...
Molecular and functional analysis of new members of the wheat PR4 gene family [0.03%]
小麦PR4基因家族新成员的分子与功能分析
Laura Bertini,Annunziata Cascone,Marina Tucci et al.
Laura Bertini et al.
Five new genes belonging to the pathogenesis-related (PR) 4 family have been cloned and characterised in Triticum aestivum. Two full-length genes, named wPR4e and wPR4f-b, were isolated by library screening, demonstrating the presence of a ...