Studies on the expression of 6S RNA from E. coli: involvement of regulators important for stress and growth adaptation [0.03%]
大肠杆菌6S RNA表达的研究：涉及应激和生长适应的重要调节因子
Thomas Neusser,Nina Gildehaus,Reinhild Wurm et al.
Thomas Neusser et al.
The small bacterial 6S RNA has been recognized as a transcriptional regulator, facilitating the transition from exponential to stationary growth phase by preferentially inhibiting E sigma 70 RNA polymerase holoenzyme transcription. Consiste...
Makoto Kuro-o
Makoto Kuro-o
The klotho gene functions as an aging-suppressor gene that extends life span when overexpressed and accelerates aging-like phenotypes when disrupted in mice. The klotho gene encodes a single-pass transmembrane protein that binds to multiple...
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence [0.03%]
氧化应激条件下RNA结合蛋白对基因转录后调控在细胞衰老中的作用
Kotb Abdelmohsen,Yuki Kuwano,Hyeon Ho Kim et al.
Kotb Abdelmohsen et al.
To respond adequately to oxidative stress, mammalian cells elicit rapid and tightly controlled changes in gene expression patterns. Besides alterations in the subsets of transcribed genes, two posttranscriptional processes prominently influ...
Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs [0.03%]
微小核糖核酸对胰岛素分泌细胞外泌组件表达的调控作用研究进展
Pascal Lovis,Sonia Gattesco,Romano Regazzi
Pascal Lovis
Fine-tuning of insulin secretion from pancreatic beta-cells participates in blood glucose homeostasis. Defects in this process can lead to chronic hyperglycemia and diabetes mellitus. Several proteins controlling insulin exocytosis have bee...
Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s) [0.03%]
猫脑啡肽酶D和β-分泌酶1的活性动力学性质表明有必要寻找其它β-分泌酶候选体enzyme катализатор 反应物 抑制剂
Israel Schechter,Etty Ziv
Israel Schechter
Many studies suggest that BACE 1 is the genuine beta-secretase; however, this is not undisputed. The wild-type (WT) beta-site of the amyloid precursor protein (APP) present in the worldwide population is cleaved very slowly (kcat/Km: approx...
Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen [0.03%]
芽囊霉素V而非芽囊素L、B和K可能从纤溶酶原上释放出类似血管内皮生成抑制素的片段
Luciano Puzer,Nilana M T Barros,Thaysa Paschoalin et al.
Luciano Puzer et al.
Abstract Cathepsin V is a lysosomal cysteine peptidase highly expressed in corneal epithelium; however, its function in the eye is still unknown. Here, we describe the capability of cathepsin V to hydrolyze plasminogen, which is also expres...
HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells [0.03%]
HNF4α通过调控一组基因抑制肾细胞增殖
Karen Grigo,Andrea Wirsing,Belén Lucas et al.
Karen Grigo et al.
Abstract Few genes are known to be involved in renal cell carcinoma (RCC) development and progression. The cell-specific transcription factor hepatocyte nuclear factor 4 alpha (HNF4 alpha) is down-regulated in RCC and we have shown that HNF...
Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue [0.03%]
蛙皮肽pseudin-2和它的[Lys18]取代类似物的胰岛素释放特性
Yasser H A Abdel-Wahab,Gavin J Power,Ming T Ng et al.
Yasser H A Abdel-Wahab et al.
Abstract Pseudin-2 is a cationic alpha-helical peptide that was first isolated from the skin of the paradoxical frog Pseudis paradoxa on the basis of its antimicrobial activity. We have investigated the insulin-releasing properties and cyto...
Secreted human apolipoprotein(a) kringle IV-10 and kringle V inhibit angiogenesis and xenografted tumor growth [0.03%]
人载脂蛋白（a）分泌型第10四铜结构和第五四铜结构可抑制血管发生及异源移植肿瘤生长
Le Shen,Xuewei Zhu,Yan Wang et al.
Le Shen et al.
Abstract Angiogenesis plays an important role in normal physiology of blood vessel growth, but can contribute to the pathogenesis of diseases, such as cancer. A new anti-angiogenic recombinant kringle protein, composed of the fused domains ...
Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function [0.03%]
组织特异性启动子的利用以及KLK5和KLK7编码蛋白的细胞定位表明它们在胰腺外分泌功能中起作用
Ying Dong,Nick Matigian,Tracey J Harvey et al.
Ying Dong et al.
Abstract Tissue kallikrein (kallikrein 1) was first identified in pancreas and is the namesake of the kallikrein-related peptidase (KLK) family. KLK1 and the other 14 members of the human KLK family are encoded by 15 serine protease genes c...