Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s)
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Many studies suggest that BACE 1 is the genuine beta-secretase; however, this is not undisputed. The wild-type (WT) beta-site of the amyloid precursor protein (APP) present in the worldwide population is cleaved very slowly (kcat/Km: approx. 50 m(-1) s(-1)), w... ...
