Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression [0.03%]
大麻素受体1过表达促进肾细胞癌进展
Jianfeng Wang,Yunze Xu,Yun Zou et al.
Jianfeng Wang et al.
Renal cell carcinoma (RCC) is a common urologic tumor with a poor prognosis. Cannabinoid receptor 1 (CB1), which is a G protein-coupled receptor, has recently been reported to participate in the genesis and development of various cancers. H...
The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis [0.03%]
microRNA-196a在肿瘤发生、进展及预后中的作用
Zhen-Yao Chen,Xin Chen,Zhao-Xia Wang
Zhen-Yao Chen
MicroRNAs are a large group of non-coding RNAs that have emerged as regulators of various biological processes, especially carcinogenesis and cancer progression. Recent evidence has shown that microRNA-196a (miR-196a) is upregulated in most...
PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma [0.03%]
PI3K和MAPK途径介导的BDNF/TrkB增加神经母细胞瘤转移的作用
Zhongyan Hua,Xiao Gu,Yudi Dong et al.
Zhongyan Hua et al.
Brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been reported to be associated with poor prognosis in neuroblastoma (NB) patients. Our previous studies indicated that BDNF activation of TrkB induces chemo...
Hedgehog/Gli1 signal pathway facilitates proliferation, invasion, and migration of cutaneous SCC through regulating VEGF [0.03%]
刺猬/Gli1信号通路通过调节VEGF促进皮肤鳞癌的增殖、侵袭和转移
Qian Sun,Jing Bai,Renrong Lv
Qian Sun
Since hedgehog (HH)/Gli1 that contributes to cancer proliferation and metastasis has been masked for decades, the signaling pathway was investigated about its exact role in proliferation and metastasis of cutaneous squamous cell carcinoma (...
Expression profile and prognostic value of SAV1 in patients with pancreatic ductal adenocarcinoma [0.03%]
SAV1在胰腺导管腺癌患者中的表达谱及预后价值
Lei Wang,Yu Wang,Peng-Ping Li et al.
Lei Wang et al.
SAV1 is a human homolog of salvador that contains two protein-protein interaction modules known as WW domains and acts as a scaffolding protein for Hpo and Warts. SAV1 is known to be a tumor suppressor, but its clinical and prognostic impli...
TRPV6 is a prognostic marker in early-stage cervical squamous cell carcinoma [0.03%]
TRPV6是早期宫颈鳞癌的预后标志物
Fei Sun,Lu Xiao,Xin-Xing Jang et al.
Fei Sun et al.
Transient receptor potential vanilloid 6 (TRPV6) has been shown to promote caner proliferation in several solid tumors, leading to unfavorable clinical outcomes. Our study aimed to elucidate the clinical significance of TRPV6 in patients wi...
Methylation in promoter regions of PITX2 and RASSF1A genes in association with clinicopathological features in breast cancer patients [0.03%]
乳腺癌患者PITX2和RASSF1A基因启动子区甲基化与临床病理特征的关系研究
Eva Jezkova,Karol Kajo,Pavol Zubor et al.
Eva Jezkova et al.
Breast cancer is a heterogeneous disease with very different responses to therapy and different length of survival. In many cases, however, the determination of the stage and histopathological characteristics of breast cancer is insufficien...
Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma [0.03%]
Sonic hedgehog信号通路介导肝细胞癌的发生和发展
Heng Cai,Hongxing Li,Jingmin Li et al.
Heng Cai et al.
Although abnormal activation of the sonic hedgehog (Shh) signaling pathway has been demonstrated in human hepatocellular carcinoma (HCC) patients and in most HCC cell lines, the mechanism by which the Shh pathway promotes the development of...
LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway [0.03%]
长链非编码RNA GAS5通过AKT/mTOR信号转导抑制miR-103促进前列腺癌的增殖和进展
Dong Xue,Cuixing Zhou,Hao Lu et al.
Dong Xue et al.
In prior research, evidence has been found for a relation between low exposure of long non-coding RNAs (lncRNAs) and prostate tumor genesis. This study aims to clarify the underlying mechanisms of lncRNA GAS5 in prostate cancer (PCa). In to...
MMP inhibitor Ilomastat induced amoeboid-like motility via activation of the Rho signaling pathway in glioblastoma cells [0.03%]
基底细胞癌中的RHO信号转导途径促进Ilomastat诱导的变形运动
Shaofeng Yan,Hao Xue,Ping Zhang et al.
Shaofeng Yan et al.
Matrix metalloproteinases (MMPs) play the important role in the process of glioblastoma cell invasion through 3D matrices. However, the effects of MMP inhibitors used in the treatment of malignant gliomas are unsatisfactory. The aim of this...