Expression profile and prognostic value of SAV1 in patients with pancreatic ductal adenocarcinoma [0.03%]
SAV1在胰腺导管腺癌患者中的表达谱及预后价值
Lei Wang,Yu Wang,Peng-Ping Li et al.
Lei Wang et al.
SAV1 is a human homolog of salvador that contains two protein-protein interaction modules known as WW domains and acts as a scaffolding protein for Hpo and Warts. SAV1 is known to be a tumor suppressor, but its clinical and prognostic impli...
TRPV6 is a prognostic marker in early-stage cervical squamous cell carcinoma [0.03%]
TRPV6是早期宫颈鳞癌的预后标志物
Fei Sun,Lu Xiao,Xin-Xing Jang et al.
Fei Sun et al.
Transient receptor potential vanilloid 6 (TRPV6) has been shown to promote caner proliferation in several solid tumors, leading to unfavorable clinical outcomes. Our study aimed to elucidate the clinical significance of TRPV6 in patients wi...
Methylation in promoter regions of PITX2 and RASSF1A genes in association with clinicopathological features in breast cancer patients [0.03%]
乳腺癌患者PITX2和RASSF1A基因启动子区甲基化与临床病理特征的关系研究
Eva Jezkova,Karol Kajo,Pavol Zubor et al.
Eva Jezkova et al.
Breast cancer is a heterogeneous disease with very different responses to therapy and different length of survival. In many cases, however, the determination of the stage and histopathological characteristics of breast cancer is insufficien...
Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma [0.03%]
Sonic hedgehog信号通路介导肝细胞癌的发生和发展
Heng Cai,Hongxing Li,Jingmin Li et al.
Heng Cai et al.
Although abnormal activation of the sonic hedgehog (Shh) signaling pathway has been demonstrated in human hepatocellular carcinoma (HCC) patients and in most HCC cell lines, the mechanism by which the Shh pathway promotes the development of...
LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway [0.03%]
长链非编码RNA GAS5通过AKT/mTOR信号转导抑制miR-103促进前列腺癌的增殖和进展
Dong Xue,Cuixing Zhou,Hao Lu et al.
Dong Xue et al.
In prior research, evidence has been found for a relation between low exposure of long non-coding RNAs (lncRNAs) and prostate tumor genesis. This study aims to clarify the underlying mechanisms of lncRNA GAS5 in prostate cancer (PCa). In to...
MMP inhibitor Ilomastat induced amoeboid-like motility via activation of the Rho signaling pathway in glioblastoma cells [0.03%]
基底细胞癌中的RHO信号转导途径促进Ilomastat诱导的变形运动
Shaofeng Yan,Hao Xue,Ping Zhang et al.
Shaofeng Yan et al.
Matrix metalloproteinases (MMPs) play the important role in the process of glioblastoma cell invasion through 3D matrices. However, the effects of MMP inhibitors used in the treatment of malignant gliomas are unsatisfactory. The aim of this...
Snail-activated long non-coding RNA PCA3 up-regulates PRKD3 expression by miR-1261 sponging, thereby promotes invasion and migration of prostate cancer cells [0.03%]
snail诱导的长链非编码RNA PCAT19通过海绵吸附miR-1261正向调节PRKD3表达从而促进前列腺癌细胞侵袭和迁移
Jin-Hua He,Bao-Xia Li,Ze-Ping Han et al.
Jin-Hua He et al.
Rapidly accumulated evidence has shown that long non-coding RNA (lncRNAs) disregulation is involved in human tumorigenesis in many cancers, including prostate cancer (PCa). LncRNAs can regulate essential pathways that contribute to tumor in...
Differential miRNA expression in pleural effusions derived from extracellular vesicles of patients with lung cancer, pulmonary tuberculosis, or pneumonia [0.03%]
肺癌、肺结核或肺炎患者胸腔积液外泌体的微小RNA差异表达谱分析
Jin Lin,Yan Wang,Ye-Qing Zou et al.
Jin Lin et al.
MicroRNAs (miRNAs) have been found to play important regulatory roles in various physiological and pathological processes. MiRNAs also exhibit high stability and are present at high concentrations in human bodily fluids. Consequently, miRNA...
Xiaoting Gu,Chunxiao Lu,Dongxu He et al.
Xiaoting Gu et al.
To define the role of the NOTCH signaling pathway in the development of chemoresistance and the associated epithelial-mesenchymal transition (EMT), we investigated the effect of Notch3 on adriamycin (ADM)-resistant human breast cancer cells...
RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells [0.03%]
RAD51通过自噬调控CHK1稳定性以促进食管鳞癌细胞增殖
Xinyi Zhu,Qiuhui Pan,Nan Huang et al.
Xinyi Zhu et al.
The serine/threonine protein kinase CHK1 has been reported to bind to the recombinase RAD51 and facilitates its assembly in DNA damage sites via phosphorylation. However, the role of RAD51 in regulating the expression of CHK1 has never been...