Standardization of prostate-specific antigen assays: Impact on reference intervals and clinical decision thresholds [0.03%]
前列腺特异性抗原检验标准化对参考区间和临床决策限的影响
Xavier Filella
Xavier Filella
BackgroundProstate-specific antigen (PSA) remains the most widely used biomarker for prostate cancer screening, diagnosis, and monitoring. However, despite decades of standardization efforts, significant inter-assay variability persists, wi...
Digitoxin as a novel synergistic partner of cisplatin in triple-negative breast cancer (TNBC) cells [0.03%]
Digitoxin作为顺铂在三阴性乳腺癌细胞中的新型协同作用伙伴
Sara A Al-Shun,Magdy M Youssef,Farid A Badria
Sara A Al-Shun
BackgroundTriple-negative breast cancer (TNBC) remains clinically challenging due to its aggressive nature, high recurrence rate, and lack of targeted therapies. To address these limitations, combination chemotherapies that synergistically ...
Kateryna Maslova,Magdalena Chechlinska,Irmina Maria Michalek et al.
Kateryna Maslova et al.
BackgroundTumour biomarkers have become increasingly important in oncology, shaping cancer diagnostics, classification, and patient management. Despite their potential, the use of cancer biomarkers in clinical settings remains limited.Objec...
An integrated bioinformatics and multi-omics investigation of the sirtuin family to identify their prognostic importance in human cancers [0.03%]
结合生物信息学和多种组学对沉默信息调节因子家族的研究以识别其在人类癌症中的预后价值
Md Shahedur Rahman,Rizone Al Hasib,Md Rezanur Rahman et al.
Md Shahedur Rahman et al.
BackgroundIn recent years, the significance of sirtuins in cancer biology has become increasingly evident, but their molecular mechanisms and prognostic impacts remain elusive.ObjectiveThe present study aimed to investigate the differential...
Osteopontin-c gene expression and subcellular localization in ovarian cancer cells: Implications for prognosis and therapeutic responses [0.03%]
卵巢癌细胞中骨桥蛋白基因表达及亚细胞定位与预后和治疗反应的关系研究
Mariana Concentino Menezes Brum,Annie Cristhine Moraes Sousa Squiavinato,Luciana da Torre Carneiro et al.
Mariana Concentino Menezes Brum et al.
BackgroundOsteopontin is a glycophosphoprotein aberrantly expressed in several tumor types, which exhibits several isoforms generated by post-translational and post-transcriptional mechanisms, including alternative splicing. Among total ost...
Asporin increases the extracellular matrix cross-links and inhibits the cancer cell migration [0.03%]
Asporin增加细胞外基质交联并抑制癌细胞迁移
Kimberly Hernandez,Caitlin H Nguyen,Girdhari Rijal
Kimberly Hernandez
BackgroundMigrating strategies of the triple-negative breast cancer (TNBC) together with its role in the establishment of tumor microenvironment (TME), supporting metastasis, have been extensively studied. Extracellular matrix (ECM) is a ma...