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PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma

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Brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been reported to be associated with poor prognosis in neuroblastoma (NB) patients. Our previous studies indicated that BDNF activation of TrkB induces chemo-resistance through ... ...