Targeting glucagon signaling in metabolic disorders, functional insights from zebrafish receptor knockouts [0.03%]
代谢障碍中靶向胰高血糖素信号的启示：来自斑马鱼受体敲除模型的功能研究
Ashraf Al Madhoun,Md Zubbair Malik,Shaima Al-Beloushi et al.
Ashraf Al Madhoun et al.
Glucagon receptor (GCGR) signaling is essential for glucose and lipid homeostasis, making it a potential therapeutic target for metabolic disorders. Zebrafish possess two GCGR co-orthologs, GCGRa and GCGRb, however, their distinct function ...
Posttranslational modifications of AMPA receptors in synaptic function and memory [0.03%]
AMPARs的泛翻译修饰在突触功能和记忆中的作用
Cristina A Muñoz de León-López,Irene Navarro-Lobato,Zafar U Khan
Cristina A Muñoz de León-López
AMPA receptors, members of the ionotropic glutamate receptor family, are the principal mediators of fast excitatory synaptic transmission in the brain, and their trafficking to and from synapses is critical for neuronal communication. AMPA ...
Chronic hypoxia protects the mouse heart from oxidative stress via HIF-1α-mitochondria crosstalk [0.03%]
慢性缺氧通过HIF-1α-线粒体信号交叉保护小鼠心脏免受氧化压力损伤
Barbora Opletalova,Lukas Alan,Miroslav Ferko et al.
Barbora Opletalova et al.
Adaptation to chronic hypoxia (CH) enhances myocardial tolerance to ischemia/reperfusion injury and is closely associated with stabilization of hypoxia-inducible factor-1 alpha (HIF-1α), a central transcription factor in hypoxic response. ...
USP11 alleviates pathological cardiac hypertrophy via stabilizing SIRT6 [0.03%]
USP11通过稳定SIRT6来缓解病理性心脏肥大
Xijia Wang,Wenzhe Zong,Di Zhou et al.
Xijia Wang et al.
Background: Pathological cardiac hypertrophy is a key precursor to heart failure. Protein ubiquitination and deubiquitination are crucial mechanisms controlling cardiomyocyte signaling homeostasis. USP11, a ubiquitin-spec...
Participation of the purinergic P2X7 receptor in molecular complexes in the nucleus of human chondrocytes [0.03%]
人软骨细胞核中P2X7嘌呤能受体参与的分子复合物的作用
Elisabetta Lambertini,Letizia Penolazzi,Anna Chierici et al.
Elisabetta Lambertini et al.
In addition to the purinergic receptor P2X7R's known activity as a sensor of damage-associated molecular patterns (DAMPs), evidences support its role in maintaining tissue homeostasis. Its presence in cellular compartments other than its us...
TMEM16E-mediated macropinocytosis promotes cell survival under acidic stress [0.03%]
TMEM16E介导的巨胞饮作用可促进酸性压力下的细胞存活
Jung-Eun Kim,Byoung-Cheol Lee,Byung-Chang Suh
Jung-Eun Kim
TMEM16E is a transmembrane protein that functions both as a phospholipid scramblase and a non-selective ion channel, playing a critical role in cellular ion transport and membrane dynamics. Recent studies have shown that the TMEM16E scrambl...
Ovarian localization drives IL-7R-dependent CD8 coreceptor expression in peripheral double-negative T cells [0.03%]
卵巢定位驱动外周双阴性T细胞中IL-7R依赖的CD8协同受体表达
Toni Martin,Howard A Young,Enitome E Bafor
Toni Martin
The ovary is an immunologically dynamic tissue that coordinates recurrent inflammation-like remodeling while preserving local T cell tolerance, yet whether it actively instructs infiltrating lymphocyte phenotype or passively enriches pre-ex...
RNF34 restrains endometriosis through SREBP1-dependent metabolic-immune crosstalk [0.03%]
RNF34通过SREBP1依赖的代谢免疫相互作用抑制子宫内膜异位症
Chenjing Yue,Zilong Li,Mengze Wang et al.
Chenjing Yue et al.
Endometriosis is a chronic inflammatory disease with cancer-like features, yet the mechanisms linking metabolic dysregulation to immune remodeling during lesion progression remain poorly understood. Here, we identify the ubiquitin E3 ligase...
ZFP91 restricts RSV replication by driving K48-linked ubiquitination and proteasomal degradation of M2-1 [0.03%]
ZFP91通过促进M2-1的K48连接泛素化和蛋白酶体降解来限制RSV复制
Yufeng Wang,Peijie Zhu,Fei Xu et al.
Yufeng Wang et al.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in children. Among viral components, the M2-1 protein is essential for efficient transcription and replication. Given its pivotal role in the viral...
Venom composition of the ant Tetraponera rufonigra reveals insights into the evolution of dimeric ant venom peptides [0.03%]
蚂蚁Tetraponera rufonigra的毒液组成揭示了二聚体蚁毒肽进化的见解
Suwatjanee Naephrai,Hue N T Tran,Thomas Durek et al.
Suwatjanee Naephrai et al.
The majority of ant species are venomous, and in most lineages, peptide toxins dominate venom composition. Here we investigated the venom of the ant Tetraponera rufonigra (subfamily Pseudomyrmecinae). The major active component, Tr1a, is a ...