One-Pot Synthesis of Phenylboronic Acid-Based Microgels for Tunable Gate of Glucose-Responsive Insulin Release at Physiological pH [0.03%]
用于生理pH值下可调门的葡萄糖响应型胰岛素释放的苯基硼酸基微凝胶的一锅合成法
Prashun G Roy,Jiangtao Zhang,Koushik Bhattacharya et al.
Prashun G Roy et al.
Glucose-responsive insulin delivery systems that effectively regulate insulin retention and release in response to real-time fluctuation of glucose levels are highly desirable for diabetes care with minimized risk of hypoglycemia. Herein, w...
Cooperatively Catalyzed Activation of Thioglycosides with Iodine and Iron(III) Trifluoromethanesulfonate [0.03%]
碘和三氟甲磺酸铁协同催化硫苷类化合物的活化反应
Ashley R Dent,Aidan M DeSpain,Alexei V Demchenko
Ashley R Dent
Reported herein is a further expansion of the cooperatively catalyzed Koenigs-Knorr glycosylation reaction, known as "the 4K reaction". It has been discovered that molecular iodine, along with a metal salt and an acid additive, can activate...
Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer's Disease [0.03%]
欧米伽3脂肪酸的神经保护作用：对抗阿尔茨海默病
Mervin Chávez-Castillo,María Paula Gotera,Pablo Duran et al.
Mervin Chávez-Castillo et al.
Alzheimer's disease (AD) is one of the main causes of dementia, with an exponential increment in its incidence as years go by. However, since pathophysiological mechanisms are complex and multifactorial, therapeutic strategies remain inconc...
Ap4A in Cancer: A Multifaceted Regulator and Emerging Therapeutic Target [0.03%]
癌症中的Ap4A：一个具有多面调控作用的新兴治疗靶点
Kateryna Tkachenko,Tiziana Bachetti,Camillo Rosano
Kateryna Tkachenko
Diadenosine polyphosphates, including diadenosine tetraphosphate (Ap4A), are ubiquitous nucleotides that are present across diverse life forms, gaining considerable interest due to their role as cellular signaling molecules. Ap4A, in partic...
Carboxylated Mesoporous Carbon Nanoparticles as Bicalutamide Carriers with Improved Biopharmaceutical and Chemo-Photothermal Characteristics [0.03%]
羧基化介孔碳纳米颗粒作为比卡鲁胺载体改善其生物医药和化疗光热特性
Teodora Popova,Borislav Tzankov,Marta Slavkova et al.
Teodora Popova et al.
Prostate cancer is a serious, life-threatening condition among men, usually requiring long-term chemotherapy. Due to its high efficacy, bicalutamide, a non-steroidal anti-androgen, has widespread use. However, its poor water solubility, low...
Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc [0.03%]
姜黄素对结肠癌细胞中甲基转移酶/脱甲基酶表达的调节作用：对wt p53，mutp53和c-Myc的影响
Roberta Santarelli,Claudia Di Dio,Michele Di Crosta et al.
Roberta Santarelli et al.
Curcumin-mediated anti-cancer properties have been correlated with the inhibition of oncogenic molecules such as mutp53 and c-Myc. Their targeting is therapeutically significant, as p53, following point mutations, can acquire oncogenic func...
Correction: Marrero et al. Kallopterolides A-I, a New Subclass of seco-Diterpenes Isolated from the Southwestern Caribbean Sea Plume Antillogorgia kallos. Molecules 2024, 29, 2493 [0.03%]
马雷罗等关于卡拉opterolides A-I的研究更正：从西南加勒比海的海羽扇珊瑚Antillogorgia kallos中分离出的一类新的seco-二萜分子。《分子》2024年第29卷第2493号
Jeffrey Marrero,Luis A Amador,Ivan M Novitskiy et al.
Jeffrey Marrero et al.
Text Correction [...].
Published Erratum
Molecules (Basel, Switzerland). 2025 Jul 11;30(14):2929. DOI:10.3390/molecules30142929 2025
Correction: Hoyos-Orozco et al. Synthesis of Imidazolidin-2-ones from trans-(R, R)-Diaminocyclohexane: A Statistical Analysis-Based Pseudo-Multicomponent Protocol. Molecules 2025, 30, 1415 [0.03%]
霍亚斯-奥罗兹科等人的更正：从反式-(R,R)-二氨基环己烷合成咪唑烷-2-酮：基于统计分析的伪多组分协议分子2025，30，1415
Catalina Hoyos-Orozco,Lili Dahiana Becerra,Diego Quiroga
Catalina Hoyos-Orozco
In the original publication [...].
Published Erratum
Molecules (Basel, Switzerland). 2025 Jul 8;30(14):2890. DOI:10.3390/molecules30142890 2025
Drug-Resistant Cholangiocarcinoma Cell Lines for Therapeutic Evaluation of Novel Drugs [0.03%]
用于新药疗效评估的耐药胆管癌细胞系
Kevin Delgado-Calvo,Elisa Lozano,Oscar Briz et al.
Kevin Delgado-Calvo et al.
The pharmacological treatment of cholangiocarcinoma (CCA) is often hampered by tumor resistance. Improving our understanding of this issue is crucial for developing strategies that can overcome drug refractoriness. We have established and c...
Homo- Versus Hetero- [2+2+2] Rhodium-Catalyzed Cycloaddition: Effect of a Self-Assembled Capsule on the Catalytic Outcome [0.03%]
均相与异相[2+2+2]环加成反应：主体包结对催化结果的影响
Maxime Steinmetz,David Sémeril
Maxime Steinmetz
The cationic chloro-P-{[4-(diphenylphosphanyl)phenyl]-N,N-dimethylmethanammonio(norbornadiene)rhodium(I) complex was encapsulated inside a self-assembled hexameric capsule. This capsule was obtained through a reaction involving 2,8,14,20-te...