Biocompatibility of Genetically-Engineered Pig Cornea in Corneal Xenotransplantation: Preliminary In Vitro Study [0.03%]
基因工程猪角膜异种移植的生物相容性：初步体外研究
Seung Hyeun Lee,Chung Young Kim,Jin Suk Ryu et al.
Seung Hyeun Lee et al.
Introduction: We aimed to evaluate biophysical compatibility of corneal endothelial cells in genetically-engineered (GE) pigs to identify the best candidate for in vivo nonhuman primate (NHP) study and to collect baseline...
Initiating Xenotransplantation in India: Foundations, Challenges, and the Road Ahead [0.03%]
在印度开展异种移植：基础、挑战与未来之路
Pranjal Kashiv,Manish Balwani,Amit Pasari et al.
Pranjal Kashiv et al.
Correction to "Defect in Sensing Human Thrombin by Porcine Endothelial Protease-Activated Receptor-1: Molecular Incompatibility between Porcine PAR-1 and Human Thrombin" [0.03%]
对“猪内皮酶激活受体PAR-1感觉人类凝血酶缺陷：猪PAR-1与人凝血酶在分子上的不相容性”的更正
Published Erratum
Xenotransplantation. 2025 Sep-Oct;32(5):e70066. DOI:10.1111/xen.70066 2025
Addressing Racial Disparities in Xenotransplantation Acceptance: A Call for Deeper Societal Understanding [0.03%]
应对种族差异影响异种移植接受率的呼吁：呼唤更深层次的社会理解
Luz A Padilla,Daniel J Hurst
Luz A Padilla
Single-Cell RNA Analysis Reveals Reduced Frequency and Activity of CXCR5+ Atypical Memory B Cells in Islet Xenotransplantation Treated With Clinically Applicable Immunosuppressants Including Belimumab [0.03%]
单细胞RNA分析揭示了CXCR5+非典型记忆B细胞在临床适用免疫抑制剂治疗的胰岛异种移植中的频率和活性降低
Yuji Lee,Ji Hwan Moon,Hyun Je Kim et al.
Yuji Lee et al.
Background: Porcine-to-human islet xenotransplantation offers a promising solution to type 1 diabetes. This study investigates the use of Belimumab, a human monoclonal antibody that inhibits B cell activating factor (BAFF...
Assessment of Porcine Endogenous Retrovirus Infectivity to Human Cells Using Flowcytometric Isolation After Co-Culture [0.03%]
共培养后流式细胞仪分离测定人外周血单个核细胞感染猪内源性逆转录病毒的能力
Hiroto Miura,Haruka Uryu,Shodai Ishikawa et al.
Hiroto Miura et al.
Pigs have been utilized as the donor animal for xenotransplantation, a promising solution to the continued shortage of organ donor. However, porcine endogenous retrovirus (PERV), a gamma retrovirus present in all pig genomes, remains a majo...
Human Hematopoietic Stem Cell Engraftment and Differentiation in Immunodeficient Pigs [0.03%]
免疫缺陷猪体内人造血干细胞的植入及分化
Chen-Chen Pi,Jun Zou,Minghui Fang et al.
Chen-Chen Pi et al.
Immunodeficient large animals that allow engraftment of human tissues and cells are highly valuable for translational studies. Recently, a strain of immunodeficient pigs (termed RGD pigs) was developed through the genetic inactivation of RA...
Porcine Cytomegalovirus/Porcine Roseolovirus (PCMV/PRV) and Antiviral Drugs [0.03%]
猪巨细胞病毒/玫瑰疹病毒(PCMV/PRV)与抗病毒药物
Joachim Denner
Joachim Denner
Kasra Shirini,Joseph M Ladowski,Raphael P H Meier
Kasra Shirini
From January to June 2025, the field of xenotransplantation progressed rapidly toward clinical translation, with landmark compassionate-use cases, peer-reviewed reports of porcine kidney, heart, and liver transplants in humans, and the rele...