Porcine Expanded Potential Stem Cells as a Versatile Platform for Multiplex Genome Editing and Immunophenotyping in Xenotransplantation [0.03%]
用于异种移植的猪多基因组编辑和免疫表型鉴定的多功能平台细胞
Yiyi Xuan,Yong Xiang,Xining Wang et al.
Yiyi Xuan et al.
Xenotransplantation utilizing pig donors offers a promising solution to organ shortages, but immune incompatibilities across species remain a major challenge. Current reliance on porcine primary fibroblasts for genome editing is limited by ...
The Potential Role of Expression of HLA-E and HLA-G in Organ Xenotransplantation [0.03%]
HLA-E和HLA-G表达在器官异种移植中的潜在作用
Jeffrey K Sumbo,Xiaowei Hu,Eckhard Wolf et al.
Jeffrey K Sumbo et al.
Xenotransplantation offers a promising solution to the shortage of human organs for transplantation but requires overcoming numerous immune responses-particularly those mediated by the innate immune system through natural killer (NK) cells ...
Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update [0.03%]
全球临床异种移植咨询会议：国际异种移植协会共识和公报更新
Wayne J Hawthorne,Eckhard Wolf,Peter J Cowan et al.
Wayne J Hawthorne et al.
Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Ass...
Beyond the Transplanted: Who Should Inform Attitudes Toward Xenotransplantation? [0.03%]
超越移植：谁应影响异种移植的态度？
Jenny L McDonnell,Tony O Pomales,Tomohiro Tanaka
Jenny L McDonnell
A Review of Informed Consent for Porcine Islet Xenotransplantation to Treat Type 1 Diabetes [0.03%]
评述告知同意在猪胰岛异种移植治疗1型糖尿病中的应用
Jennifer Kovalcik,Sheetal Mohanty,Mairead Higgins et al.
Jennifer Kovalcik et al.
Purpose: The objective of this review is to map and synthesize the existing literature regarding informed consent for porcine islet xenotransplantation for the treatment of Type 1 Diabetes. ...
Perspectives of Patients on the Kidney Transplant Waitlist Regarding Willingness to Undergo Xenotransplantation [0.03%]
终末期肾病患者异种移植接受度及其影响因素
Joseph M Ladowski,Isabel DeLaura,Imran J Anwar et al.
Joseph M Ladowski et al.
Background: Xenotransplantation, the use of genetically modified pigs as organ donors, is entering clinical trials in kidney transplantation. Although the medical community has long considered xenotransplant a potential s...
Public-Facing Media Characterizations of Contemporary First-in-Human Xenotransplants in the United States: A Qualitative Content Analysis [0.03%]
美国公共媒体对当代人体首次异种移植的描述：定性内容分析
Jordan Liebman,Amanda Zink,Tia Ketsan et al.
Jordan Liebman et al.
Introduction: Media messaging offers insight into the informational context that may shape the public's acceptance of xenotransplantation (XTx). The purpose of this study was to characterize the media's portrayal of the i...
Combined Islet and Kidney Xenotransplantation for Diabetic Nephropathy: Investigation of Pre-Vascularized Composite Grafts versus Sequential Islet-After-Kidney Transplantation in a Pig-to-Nonhuman Primate Model of Xenotransplantation [0.03%]
结合了胰岛和肾脏的异种移植治疗糖尿病肾病：在一个非人灵长类动物的异种移植模型中研究前血管化复合移植物与依次进行的胰岛-肾脏移植的区别
Alexander C Schulick,Daniel L Eisenson,WeiLi Chen et al.
Alexander C Schulick et al.
Aims: Combined renal and islet xenotransplantation could provide a durable treatment for end-stage diabetic nephropathy. In this feasibility-focused study, we evaluated two complementary approaches for clinical translatio...
Daniel J Hurst,Alexa Tarzy,Christopher A Bobier et al.
Daniel J Hurst et al.
For the management of type 1 diabetes, islet xenotransplantation has emerged as a potential alternative to lifelong insulin therapy or islet allotransplantation. However, this progress raises significant ethical questions that warrant furth...
David K C Cooper,Hidetaka Hara,Zuhui Pu et al.
David K C Cooper et al.
Since January 2022, eleven clinical xenotransplants into living patients involving gene-edited pig hearts (n = 2) or kidneys (n = 9) have provided initial data on patient selection, organ sourcing, and immunosuppression. Lessons from cardia...