Joachim Denner
Joachim Denner
As clinical trials in xenotransplantation commence, the question of whether participants may withdraw from research is being intensely debated. Some authors argue that xenotransplant recipients should be subject to lifelong monitoring becau...
Integrated Multi-Omics Analysis of Coagulation Dysregulation and Immune Pathway Alterations in 10-Gene Pig-to-Monkey Liver Xenotransplantation: A Case Report [0.03%]
Wei Zhang,Rongrong Wang,Xuan Zhang et al.
Wei Zhang et al.
Liver xenotransplantation has the potential to address the global shortage of donor organs; however, coagulation dysregulation remains a predominant barrier to long-term liver xenograft survival. In this study, orthotopic liver xenotranspla...
Case Reports
Xenotransplantation. 2026 May-Jun;33(3):e70132. DOI:10.1111/xen.70132 2026
Precise Multi-Gene Editing Strategies for Xenotransplantation Donor Pigs: Overcoming Immune and Coagulation Barriers [0.03%]
精准的多基因编辑策略制备异种移植供体猪：克服免疫和凝血障碍
Qianqian Li,Jingchao Cao,Shoulong Deng et al.
Qianqian Li et al.
Organ transplantation is the preferred treatment for end-stage organ failure, but the severe shortage of donors severely restricts its clinical application. Xenotransplantation, especially using pigs as donors, is considered an ideal source...
Clinical Pig Kidney Xenotransplantation Rewrites the Rules of Renal Graft Rejection [0.03%]
临床猪肾异种移植改写了肾脏移植排斥的规则
Wen-Bin Liu,Hong-Liang Rui,Bao-Li Liu
Wen-Bin Liu
The recent milestone publication by Schmauch et al. in Nature (650 (2026): 205-217) describes a 61-day longitudinal multi-omics analysis of a gene-edited pig-to-human kidney xenotransplant in a brain-dead decedent. This study provides an un...
Renin-Angiotensin-Aldosterone System (RAAS) in Pig-to-Baboon Kidney Xenotransplantation-Relevance to Clinical Pig Kidney Xenotransplantation [0.03%]
猪肾异种移植到狒狒模型中的肾素-血管紧张素-醛固酮系统(RAAS)与临床 pig 肾脏异种移植的相关性研究
Maho Terashita,Kohei Kinoshita,Ryousuke Satou et al.
Maho Terashita et al.
Background: Pig-to-human kidney xenotransplantation offers a potential solution to the organ shortage. However, the ability of the transplanted pig kidney to regulate blood pressure and fluid balance remains uncertain. Th...
"Will I Still be Myself?" Opposition to Xenotransplantation Among Chinese Kidney Transplant Candidates: A Qualitative Study [0.03%]
“我还将是我本人吗？”中国器官移植受者对于跨物种器官移植的反对意见——一项定性研究
Wenhao Tang,Jiaxing Zhou,Shangping Zhao et al.
Wenhao Tang et al.
Background: Kidney transplantation remains the preferred treatment for end-stage renal disease (ESRD), yet its application is constrained by a persistent shortage of donor organs. Xenotransplantation has emerged as a prom...
Donor-Derived Cell-Free DNA (dd-cfDNA) as an Early Noninvasive Biomarker of Graft Injury in Pig-to-Monkey Islet Xenotransplantation [0.03%]
猪胰岛异种移植至猴模型中供体来源的细胞游离DNA（dd-cfDNA）作为移植物损伤早期无创生物标志物的研究
Ji-Jing Yan,Jong-Min Kim,Sang-Ik Cho et al.
Ji-Jing Yan et al.
Background: In pig-to-nonhuman primate islet transplantation, reliable, sensitive biomarkers are needed to detect graft damage at an early stage before irreversible islet loss occurs. In our study, we investigated donor-d...
The Emergence of the Asian Xenotransplantation Association: Regional Collaboration in a Rapidly Evolving Field [0.03%]
亚洲异种移植协会的出现：一个迅速发展的领域中的区域合作
Hidetaka Hara,Ik Jin Yun,Yi Wang
Hidetaka Hara
Global progress in xenotransplantation has accelerated following recent first-in-human applications of gene-edited porcine organs. While pioneering clinical experiences have largely been reported from the United States, scientific, translat...
Kasra Shirini,Joseph M Ladowski,Niket Harsh et al.
Kasra Shirini et al.
The second half of 2025 marked a significant transition for xenotransplantation, shifting further from experimental feasibility to early clinical translation. Prolonged physiologic support from genetically engineered porcine kidneys and liv...
CMAH-Targeted Knock-In of Inducible Heme Oxygenase-1 and Constitutive CD47 in GGTA1-Knockout Pigs for Xenotransplantation [0.03%]
用于异种移植的GGTA1基因敲除猪中HO-1条件性表达和CD47组成型表达的CMAH目标敲入研究
Haesun Lee,Sang Eun Kim,Won Kil Lee et al.
Haesun Lee et al.
Background: Pig xenografts offer a solution to human organ shortage; however, immune rejection is a major barrier. Immunomodulatory genes such as heme oxygenase-1 (HO1) and CD47 are key. Precise promoter control and strat...