Realistic Prospects of Xenotransplantation in Japan: Specific Regulations for Clinical Application [0.03%]
日本异种移植的现实前景及其临床应用的具体规定
Kazuki Morita,Yuichiro Ukon,Satoshi Hosoya et al.
Kazuki Morita et al.
Xenotransplantation has emerged as a potential solution to the critical shortage of donor organs, with recent breakthroughs demonstrating transplantation of genetically modified porcine organs into humans. In Japan, the Ministry of Health, ...
Aaron C K Lucander,David K C Cooper
Aaron C K Lucander
Whole blood and its constituents are primary treatments for numerous human patients with a vast array of clinical conditions. Each year, these include >10 million blood transfusions performed in the USA and approximately 16 million patients...
Investigational New Drug Enabling Nonclinical Study of Xenogeneic Life-Supporting Porcine Kidneys With 10 Gene Edits (10 GE) in a Nonhuman Primate Test System [0.03%]
一种新型 investigational new drug (IND) 启动的非人灵长类动物实验系统研究：具有十种基因编辑(xenogeneic life-supporting porcine kidneys with 10 gene edits (10 GE)) 的异种生命支持猪肾脏的非临床研究
Daniel L Eisenson,Alexander C Schulick,WeiLi Chen et al.
Daniel L Eisenson et al.
This Investigational New Drug (IND) enabling study evaluated life-supporting kidney xenotransplantation using porcine source animals with 10 gene edits (10 GE) in a nonhuman primate (NHP) test system. Twelve baboons received xenografts with...
Human CD64 Alleviates Antibody-Mediated Rejection in Xenotransplantation [0.03%]
人源CD64可缓解异种移植中的抗体介导的排斥反应
Chuheng Gou,Hong Zhang,Rui Ding et al.
Chuheng Gou et al.
Background: Xenotransplantation, using gene-edited pigs, represents an important approach to overcoming human organ shortages. A major obstacle to xenotransplantation is antibody-mediated rejection (AMR), which leads to x...
Genomic Validation of PERV-C-Free Pigs to Support Xenotransplantation [0.03%]
用于异种移植的PERV-C阴性基因编辑猪的全基因组验证研究
Neal R Benjamin,Giovanni Madrigal,Yasuko Ishida et al.
Neal R Benjamin et al.
Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV-A, -B, and -C, which differ in their host range. PERV-A and -B can infect human ...
A Report of Four Depletional Induction Strategies in Non-Human Primate Islet Xenotransplantation [0.03%]
四种消耗性诱导策略在非人灵长类动物胰岛异种移植中的报告
Meghan Hu,Qimeng Gao,Joseph Ladowski et al.
Meghan Hu et al.
Background: Porcine islet xenotransplantation is limited by the availability of clinically applicable immunosuppressive regimens. We tested four depletional induction strategies and maintenance regimens in a non-human pri...
Functional Xenogeneic Liver Support in a Living Human: Promise, Lessons, and Next Steps [0.03%]
功能性异种肝脏支持在活体人体中的应用：前景、教训和下一步措施
Raphael P H Meier
Raphael P H Meier
Genetically engineered porcine organs are redefining the boundaries of clinical xenotransplantation. Zhang et al. now report the first functional pig-to-human liver xenotransplantation in a living patient, demonstrating that a 10-gene-edite...
Global Research Trends and Current Status of Xenotransplantation: A Bibliometric Analysis [0.03%]
全球异种移植研究进展及现状的文献计量分析
Shujun Yang,Xilong Lin,Hao Wei et al.
Shujun Yang et al.
Xenotransplantation has garnered significant attention in recent years, characterized by substantial progress and rapid developments within the field. The objective of this study was to investigate the evolving trends and emerging research ...
What Kind of Social Preparations Are Needed for Xenotransplantation? A Survey Study of the Japanese General Public [0.03%]
日本公众异种移植社会接纳状况及其影响因素调查研究
Ayako Kamisato,Satoshi Hosoya
Ayako Kamisato
Introduction: With the advent of genome editing technology, xenotransplantation has been attracting attention in recent years as a potential solution to the shortage of organs for transplantation. In Japan, several Japane...
Pilot Study: Functional Survival of Human Stem Cell-Derived Islets Microencapsulated With Alginate Incorporating CXCL12 in Non-Human Primates Without Systemic Immunosuppression [0.03%]
不用全身免疫抑制的微型封装Cxcl12藻酸盐人干细胞来源导管岛细胞在非人灵长类动物的功能性存活研究
Kento Kawai,Fatma Dogan,David A Alagpulinsa et al.
Kento Kawai et al.
Glucose-responsive insulin-secreting stem cell-derived islet-like cells (SC-islets) are a promising source for beta cell replacement to treat type 1 diabetes (T1D). However, immune rejection and limited function of SC-islets post-transplant...