Peter Choong
Peter Choong
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST [0.03%]
条件性失活Pten并过度表达EGFR的雪旺细胞可模拟散发性的MPNST
Vincent W Keng,Adrienne L Watson,Eric P Rahrmann et al.
Vincent W Keng et al.
The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1- (NF1-)associated or sporadic malignant peripheral nerve sheath tumors (MPNSTs) remain unclear...
Comparison of Surface Area across the Allograft-Host Junction Site Using Conventional and Navigated Osteotomy Technique [0.03%]
传统与导航截骨技术下人工移植骨-宿主骨结合部位接触面积的对比研究
Ajay Lall,Eric Hohn,Mimi Y Kim et al.
Ajay Lall et al.
Bulk allograft reconstruction plays an important role in limb-salvage surgery; however, non-union has been reported in up to 27% of cases. The purpose of this study is to quantify average surface contact areas across simulated intraoperativ...
David Roberge,Siavosh Vakilian,Yazan Z Alabed et al.
David Roberge et al.
Soft-tissue sarcomas spread predominantly to the lung and it is unclear how often FDG-PET scans will detect metastases not already obvious by chest CT scan or clinical examination. Adult limb and body wall soft-tissue sarcoma cases were ide...
Survival trends and long-term toxicity in pediatric patients with osteosarcoma [0.03%]
儿童骨肉瘤患者的生存趋势和长期毒性反应
Melanie M Hagleitner,Eveline S J M de Bont,D Maroeska W M Te Loo
Melanie M Hagleitner
Background. This study was conducted to investigate the clinical characteristics and treatment results of osteosarcoma in pediatric patients during the past 30 years. Trends in survival rates and long-term toxicity were analyzed. Procedure....
Yoshiyuki Suehara,Daisuke Kubota,Kazutaka Kikuta et al.
Yoshiyuki Suehara et al.
Osteosarcomas are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel ther...
Nathalie Gaspar,Angela Di Giannatale,Birgit Geoerger et al.
Nathalie Gaspar et al.
Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults. With the current therapies, some patients remain very difficult to treat, such as tumour with poor histo...
Genes regulated in metastatic osteosarcoma: evaluation by microarray analysis in four human and two mouse cell line systems [0.03%]
转移性骨肉瘤的基因调控：四种人细胞系和两种小鼠细胞系微阵列分析评估结果
Roman Muff,Ram Mohan Ram Kumar,Sander M Botter et al.
Roman Muff et al.
Osteosarcoma (OS) is a rare bone neoplasm that affects mainly adolescents. It is associated with poor prognosis in case of metastases formation. The search for metastasis predicting markers is therefore imperative to optimize treatment stra...
β-Catenin Does Not Confer Tumorigenicity When Introduced into Partially Transformed Human Mesenchymal Stem Cells [0.03%]
部分转化的人间充质干细胞转入β-连环蛋白后不具备致瘤性
Sajida Piperdi,Lukas Austin-Page,David Geller et al.
Sajida Piperdi et al.
Although osteosarcoma is the most common primary malignant bone tumor in children and adolescents, its cell of origin and the genetic alterations are unclear. Previous studies have shown that serially introducing hTERT, SV40 large TAg, and ...
A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells [0.03%]
IGF1在Ewing肉瘤细胞中介导凋亡的新型作用机制研究
Frans van Valen,Henning Harrer,Marc Hotfilder et al.
Frans van Valen et al.
Insulin-like growth factor 1 (IGF1) reputedly opposes chemotoxicity in Ewing sarcoma family of tumor (ESFT) cells. However, the effect of IGF1 on apoptosis induced by apoptosis ligand 2 (Apo2L)/tumor necrosis factor (TNF-) related apoptosis...