K K Wang
K K Wang
Recent advances in the elucidation of the biochemical machinery of apoptosis have allowed us to appreciate the significance of unscheduled apoptosis in a wide range of human diseases and disorders, such as ischemic stroke, traumatic brain i...
J P O&#x;Bryan
J P O&#x;Bryan
The convergence of cell biology, virology, biochemistry, molecular biology and genetics, has resulted in an increased understanding of the mechanisms by which cells communicate with each other and their environment. It has become clear that...
D Ricquier
D Ricquier
The mechanisms explaining the imperfect coupling of respiration to ADP phosphorylation in mitochondria are not well understood. In the case of a thermogenic organ such as brown adipose tissue, heat production results from a regulated uncoup...
The role of corticotropin-releasing factor and its receptors in the central nervous system [0.03%]
脑室内注射CRF对大鼠抑郁样行为及血浆皮质酮的影响
S C Heinrichs
S C Heinrichs
Corticotropin-releasing factor (CRF) is a pluripotent neurohormone system, which implements endocrine, physiological and behavioral responses to stressor exposure. Built-in biological diversity and selectivity of CRF system function is prov...
P J Elliot,J Adams
P J Elliot
The proteasome is present in all cells, from yeast to man, where it is central to the proteolytic degradation of the vast majority of intracellular proteins. As such, many groups have examined the role of the proteasome with respect to thei...
C L Strickland,P C Weber
C L Strickland
Emerging therapies for the treatment of cancer rely on detailed knowledge of cell growth mechanisms. It is hoped that mechanism-based inhibitors will prove more effective and exhibit fewer side effects than current treatments. Among the fir...
Therapeutic applications and design of mast cell tryptase inhibitors [0.03%]
肥大细胞 tryptase 抑制剂的治疗应用和设计
K D Rice,P A Sprengeler
K D Rice
In recent years, a role for the mast cell has emerged as a multifunctional, key effector cell in the immune system and may also serve to modulate the inflammatory response and immune-nervous system interactions. Mast cell stimulation leads ...
N Borkakoti
N Borkakoti
Over the last decade, the potential utility of matrix metalloproteinase (MMP) inhibitors as novel therapeutic agents for diseases such as arthritis, cancer and multiple sclerosis has lead to an abundance of three-dimensional structural info...
Recent advances in our understanding of peptide hormone receptors and RAMPS [0.03%]
近年人们对肽类激素受体和RAMPS的了解取得了新进展
P M Sexton
P M Sexton
The family B or class II group of G-protein coupled receptors encompasses receptors for peptide hormones including secretin, vasoactive intestinal polypeptide, glucagon, parathyroid hormone and calcitonin. Receptor activity modifying protei...
N Beeley,C H Hill
N Beeley