Children With Celiac Disease Have a Higher Degree of Activated or Exhausted CD4+ and CD8+ T Cells Compared to Healthy References [0.03%]
儿童乳糜泻患者的CD4+和CD8+T细胞活化或衰竭程度高于健康参考人群
Andrea Tompa,Junko Johansson,Maria Faresjö
Andrea Tompa
Type 1 diabetes (T1D) and celiac disease (CeD) are two chronic autoimmune disorders commonly diagnosed during childhood. In this exploratory study we performed flow cytometric immunophenotyping of various immune cell populations in peripher...
Investigation of the Effect of Hormonal Therapy on Lupus Pathology and Reproductive System Damages in a Pristane-Induced Mouse Model of Systemic Lupus Erythematosus [0.03%]
激素治疗对系统性红斑狼疮(pristane诱导的小鼠模型)病理及生殖系统损伤的影响研究
Gabriela Boneva,Ekaterina Kurteva,Nikola Ralchev et al.
Gabriela Boneva et al.
Systemic lupus erythematosus (SLE) is an example of an autoimmune disease manifesting itself in an aberrated immune response directed against nuclear, cytoplasmic and cell-surface antigens. Among patients, symptoms are frequently intensifie...
Sex Dependent and Sjögren Disease Like Immune Responses Against Phosphoantigens in Balb/C Mice [0.03%]
雌雄小鼠对磷脂抗原免疫应答的性别差异及干燥综合症样免疫反应
Paulina Czwakiel,Björn Brindefalk,Atiyeh Eghbali et al.
Paulina Czwakiel et al.
The initial aim of this study on Balb/C mice was to investigate the putative effects on feeding and appetite of isopentenyl pyrophosphate (IPP) and E-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), also known as phosphoantigens (pAgs)....
Treat-To-Target: Emergence of Second-Generation CD40L Inhibitors for Treatment of SLE-Identifying Beneficial Patient Candidates for CD40L Inhibitors in a Cross-Sectional SLE Cohort [0.03%]
治疗目标：二代CD40L抑制剂治疗SLE的出现——在横断面SLE队列中确定二代CD40L抑制剂的潜在受益人群
Kathrine Pedersen,Annette Gudmann Hansen,Yaseelan Palarasah et al.
Kathrine Pedersen et al.
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterised by heterogeneous clinical manifestations and varying degrees of organ involvement. The CD40-CD40 Ligand (CD40L) pathway is implicated in autoimmune responses, ...
Synovial Fluid Proteomic Signatures in Different Subtypes of Juvenile Idiopathic Arthritis [0.03%]
不同类型的幼年特发性关节炎的滑膜液蛋白质组特征分析
Narendra Kumar Bagri,Saumya Srivastava,Yogendra Singh et al.
Narendra Kumar Bagri et al.
Juvenile idiopathic arthritis (JIA) encompasses distinct inflammatory subtypes such as polyarticular (pJIA), oligoarticular (oJIA), systemic onset (sJIA) and enthesitis-related arthritis (ERA). The molecular mechanisms underlying these subt...
AIM2 Dampens the Homeostasis of Murine Inhibitory CD8+Ly49+ Regulatory T Cells [0.03%]
AIM2抑制小鼠抑制性CD8+Ly49+调节性T细胞的稳态
Ping Yi,Jiao Jiang,Ming Yang et al.
Ping Yi et al.
Associations Between Pre-Transplantation T Cell Populations and Acute Cellular Rejection Post-Liver Transplantation-Results From a Prospective Cohort Study [0.03%]
肝移植前T细胞亚群与术后急性细胞排斥反应的关联:一项前瞻性队列研究的结果分析
Julius Leander Ross Clemmesen,Moises Alberto Suarez-Zdunek,Dina Leth Møller et al.
Julius Leander Ross Clemmesen et al.
Acute cellular rejection (ACR) remains a common complication post-liver transplantation despite standardised immunosuppressive regimens. Identifying patients at high risk of ACR is challenging, and new tools for prediction are needed. This ...
Essential Role of NLRC5 in Cancer Immune Surveillance and Cancer Immunoediting [0.03%]
NLRC5在癌症免疫监视和免疫编辑中的重要作用
Akhil Shukla,Anny Armas Cayarga,Jean-François Lucier et al.
Akhil Shukla et al.
A key mechanism of tumour immune escape from CD8+ cytotoxic T lymphocytes occurs via downregulation of NLRC5, an IFNγ-induced transcriptional activator of MHC class-I. As NLRC5 deficiency does not abrogate CD8+ T cell development, we inves...
Nga Shan Li,Yu-Wen Yeh,Liuying Li et al.
Nga Shan Li et al.
Mast cells have long been recognised for their pivotal role in the development of allergic inflammation. However, their contributions extend far beyond this well-established function. Accumulating evidence supports that mast cells play esse...
Multiparametric Optimization of Human Primary B-Cell Cultures Using Design of Experiments [0.03%]
基于实验设计的人原代B细胞培养的多参数优化
Anne Bruun Rovsing,Kenneth Green,Lisbeth Jensen et al.
Anne Bruun Rovsing et al.
B cells are essential in the immune system, driving antibody production, cytokine secretion and antigen presentation. Studies in mouse models have illuminated key mechanisms underlying B-cell activation, differentiation, class-switch recomb...