Essential Role of NLRC5 in Cancer Immune Surveillance and Cancer Immunoediting
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A key mechanism of tumour immune escape from CD8+ cytotoxic T lymphocytes occurs via downregulation of NLRC5, an IFNγ-induced transcriptional activator of MHC class-I. As NLRC5 deficiency does not abrogate CD8+ T cell development, we investigated whether NLRC... ...
