Novel Biomarker for Rheumatoid Arthritis: Serum Peptidylarginine Deiminase 4-Potentiating Activity in an Anti-Citrullinated Protein Antibody-Positive At-Risk Population [0.03%]
新的类风湿关节炎生物标志物：抗瓜氨酸蛋白抗体阳性高危人群血清瓜氨酸肽酶活性升高
Marta Kaminska,Vijay Joshua,Ewa Bielecka et al.
Marta Kaminska et al.
Enzymes like peptidylarginine deiminase 4 (PAD4) generate citrullinated epitopes that are crucial in triggering and driving the anti-citrullinated protein antibody (ACPA) response in rheumatoid arthritis. Here, we assessed whether serum PAD...
Molecular Mechanisms of NETs and Platelet Interactions and Their Regulatory Functions in Sepsis [0.03%]
NETs与血小板相互作用的分子机制及其在脓毒症中的调控功能
Zhongji Han,Jing Xu,Maokui Yue
Zhongji Han
In recent years, neutrophil extracellular traps (NETs) have attracted widespread attention due to their roles in immune response and inflammation. Platelets have been shown to play a dual role as both stimulators and responders in the forma...
Abnormal Expression of Suppressor of Cytokine Signalling (SOCS) Molecules Contributes to the Development of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis [0.03%]
细胞因子信号传导抑制分子异常表达参与多发性硬化和实验性自身免疫性脑脊髓炎的发病机制
Abdollah Jafarzadeh,Narges Mikaeili,Zahra Jafarzadeh
Abdollah Jafarzadeh
To regulate immune and inflammatory responses, suppressor of cytokine signalling (SOCS) proteins bind to multiple signalling components downstream of cytokine receptors, such as Janus kinase (JAK) and signal transducers and activators of tr...
Clinical Manifestations and Immunologic Phenotype in Patients With RAG1/2 Mutations: A Single Centre Experience and Description of A Novel Mutation [0.03%]
RAG1/2突变患者的临床表现和免疫表型特征：单一中心经验及一种新突变的报道
Işılay Turan,Selami Ulaş,Sezin Naiboğlu et al.
Işılay Turan et al.
Recombination-activating genes (RAG1 and RAG2) encode lymphoid-specific proteins that are essential for V(D)J recombination during early T- and B-lymphocyte development. Biallelic mutations in these genes result in a broad spectrum of prima...
UNC13D in Familial Hemophagocytic Lymphohistiocytosis and Beyond: Functional Mechanisms, Genetic Variants, Multisystem Disease Spectrum and Clinical Implications [0.03%]
家族性噬血细胞淋巴组织细胞增多症及其他疾病的UNC13D功能机制、遗传变异、多系统疾病谱系及临床意义
Ziqian Wang,Chong Chen,Zhaojun Duan et al.
Ziqian Wang et al.
The UNC13D gene encodes Munc13-4, a key regulator of cytotoxic granule exocytosis in effector immune cells, enabling the release of perforin and granzymes that are essential for cytotoxic function and immune surveillance. Loss-of-function m...
Murine Intestinal Neonatal and Adult Dendritic Cell Subset Migration and Activation Characteristics in Response to Toll-Like Receptor Stimulation Through MyD88 [0.03%]
髓系造血干细胞向肠内迁移及其在TLR刺激下活化特征的MyD88依赖性研究
Konjit Getachew Muleta,Signe Holst,Agnès Garcias López et al.
Konjit Getachew Muleta et al.
The initiation of adaptive immunity requires antigen presentation in immune inductive sites. Classical dendritic cells (cDC) sense peripheral immune response inducing cues and migrate to the tissue-draining lymph nodes upon engagement, wher...
Decoding NK Cell Subset Dysregulation in SARS-CoV-2 Infection: Phenotypic, Functional, and Transcriptomic Insights Into COVID-19 Pathogenesis [0.03%]
SARS-CoV-2感染中NK细胞亚群失调的解码：COVID-19发病机制的表型、功能和转录组学见解
Marlyn D Sepúlveda,Walter D Cardona Maya,Wildeman Zapata-Builes et al.
Marlyn D Sepúlveda et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly affects innate immune responses, particularly those of natural killer (NK) cells, which play an important role in antiviral defence. This review combines p...
Itaconate as a Potent Regulator of Neutrophil Responses in Host Defence and Inflammation [0.03%]
柠檬酸盐在宿主防御和炎症中的强力调节作用及其对中性粒细胞反应的影响
Chunying Cheng,Zufeng Cheng,Xinran Ye et al.
Chunying Cheng et al.
Itaconate, derived from cis-aconitate decarboxylation by immune-responsive gene 1 (IRG1; also called cis-aconitate decarboxylase 1, ACOD1), is an intermediate metabolite of the tricarboxylic acid (TCA) cycle in the mitochondria. The product...
Gabrielle Gimenes Lima,Ana Flávia Segati,Giovanna Santos Oliveira et al.
Gabrielle Gimenes Lima et al.
Pregnant individuals were prioritised for COVID-19 research due to concerns about increased susceptibility and limited clinical trial data. This narrative review synthesises evidence on maternal infection, immunological adaptations, placent...