Nuclear Factor Kappa B (NF-κB)1 and NF-κB2 Deficiency: An Unpredictable Defect With Wide Clinical and Immunologic Phenotype [0.03%]
核因子κB（NF-κB）1和NF-κB2缺陷：具有广泛临床和免疫表型的不可预测缺陷
Selin Sevinç,Candan İslamoğlu,Şule Haskoloğlu et al.
Selin Sevinç et al.
The Nuclear Factor Kappa B (NF-kB) signalling pathway is essential for regulating inflammation, cell survival, and adaptive immune responses through its canonical (NF-κB1-associated) and noncanonical (NF-κB2-associated) branches. The cano...
Evolution and Mechanistic Insights of Immunometabolism in Metabolic Diseases and Infections [0.03%]
免疫代谢在代谢性疾病和感染中的发展和机制见解
Wenbin Tan
Wenbin Tan
Immunometabolism, an emerging field exploring metabolic reprogramming and functional regulation in immune cells, offers a lens for understanding complex diseases. This review delineates core concepts, key signalling nodes-emphasising the me...
Impact of CD38 Deficiency on B Cell Development in CD19-Deficient Mice [0.03%]
CD19缺陷小鼠中CD38缺乏对B细胞发育的影响
A Abrego-Peredo,C A Gallardo-Hernández,G López-Herrera et al.
A Abrego-Peredo et al.
Physical interaction between the CD38 and CD19 proteins has been previously described. However, this association through the development of B lymphocytes has yet to be thoroughly investigated. To address this, we generated mice with a simul...
Decreased PD-1+ NK and T Cell Populations in Peritoneal Fluid contribute to Immune Dysregulation in Endometriosis [0.03%]
PD-1+NK和T细胞在盆腔积液中减少导致子宫内膜异位症免疫功能失调
Anna Tresso,Niharika Thota,Chloe James et al.
Anna Tresso et al.
Endometriosis is associated with chronic pelvic pain, largely due to immune dysregulation within the peritoneal cavity. The activation status of peritoneal immune cells is not well understood, and comparisons with systemic immune cells may ...
Impact of Bacterial Membrane Vesicles on Cellular Responses in Leishmania amazonensis-Infected Macrophages In Vitro [0.03%]
细菌膜囊泡对利什曼原虫感染的巨噬细胞中细胞反应的影响
Pedro Henrique Gallo-Francisco,Genesy Pérez Jorge,Guilherme Augusto Sanches Roque et al.
Pedro Henrique Gallo-Francisco et al.
Leishmania amazonensis is an intracellular protozoan parasite and etiological agent of Localised Cutaneous Leishmaniasis (LCL). A challenge in managing LCL is the frequent occurrence of secondary bacterial co-infections caused by opportunis...
Dupilumab in Severe Atopic Dermatitis With Phosphoglucomutase 3 Deficiency [0.03%]
磷葡萄糖变位酶3缺乏重症特应性皮炎患者使用杜普利尤单抗治疗效果良好
Muhammed Aydin,Zeynep Meric,Dilan Demir Gumus et al.
Muhammed Aydin et al.
Therapeutic Potential of Group 2 Innate Lymphoid Cells in Neuroinflammatory Diseases [0.03%]
2型固有淋巴细胞在神经炎症性疾病治疗中的潜力
Qinhui Ye,Qun Yu,An Ping
Qinhui Ye
Group 2 innate lymphoid cells (ILC2s) are tissue-resident immune cells that regulate type 2 immunity, neuroimmune communication, inflammation resolution and tissue repair. Although ILC2s are best characterized in peripheral barrier tissues,...
Recent Thymic Emigrant Levels in Inborn Errors of Immunity: Is Their Diagnostic Value Greater Than We Think? [0.03%]
遗传性免疫缺陷患者近期胸腺移出细胞水平的研究：它们的诊断价值是否大于我们的认知？
Selami Ulaş,Serdar Al,Sezin Naiboğlu et al.
Selami Ulaş et al.
We aimed to evaluate the sensitivity and specificity of Recent Thymic Emigrant (RTE) levels for diagnostic discrimination among various Inborn Errors of Immunity (IEI) subgroups. We analysed 205 paediatric patients diagnosed with IEI at the...
The EBNA-1 Conundrum: Does Epstein-Barr Virus Invoke Autoimmune Pathology in a Population Subset by Poorly Purine-Loading Its Major Latency-Maintaining Transcript? [0.03%]
EB病毒_invoke_自身免疫病理的子集人群:_通过较差的嘌呤负荷其主要潜伏维持转录本导致的EBNA-1难题?
Donald R Forsdyke
Donald R Forsdyke
Viruses activate host defences by alerting interferon and other alarms. Viruses seeking latency must curtail this. Infected subjects would then have minimal immune system activation and remain healthy. However, a minority cannot prevent eme...
Unsupervised Flow Cytometry Reveals a Constant Shift Towards Activated CD4+ T Cell Subsets in APECED [0.03%]
无监督流式细胞术揭示APECED中激活的CD4+T细胞亚群呈恒定变化趋势
Joonatan Mattila,Nelli Heikkilä,Iivo Hetemäki et al.
Joonatan Mattila et al.
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare monogenic autoimmune disease caused by loss-of-function mutations in the Autoimmune regulator gene and the subsequent impairment of negative selection in the ...