From Neoantigen Discovery to Immune-Checkpoint Synergy: Peptide Cancer Vaccines as Precision Tools for Personalised Cancer Therapy [0.03%]
从新抗原发现到免疫检查点协同作用：肽癌症疫苗作为精准的个性化癌症治疗工具
Abid H Banday,Meer Mehru Manzoor,Urooj Nissar et al.
Abid H Banday et al.
The diagnosis, management and potential eradication of cancer depend on tumour type, stage, extent and anatomical location. While surgery, chemotherapy and radiotherapy remain central, advances in molecular oncology have shifted treatment t...
Patients Suffering From Post-COVID-19 Syndrome Feature Enhanced Antibody Reactivity Towards Specific Linear Epitopes Within EBV EBNA1 [0.03%]
罹患新冠后遗症的患者体内针对EB病毒EBNA1特定线性表位的抗体反应性增强
Peter Lorenz,Felix Steinbeck,Florian Fricke et al.
Peter Lorenz et al.
Post-COVID-19 syndrome (PCS; also known as post-acute sequelae of COVID-19, PASC and Long COVID) manifests with various clinical symptoms of unclear aetiology that persist or develop months after acute infection with SARS-CoV-2. Potential t...
The New Insight Into the Role of Transcription Factors in the Function of Regulatory T Cells With Emphasis on FOXP3 and Its Implication in the Treatment of Autoimmune Disorders [0.03%]
转录因子在调节性T细胞功能中的新见解及其对自身免疫病治疗的意义——以FOXP3研究为重点
Afsaneh Shamsi,Mahdi Taghadosi,Fatemeh Khoobbakht
Afsaneh Shamsi
Peripheral immune tolerance is a cardinal feature of the adaptive immune system, which makes self-nonself discrimination and unresponsiveness toward self-antigens. Disruption in the regulation of these processes leads to damage to self-tiss...
LTB4 Activates the MAP Kinase Pathway in Endothelial Cells to Cause Long-Lasting Neutrophil Tethering, MCP-1 and NO Releases [0.03%]
LTB4通过活化内皮细胞的MAP激酶途径发挥持久的中性粒细胞滚翻、促进MCP-1和NO释放的作用
Anne-Sofie Johansson,Jesper Z Haeggström,Jan Palmblad
Anne-Sofie Johansson
Leukotriene B4 (LTB4), a potent chemotactic and immune-modulating eicosanoid, signals via two receptors (BLT1 and BLT2), leading to rapid but transient migratory, adhesive and secretory responses in phagocytes. Previously, we reported that ...
Non-Neutralising Antibodies and T Cell Responses to SARS-CoV-2 Detected in Unvaccinated SARS-CoV-2-Naive Spanish Adolescents [0.03%]
在未接触过SARS-CoV-2的西班牙青少年中检测到非中和抗体和T细胞反应
Hector F Pelaez-Prestel,Tara Fiyouzi,Sara Alonso Fernandez et al.
Hector F Pelaez-Prestel et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents usually follows a mild or asymptomatic course. In this brief report, we investigated the cellular and humoral responses to SARS-CoV-2 in six ...
C-Reactive Protein Mediates the Association Between Rheumatoid Arthritis and Immune Thrombocytopenia: An Observational and Mendelian Randomisation Study [0.03%]
C-反应蛋白介导了类风湿关节炎与免疫性血小板减少症的关联：一项观察及孟德尔随机化研究
Wuxia Yang,Zhen Wang,Yanqi Song et al.
Wuxia Yang et al.
Thrombocytopenia has been increasingly observed in patients with rheumatoid arthritis (RA) in clinical practice. However, whether this association reflects a causal relationship remains unclear. This study aims to investigate the causal eff...
Observational Study
Scandinavian journal of immunology. 2025 Dec;102(6):e70081. DOI:10.1111/sji.70081 2025
Untargeted Metabolomic Profiling Reveals Lipid Metabolism Dysregulation in Patients With Immune Thrombocytopenia [0.03%]
未靶向代谢组学揭示免疫性血小板减少症患者脂质代谢紊乱
Xin Zhou,Yuqi Shi,Mengran Li et al.
Xin Zhou et al.
Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterised by immune-mediated platelet destruction, yet its metabolic underpinnings remain incompletely understood. In this study, we applied a non-targeted serum metabolom...
From Spike to Strike: SARS-CoV-2 mRNA Vaccines Sensitise Tumours to PD-1/PD-L1 Blockade [0.03%]
从刺突到打击——SARS-CoV-2 mRNA疫苗使肿瘤对PD-1/PD-L1阻断敏感化
Julian Jamie Freen-van Heeren
Julian Jamie Freen-van Heeren
This letter comments on work by Grippin et al. demonstrating that SARS-CoV-2 mRNA vaccines can reprogram the tumour microenvironment and enhance PD-1/PD-L1 blockade, suggesting broader implications for mRNA-driven immune activation in cance...
Nonlinear Modelling Reveals a Refined Relationship Between Polymorphonuclear Leukocytes and Postsurgical Inflammatory and Organ Damage Responses [0.03%]
非线性模型揭示了中性粒细胞与术后炎症和器官损伤反应之间的关系
Jordan A Phillips,Jonghoon Kang
Jordan A Phillips
Transforming Vitiligo Diagnosis and Treatment Through Artificial Intelligence: A Review [0.03%]
人工智能在白癜风诊疗中的应用进展及挑战
Nasser Gholijani,Zahra Taheri,Maryam Bazgiri et al.
Nasser Gholijani et al.
Vitiligo is a complex autoimmune disease of the skin characterised by the loss of melanocytes, resulting in depigmented patches on the skin. Despite advances in clinical diagnosis and treatment, challenges such as delayed diagnosis and limi...