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LTB4 Activates the MAP Kinase Pathway in Endothelial Cells to Cause Long-Lasting Neutrophil Tethering, MCP-1 and NO Releases

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Leukotriene B4 (LTB4), a potent chemotactic and immune-modulating eicosanoid, signals via two receptors (BLT1 and BLT2), leading to rapid but transient migratory, adhesive and secretory responses in phagocytes. Previously, we reported that BLT1 is the predomin... ...