Pharmacokinetics, Amino Acid Responses, and Short-Term Tolerability of Intravenous and Oral L-Citrulline in Healthy Neonatal Holstein Calves [0.03%]
静脉和口服L-瓜氨酸在健康牛犊体内的药代动力学、氨基酸反应及短期耐受性研究
Mehmet Gültekin,Murat Boyacıoğlu,Hasan Erdoğan et al.
Mehmet Gültekin et al.
L-citrulline is a precursor for endogenous arginine synthesis, supporting nitric oxide production and urea cycle function, yet its pharmacokinetics in neonatal calves are unknown. This study characterized and compared the pharmacokinetics o...
Trimethoprim Urine Excretion and Its Potential for Treating Canine Urinary Tract Infections [0.03%]
磺胺甲恶唑的尿液排泄及其治疗犬泌尿道感染的潜力
Butch KuKanich,Kate KuKanich,Brooke Paisley
Butch KuKanich
Antimicrobial resistant urinary tract infections (UTI) in dogs are becoming more common, and treatment options can be limited. Sulfonamide antimicrobials, often in combination with trimethoprim, can be used. However, sulfonamides may produc...
Pharmacokinetics of Intravenous and Intramuscular Nalbuphine in Isoflurane-Anesthetized Chickens (Gallus gallus domesticus) [0.03%]
异氟醚麻醉下注射纳布啡在鸡（Gallus gallus domesticus）体内的药动学研究
Eduardo Almeida Ruivo Dos Santos,Eduardo Raposo Monteiro,Laura Ben Olivo et al.
Eduardo Almeida Ruivo Dos Santos et al.
This study aimed to determine the pharmacokinetics of nalbuphine following intravenous (IV) or intramuscular (IM) administration in six adult H&N Brown chickens anesthetized with isoflurane. In a randomized crossover study, nalbuphine (12.5...
Residue Kinetics and Dietary Risk Assessment of Diazepam and Its Metabolites in Grass Carp (Ctenopharyngodon idella): Implications for Aquaculture Safety [0.03%]
地西泮及其代谢物在草鱼中的残留动态及膳食风险评估：养殖安全性启示
Qi Shan,Feng Xu,Mingyuan Wu et al.
Qi Shan et al.
Diazepam (DZP), a benzodiazepine sedative, has been increasingly detected in various aquatic products including fish, shrimp, and crab in recent surveillance studies, raising public health concerns. This study systematically investigates th...
Jenni Lindstedt,Jouko M Levijoki,Johanna Tuunainen et al.
Jenni Lindstedt et al.
This exploratory randomized crossover study investigated pharmacokinetic interactions, functional alertness, and cardiovascular safety of tasipimidine oral solution administered alone and in combination with fluoxetine in healthy Beagle dog...
The Impact of Ketoprofen on the Pharmacokinetics of Marbofloxacin at Variable Intravenous Doses in Sheep [0.03%]
不同剂量静脉注射时卡托普利对绵羊体内马波罗星药动学的影响
Muhittin Uslu,Rahmi Canbar,Orhan Corum et al.
Muhittin Uslu et al.
The objective of this study was to determine the effect of ketoprofen (3 mg/kg, IV) on the pharmacokinetics of marbofloxacin administered intravenously at 2 and 10 mg/kg in sheep, and to identify possible changes in key pharmacokinetic para...
Different Roles of Canine Cytochrome P450 2C and 3A Enzymes Involved in the Oxidative Metabolism of Phenobarbital, a Key Anticonvulsant for Dogs: Comparison With Human P450 Enzymes [0.03%]
参与犬抗惊厥药苯巴比妥氧化代谢的细胞色素P450 2C和3A不同作用及与人类P450酶的比较
Yasuhiro Uno,Koya Fukunaga,Norie Murayama et al.
Yasuhiro Uno et al.
Phenobarbital is a key anticonvulsant used in dogs. Cytochrome P450 (P450) 2C19 is reportedly involved in the oxidative metabolism of phenobarbital in humans; however, the hepatic P450 enzymes responsible for phenobarbital p-hydroxylation i...
What Do We Know About Cyclooxygenases Expression in the Lower Urinary Tract of Dogs and Cats? A Systematic Review [0.03%]
犬和猫下尿路环氧化酶表达的研究进展——系统性综述
Reiner Silveira de Moraes,Luíz Guilherme Dércore Benevenuto,Ana Giulia Gabriel da Rocha Cesario et al.
Reiner Silveira de Moraes et al.
Cyclooxygenases (COX-1 and COX-2) are key enzymes in the biosynthesis of prostanoids, which mediate physiological functions, inflammation, and the process of carcinogenesis. In dogs and cats, lower urinary tract diseases are prevalent and o...
Kevin Pflaum,Julia Albright,Sherry Cox et al.
Kevin Pflaum et al.
Clonidine is an α-2 agonist shown to be both well tolerated and useful in the treatment of canine fear-based disorders, although it is perceived to have a short duration of action. Clonidine is available in regular release and extended-rel...
Veterinary Pharmaceutical Safety Competencies for New Graduates: Description of an Interprofessional Simulated Learning Activity [0.03%]
毕业兽医从业人员的医药安全能力：一种专业模拟学习活动的描述
Margene Anderson,Carrie Schroeder,Kristopher M Schroeder
Margene Anderson
The misuse and abuse of veterinary anesthetic and analgesic agents pose significant public health risks, particularly with the growing presence of ultrapotent opioids and other anesthetics in the illicit drug trade. In response, there is in...