Comparison of Human and Canine P-Glycoprotein Substrates at R, P, and H Binding Sites [0.03%]
人和犬P-糖蛋白R、P和H结合位点底物的比较分析
Neal S Burke,Katrina L Mealey
Neal S Burke
P-glycoprotein (P-gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P-gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P-gp status of dr...
Optimizing the Dosage of Ceftiofur to Treat Porcine Respiratory Infection Based on a Population Pharmacokinetic Model and Monte Carlo Simulation [0.03%]
基于人群药代动力学模型和蒙特卡罗模拟的治疗猪呼吸道感染的头孢噻呋剂量优化研究
Chengyang Zhang,Haiyan Liu,Ziyan Kou et al.
Chengyang Zhang et al.
Porcine respiratory diseases is a major cause of economic losses in livestock, and ceftiofur is one of the core therapeutic agents for its treatment, but the clinical efficacy can be inconsistent. Therefore, it is necessary to utilize a pop...
Time Kill Curve PD Modelling Experiments Are Affected by Trailing MIC Endpoints: Refinement of MIC Determination for S. pseudintermedius [0.03%]
时间杀灭曲线PD模型实验受到MIC终点测定滞后效应的影响：S. pseudintermedius菌种MIC测定的优化方法研究
Andrew Mead,Ludovic Pelligand
Andrew Mead
Trailing endpoints are a recognised challenge in broth microdilution MIC testing, particularly for bacteriostatic agents such as trimethoprim (TMP) and sulphonamides. In this study, we applied a pharmacodynamically guided refinement to dete...
A Pharmacokinetic-Pharmacodynamic Approach to Propose an Amoxicillin Dosage Regimen for Treatment of Escherichia coli and Staphylococcus delphini Infections in Mink (Neovison vison) [0.03%]
基于药动学/药效学的阿莫西林给药方案用于治疗水貂（Neovison vison）感染的构建与评价：以大肠杆菌和 dolphin球菌为研究对象
Amir Atabak Ronaghinia,Nanett Kvist Nikolaisen,Mette Fertner et al.
Amir Atabak Ronaghinia et al.
The aim of this study was to develop amoxicillin (AMX) dosage regimens for the treatment of Escherichia coli and Staphylococcus delphini infections in mink using a pharmacokinetic (PK) and pharmacodynamic (PD) approach. Two animal experimen...
Pharmacokinetics of Ceftazidime After a Single Intramuscular Dose in Whitespotted Bamboo Sharks (Chiloscyllium plagiosum) [0.03%]
单剂量头孢他啶肌肉注射后小白斑竹鲨的药动学研究
Miceala Shocklee,Jennifer Russell,Kelsey Herrick et al.
Miceala Shocklee et al.
Whitespotted bamboo sharks (Chiloscyllium plagiosum) are a common species of elasmobranchs housed in zoos and aquaria. Medical concerns like conspecific trauma and bacterial infections commonly lead to the empirical use of antibiotic medica...
Plasma and Urine Pharmacokinetics of Intravenous Pridinol in Thoroughbreds for Its Medication Control [0.03%]
用于赛马用药监管的注射匹啶醇的血浆和尿液药动学研究
Yohei Minamijima,Taisuke Kuroda,Atsushi Okano et al.
Yohei Minamijima et al.
We examined the pharmacokinetics of intravenous pridinol in six thoroughbred horses. Each horse received a single 20 mg dose of pridinol mesylate via the jugular vein, and plasma and urine samples were collected over 72 h. Liquid chromatogr...
Pharmacokinetics of Remimazolam Versus Midazolam After Intravenous Administration to Horses [0.03%]
马匹静脉注射瑞玛唑仑与咪达唑仑后的药代动力学研究
Masafumi Kawashima,Taisuke Kuroda,Yohei Minamijima et al.
Masafumi Kawashima et al.
Remimazolam (RMZ) is a new short-half-life benzodiazepine used in humans. We compared the pharmacokinetics and sedative effects of RMZ with those of midazolam (MDZ) in Thoroughbred horses. Six Thoroughbreds received a single IV dose of RMZ ...
The Need for a Revision of Fluoroquinolone Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Feline Bacterial Isolates [0.03%]
修订氟喹诺酮类抗生素断点以解释猫源细菌分离株抗菌药物敏感性试验结果的必要性
Mark G Papich,Lacie A Gunnett,Marilyn N Martinez
Mark G Papich
The fluoroquinolone antimicrobial agents, enrofloxacin and marbofloxacin, were approved in the United States for cats in 1990 and 2001, respectively. In 2023, revised breakpoints for testing isolates from dogs were published. These canine b...
Differences in Plasma Exposure of Cannabidiol and Cannabidiolic Acid Following Oral Administration to Horses [0.03%]
口服给药后大麻二酚和大麻二酚酸马 plasma 暴露差异
Carl Ekstrand,Peter Michanek,Elin Hernlund et al.
Carl Ekstrand et al.
There has been a growing interest in the use of cannabinoids in horses in recent years. Several studies have reported on the pharmacokinetics of cannabidiol (CBD) in horses. However, cannabidiolic acid (CBDA) has received less attention, de...
Pharmacokinetics and Withdrawal Period of Oxolinic Acid in Silver Pompano Following In-Feed Administration of the Recommended Therapeutic Dose [0.03%]
推荐治疗剂量磺醚甲胩混饲投喂金线鱼的药动学及休药期研究
Sumithra Thangalazhy Gopakumar,Krupesha Sharma Sulumane Ramachandra,Ambarish Purackattu Gop et al.
Sumithra Thangalazhy Gopakumar et al.
Oxolinic acid (OA) is a widely recommended antimicrobial agent for managing Gram-negative bacterial infections in aquaculture. This study investigates the pharmacokinetics and withdrawal period of OA in Trachinotus blochii, a high-value mar...