Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses [0.03%]
血浆中盐酸坦度螺酮的药动学及生理效应研究
Annabella D Lynch,Khursheed R Mama,Dan S McKemie et al.
Annabella D Lynch et al.
Tapentadol is a dual mechanism analgesic utilizing both μ-opioid receptor (MOR) agonism and norepinephrine reuptake inhibition (NRI). This study evaluated the pharmacokinetics and pharmacodynamics of tapentadol as a potential analgesic wit...
A Visual Analogue Scale Exercise for Teaching Antimicrobial Selection in Veterinary Pharmacology: Tool Development and Initial Implementation [0.03%]
一种用于兽医药理学抗微生物选择教学的视觉模拟量表练习：工具开发与初步实施
Carly A Patterson,Jordan Tayce,Johanna C Heseltine
Carly A Patterson
Veterinary students often find it difficult to select antimicrobial drugs for patients, likely because it requires them to consider multiple factors and there are frequently several possible options with a lack of a defined "correct or inco...
Comparative Pharmacokinetics of Gentamicin in Healthy Young-Adult and Geriatric Horses [0.03%]
青壮年马和老年马体内庆大霉素的药动学比较研究
Michelle L Ceresia,Daniela Bedenice,Andrew Gestrich et al.
Michelle L Ceresia et al.
Aging may modify the pharmacokinetic disposition and excretion of gentamicin, although drug dose adjustments in aged horses are uncommon in clinical practice. Since high-dose, once daily dosing of gentamicin is considered therapeutically mo...
Pharmacokinetics of a Single Subcutaneous Extended-Release Buprenorphine (Ethiqa XR) in Healthy Beagles [0.03%]
单剂量皮下注射缓释丁丙诺啡（Ethiqa XR）在健康比格犬体内的药代动力学研究
Kornelia Tiffinger,Hiroko Enomoto,Ronald E Baynes et al.
Kornelia Tiffinger et al.
This study evaluated the pharmacokinetics of an extended-release buprenorphine formulation (Ethiqa XR) in dogs and explored potential sex differences. Twelve healthy intact beagles (6 males and 6 females) received a single subcutaneous inje...
Pharmacokinetics of Diclazuril in the Plasma and Cerebrospinal Fluid of Healthy Adult Horses After a Single Oral Dose Administered as a Pelleted Topdressing [0.03%]
单次口服给药后健康成年马匹血浆和脑脊液中敌菌净的药代动力学研究
Elizabeth J Treece,Kate L Hepworth-Warren,Mark G Papich et al.
Elizabeth J Treece et al.
Equine protozoal myeloencephalitis can cause acute infections with rapid onset of neurologic signs, necessitating immediate empiric therapy with antiprotozoal medication. The objective of the study was to identify when concentrations of dic...
Plasma Pharmacokinetic Profile of Fipronil 1% Pour-On in Cattle: Photodegradation and the Sustained Systemic Persistence of Fipronil Sulfone [0.03%]
1％西维因浇背剂在牛体内的药动学特征：光降解与右苯基硫
Stefani Maria Ferreira,Leonila Ester Reinert Raspantini,Giselle Kindlein et al.
Stefani Maria Ferreira et al.
This study characterized the long-term pharmacokinetic profile of a 1% fipronil pour-on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil a...
How We Teach and Assess Competencies in Evidence-Based Veterinary Medicine in Preclinical Veterinary Coursework by Integrating the Expertise of a Veterinary Pharmacologist and Information Specialists/Librarians [0.03%]
药理学家和信息专业人士/馆员整合 expertise在预临床兽医课程中教授和评估基于证据的兽医医学的能力素质的方法
Heather K Moberly,Virginia Fajt,L M Rey
Heather K Moberly
At the Texas A&M University College of Veterinary Medicine (TAMU-CVM), the veterinary pharmacology faculty and library faculty have collaborated to teach aspects of Evidence-Based Veterinary Medicine (EBVM) since 2010. These skills are inte...
Pharmacokinetic Profiles of Enrofloxacin and Its Metabolite Ciprofloxacin Administered by Different Doses in Calves [0.03%]
不同剂量恩诺沙星及其代谢物环丙沙星在犊牛体内的药动学特征
Kamil Uney,Orhan Corum,Murat Yuksel et al.
Kamil Uney et al.
This research studied dose-dependent changes in the pharmacokinetics of enrofloxacin (ENR) and its active metabolite, ciprofloxacin (CIP), in calves. The research was performed on eighteen calves utilizing a parallel pharmacokinetic approac...
Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs [0.03%]
曲马多对犬静脉给药安替匹林代谢物药代动力学的影响
Andressa Nunes Mouta,Kathryn Nóbrega Arcoverde,Robson Dos Anjos Honorato et al.
Andressa Nunes Mouta et al.
This study aimed to compare the pharmacokinetic profile of the active dipyrone metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) administered alone and in combination with tramadol in dogs. Nine mixed-breed dogs, weighing...