Increased CD8dim and Decreased CD8bright T Cells as Immunological Signature for Multibacilary Leprosy Patients [0.03%]
多重分枝杆菌结核病患者CD8dim和CD8brightT细胞减少作为免疫特征
Yuri Scheidegger de Castro,Letícia Silva Nascimento,Juliana Azevedo da Silva et al.
Yuri Scheidegger de Castro et al.
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, manifests in a spectrum of clinical forms and severity. This study investigated the percentage of CD8+ T cells and their subpopulations (CD8bright and CD8dim T cells) in ...
Immunomodulatory Mechanisms of ILC2 in Lung Development: Emerging Insights Into Bronchopulmonary Dysplasia Pathogenesis [0.03%]
肺朗格汉斯细胞在肺发育中的免疫调节机制：支气管肺发育不全发病机理的新见解
Jie Zhu,Jia Tang,Mi Yan et al.
Jie Zhu et al.
Bronchopulmonary dysplasia (BPD) is a severe lung disease affecting preterm infants. The incidence rate in preterm infants aged < 25 weeks is > 70% and it causes irreversible lung damage. BPD is a high-risk factor for respiratory system inf...
Review
Immunology. 2025 May 4. DOI:10.1111/imm.13942 2025
Non-Antigen-Specific B Cells Induced Regulatory CD4+ T Cells Through Decreasing T Cell Activation [0.03%]
非抗原特异性B细胞通过降低T细胞活化诱导调节性CD4⁺T细胞
Chien-Hui Chien,Tsai-Ying Yeh,Bor-Luen Chiang
Chien-Hui Chien
Our previous findings demonstrated that naïve B cells elicit suppressive CD4+ regulatory T (Treg) cells, named as Treg-of-B cells. However, the capability of antigen-specific B cells in that process remains unclear. Using ovalbumin (OVA) a...
Human Alveolar Macrophages Detect SARS-CoV-2 Envelope Protein Through TLR2 and TLR4 and Secrete Cytokines in Response [0.03%]
人肺泡巨噬细胞通过TLR2和TLR4识别SARS-CoV-2包膜蛋白并作出反应分泌细胞因子
Conor Grant,Emily Duffin,Finbarr O&#x;Connell et al.
Conor Grant et al.
Alveolar macrophages (AMs) are the most numerous immune cells of the lung and are the resident, sentinel lung immunocytes that summon trafficking immune cells to the compartment. Immune profiling of AMs from COVID-19 patients implicates AMs...
Intestinal Butyrate Ameliorates Rheumatoid Arthritis Through Promoting the Expression of Cortistatin in Ileum via HDAC3-Vitamin D Receptor Pathway [0.03%]
肠道丁酸通过HDAC3-维生素D受体途径促进回肠环肽的表达来改善类风湿性关节炎
Minghui Liao,Yanrong Zhu,Qi Cui et al.
Minghui Liao et al.
Butyrate, administered orally or via drinking water, can effectively ameliorate experimental rheumatoid arthritis (RA) in mice despite its limited bioavailability. The discrepancy urges us to explore the involvement and role of intestinal a...
Unravelling the Impact of Outer Membrane Protein, OmpA, From S. Typhimurium on Aberrant AID Expression and IgM to IgA Class Switching in Human B-Cells [0.03%]
解构S. Typhimurium外膜蛋白OmpA对人类B细胞异常AID表达及IgM到IgA类别转换的影响
Rahul Chaudhari,Mallar Dasgupta,Prashant Kodgire
Rahul Chaudhari
Salmonella enterica serovar Typhimurium is a Gram-negative bacterium that causes gastrointestinal infection and poses significant public health risks worldwide. This study aims to explore how S. Typhimurium manipulates B-cell function throu...
Development of a Novel Multi-Epitope Vaccine Against Streptococcus anginosus Infection via Reverse Vaccinology Approach [0.03%]
通过反向 vaccinology 方法针对 Streptococcus anginosus 感染开发新型多表位疫苗
Linglan Xu,Nan Xie,Yiqing Liu et al.
Linglan Xu et al.
Streptococcus anginosus is an opportunistic pathogen known for its capability to cause a broad range of infections, posing a significant and growing global health concern. Alongside enhancing diagnostic capabilities and bolstering public he...
Obesity-Induced Metabolic Priming Exacerbates SARS-CoV-2 Inflammation [0.03%]
肥胖引起的代谢启动加剧了SARS-CoV-2引发的炎症反应
Gustavo Gastão Davanzo,Bianca Gazieri Castelucci,Gabriela Fabiano de Souza et al.
Gustavo Gastão Davanzo et al.
Despite the early recognition that individuals living with obesity are more prone to develop adverse outcomes during COVID-19, the mechanisms underlying these conditions are still unclear. During obesity, an accumulation of free fatty acids...
Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition [0.03%]
抑制异戊二烯途径可导致人类γδT细胞功能障碍
Tsz Kin Suen,Burcu Al,Thomas Ulas et al.
Tsz Kin Suen et al.
Vδ2 T cells, a predominant human peripheral γδ T cell population, are a promising candidate for the development of immunotherapies against cancer and infected cells. Aminobisphosphonate drugs, such as zoledronate, are commonly used to ex...
Clinical C3 Inhibition With AMY-101 Reveals Novel Insights Into IL-8-Driven Inflammation in COVID-19 [0.03%]
AMY-101的临床C3抑制为揭示COVID-19中IL-8驱动性炎症提供新见解
Christina Antoniadou,Anastasia-Maria Natsi,Dimitrios C Mastellos et al.
Christina Antoniadou et al.