Abelson tyrosine kinase controls BCR signalling and B-cell differentiation by promoting B-cell metabolism [0.03%]
艾伯森酪氨酸激酶通过促进B细胞代谢来控制BCR信号转导和B细胞分化
Li Luo,Panpan Jiang,Qianglin Chen et al.
Li Luo et al.
As a nonreceptor tyrosine kinase, Abelson tyrosine kinase (c-Abl) was first studied in chronic myelogenous leukaemia, and its role in lymphocytes has been well characterised. c-Abl is involved in B-cell development and CD19-associated B-cel...
The dephosphorylation of FADD at S191 induces an excessive expansion of TCRαβ+ IELs in the intestinal mucosa [0.03%]
FADD去磷酸化诱导小肠黏膜中TCRαβ+ IEL过度扩增
Xuerui Zhang,Banghui Zhu,Lin Li et al.
Xuerui Zhang et al.
Intestinal intraepithelial lymphocytes (IELs) play a crucial role in host defence against pathogens in the intestinal mucosa. The development of intestinal IELs is distinct from peripheral T lymphocytes and remains elusive. Fas-associated p...
Asymmetric T cell division of GAD65 specific naive T cells contribute to an early divergence in the differentiation fate into memory T cell subsets [0.03%]
GAD65特异性初始T细胞的不对称分裂促进效应T细胞向记忆T细胞分化的早期命运决定
Greta Alampi,Debora Vignali,Ilenia Centorame et al.
Greta Alampi et al.
Autoreactive T cells with the phenotype and function of different memory subsets are present in patients who developed type 1 diabetes (TID). According to the progressive differentiation model, memory subsets generate from naïve precursors...
Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model [0.03%]
热灭活结核杆菌、α-Gal 以及斑马鱼：从两种有前景的训练免疫诱导剂与一种经过验证的动物模型的研究经历中获得的新见解
Ramón A Juste,Elisa Ferreras-Colino,José de la Fuente et al.
Ramón A Juste et al.
Trained immunity (TRAIM) may be defined as a form of memory where innate immune cells such as monocytes, macrophages, dendritic and natural killer (NK) cells undergo an epigenetic reprogramming that enhances their primary defensive capabili...
Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response [0.03%]
细胞因子风暴的诱导涉及骨桥蛋白依赖性T辅助细胞1应答的抑制
Gulimirerouzi Fnu,Kristin Hudock,Margaret Powers-Fletcher et al.
Gulimirerouzi Fnu et al.
Cytokine release syndromes represent a severe turn in certain disease states, which may be caused by several infections, including those with the virus SARS-CoV-2. This inefficient, even harmful, immune response has been associated with a b...
Mineralocorticoid receptor deficiency in Treg cells ameliorates DSS-induced colitis in a gut microbiota-dependent manner [0.03%]
调节性T细胞中盐皮质激素受体缺陷以依赖肠道菌群的方式缓解DSS诱导的结肠炎
Ting Liu,Yu-Lin Li,Lu-Jun Zhou et al.
Ting Liu et al.
Mineralocorticoid receptor (MR) is a classic nuclear receptor and an effective drug target in the cardiovascular system. The function of MR in immune cells such as macrophages and T cells has been increasingly appreciated. The aim of this s...
Multi-responsive mesoporous polydopamine composite nanorods cooperate with nano-enzyme and photosensitiser for intensive immunotherapy of bladder cancer [0.03%]
用于膀胱癌强化免疫治疗的多响应介孔聚多巴胺复合纳米棒与nano-enzyme和photosensitizer协同作用
Xiang Wu,Yongbao Wei,Rongcheng Lin et al.
Xiang Wu et al.
Bladder cancer is a common malignancy in the urinary system. Defects of drug molecules in bladder during treatment, such as passive diffusion, rapid clearance of periodic urination, poor adhesion and permeation abilities, lead to low delive...
Antibody-dependent cell-mediated cytotoxicity using T cells with NK-like phenotype in combination with avelumab, an anti-PD-L1 antibody [0.03%]
一种结合抗PD-L1抗体Avelumab使用的T细胞与NK样表型的抗体依赖性细胞介导的细胞毒性作用
Dong Liu,Yuefeng Hu,Jian Wei et al.
Dong Liu et al.
Though the PD-L1 checkpoint inhibitor avelumab has shown efficacy in the treatment of some types of cancer, improved treatment strategies are desperately needed. We evaluated whether combined treatment with avelumab and adoptively transferr...
Comparison of the immunogenicity of five COVID-19 vaccines in Sri Lanka [0.03%]
斯里兰卡五种新冠肺炎疫苗的免疫原性比较研究
Chandima Jeewandara,Inoka Sepali Aberathna,Saubhagya Danasekara et al.
Chandima Jeewandara et al.
To determine the antibody responses elicited by different vaccines against SARS-CoV-2, we compared antibody responses in individuals 3 months post-vaccination in those who had received different vaccines in Sri Lanka. Abs to the receptor bi...
Comparative Study
Immunology. 2022 Oct;167(2):263-274. DOI:10.1111/imm.13535 2022
A 'waste product' to save the day in the field of transplantation: The evolving potential of extracellular vesicles [0.03%]
废物利用：外泌体让移植研究看见希望
Ioanna Lazana,George Vassilopoulos
Ioanna Lazana
Graft rejection and graft-versus-host disease constitute the leading causes of morbidity and early mortality after solid organ and haematopoietic stem cell transplantation, respectively. Despite the current advances in immunotherapy, their ...