Habib Sadeghirad,Tayyeb Bahrami,Sepideh M Layeghi et al.
Habib Sadeghirad et al.
Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in the world and has a 5-year survival rate of ~20%. Immunotherapies have shown promising results leading to durable responses, however, they are only effective fo...
T-cell immunoglobulin- and mucin-domain-containing molecule-4 maintains adipose tissue homeostasis by orchestrating M2 macrophage polarization via nuclear factor kappa B pathway [0.03%]
T细胞免疫球蛋白和黏膜分子结构域含有一种新的通过NF-κB途径调节M2型巨噬细胞极化来维持脂肪组织稳态的分子-4
Lu Ding,Yan Liang,Yuzhen Wang et al.
Lu Ding et al.
Obesity is generally associated with low-grade inflammation. Adipose tissue macrophages (ATMs) orchestrate metabolic inflammation. The classical (M1-like) or alternative (M2-like) activation of ATMs is functionally coupled with the metaboli...
Oxidative phosphorylation regulates interleukin-10 production in regulatory B cells via the extracellular signal-related kinase pathway [0.03%]
氧化磷酸化通过细胞外信号调节激酶途径调控调节性B细胞中白细胞介素-10的产生
Yinhong Zhu,Xiaoran Zhang,Shujuan Xie et al.
Yinhong Zhu et al.
Regulatory B cells (Bregs) are immune cells that constrain autoimmune response and restrict inflammation via their expression of interleukin (IL)-10. However, the molecular mechanisms underlying Breg differentiation and IL-10 secretion rema...
USP12 positively regulates M-MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65 [0.03%]
USP12通过去泛素化和稳定p65正向调节M-MDSC功能以抑制抗肿瘤免疫反应
Xiaoxia Zhan,Qiuying He,Junli Sheng et al.
Xiaoxia Zhan et al.
The relative abundance of myeloid-derived suppressor cells (MDSCs) compared to cytotoxic T cells determines the outcomes of diseases and the efficacy of immunotherapy. Ubiquitin-specific peptidase 12 (USP12), a member of the USP family of d...
Dopaminergic inhibition of human neutrophils is exerted through D1-like receptors and affected by bacterial infection [0.03%]
多巴胺通过D1样的受体抑制人类中性粒细胞的功能并受到细菌感染的影响
Franca Marino,Monica Pinoli,Emanuela Rasini et al.
Franca Marino et al.
Dopamine (DA) affects immune functions in healthy subjects (HS) and during disease by acting on D1-like (D1 and D5) and D2-like (D2, D3 and D4) dopaminergic receptors (DR); however, its effects on human polymorphonuclear leukocytes (PMN) ar...
Treatment with IgM-enriched intravenous immunoglobulins enhances clearance of stroke-associated bacterial lung infection [0.03%]
静脉注射富含IgM的免疫球蛋白治疗可增强清除卒中相关性细菌肺感染的效果
Laura McCulloch,Alison J Harris,Alexandra Malbon et al.
Laura McCulloch et al.
Post-stroke infection is a common complication of stroke that is associated with poor outcome. We previously reported that stroke induces an ablation of multiple sub-populations of B cells and reduces levels of immunoglobulin M (IgM) antibo...
The efficacy of combined immunotherapy with Propes and Inflamafertin in adult patients with genetic deficiency of the folate cycle and selective deficiency of NK and NKT cells [0.03%]
叶酸循环基因缺陷及自然杀伤细胞和天然 Killer T 细胞选择性免疫缺损成人患者中 Propes 和 Inflamaferon 联合免疫疗法的效果研究
Dmitry Maltsev,Volodymyr Stefanyshyn
Dmitry Maltsev
The purpose of the present study is to evaluate the efficacy of combination immunotherapy with Propes and Inflamafertin in GDFC adults with natural killer (NK) and/or natural killer T-lymphocyte (NKT) cell deficiency. This single-centre, re...
Clinical Trial
Immunology. 2022 Nov;167(3):443-450. DOI:10.1111/imm.13548 2022
Host stimulator of interferon genes is essential for the efficacy of anti-programmed cell death protein 1 inhibitors in non-small cell lung cancer [0.03%]
干扰素基因刺激因子在非小细胞肺癌抗程序性死亡蛋白1抑制剂疗效中不可或缺
Li Zhou,Qiuli Xu,Litang Huang et al.
Li Zhou et al.
The stimulator of interferon genes (STING) pathway is important for anticancer immune responses. However, the relative contributions of host and tumour STING in anti-programmed cell death protein 1 (anti-PD-1) inhibitor responses in non-sma...
Greg M Delgoffe
Greg M Delgoffe
Editorial
Immunology. 2022 Aug;166(4):425-428. DOI:10.1111/imm.13545 2022
Pneumolysin suppresses the initial macrophage pro-inflammatory response to Streptococcus pneumoniae [0.03%]
肺炎链球菌溶血素O通过抑制巨噬细胞初始促炎症反应促进细菌定植和播散
Jimstan Periselneris,Carolin T Turner,Giuseppe Ercoli et al.
Jimstan Periselneris et al.
Published data for the Streptococcus pneumoniae virulence factor Pneumolysin (Ply) show contradictory effects on the host inflammatory response to infection. Ply has been shown to activate the inflammasome, but also can bind to MRC-1 result...