Aging is accompanied by T-cell stiffening and reduced interstitial migration through dysfunctional nuclear organization [0.03%]
衰老通过核结构功能障碍导致T细胞僵硬并减少间质迁移
Blanca González-Bermúdez,Hikaru Kobayashi,Aldo Abarca-Ortega et al.
Blanca González-Bermúdez et al.
Age-associated changes in T-cell function play a central role in immunosenescence. The role of aging in the decreased T-cell repertoire, primarily because of thymic involution, has been extensively studied. However, increasing evidence indi...
Stem cell factor/mast cell/CCL2/monocyte/macrophage axis promotes Coxsackievirus B3 myocarditis and cardiac fibrosis by increasing Ly6Chigh monocyte influx and fibrogenic mediators production [0.03%]
干细胞因子/肥大细胞/CCL2/单核细胞/巨噬细胞轴通过增加Ly6C高的单核细胞浸润和促纤维化介质的产生来促进柯萨奇病毒B3心肌炎和心脏纤维化
Yuan Luo,Hongkai Zhang,Jie Yu et al.
Yuan Luo et al.
Mast cells (MCs), central players in allergy and parasitic infections, play key roles in inflammation and fibrosis. Here, the impact of MCs on the progression of Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) and fibrosis was inve...
β1 Integrin induces adhesion and migration of human Th17 cells via Pyk2-dependent activation of P2X4 receptor [0.03%]
β1整合素通过Pyk2依赖性激活P2X4受体诱导人类Th17细胞粘附和迁移
Chakib Hamoudi,Abbas Muheidli,Fawzi Aoudjit
Chakib Hamoudi
Integrin-mediated T-cell adhesion and migration is a crucial step in immune response and autoimmune diseases. However, the underlying signalling mechanisms are not fully elucidated. In this study, we examined the implication of purinergic s...
Lactoferrin-derived chimeric peptide (LFch) strongly boosts TGFβ1-mediated inducible Treg differentiation possibly through downregulating TCR/CD28 signalling [0.03%]
乳铁蛋白衍生的嵌合肽（LFch）可强力促进TGFβ1介导的诱导型调节性T细胞分化可能通过下调TCR/CD28信号通路实现
Young-Saeng Jang,Seok-Won Yang,Tae-Gyu Kim et al.
Young-Saeng Jang et al.
We recently reported that lactoferrin (LF) induces Foxp3+ Treg differentiation through binding to TGFβ receptor III (TβRIII), and this activity was further enhanced by TGFβ1. Generally, a low T-cell receptor (TCR) signal strength is favo...
Effector Th1 cells under PD-1 and CTLA-4 checkpoint blockade abrogate the upregulation of multiple inhibitory receptors and by-pass exhaustion [0.03%]
PD-1和CTLA-4检查点阻滞效应Th1细胞可消除多个抑制性受体的上调并避开耗竭
Utku Horzum,Hamdullah Yanik,Ekim Z Taskiran et al.
Utku Horzum et al.
Immune checkpoint inhibitor (ICI) immunotherapy relies on the restoration of T-cell functions. The ICI receptors are not only found on exhausted T cells but also upregulated upon activation and reach high levels on effector T cells. In an e...
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway [0.03%]
IKKα通过正向调节Wnt/β-联蛋白信号转导途径促进肾纤维化恶化
Hao Zhang,Binbin Pan,Wenjuan Huang et al.
Hao Zhang et al.
AKI (acute kidney injury) with maladaptive repair plays exacerbated role in renal fibrosis characterized by tubulointerstitial fibrosis. Previously, we reported that IKKα contributed to kidney regeneration and inhibited inflammation. Here,...
Epigenetics: An opportunity to shape innate and adaptive immune responses [0.03%]
表观遗传学：塑造先天性和适应性免疫反应的机会
Antonietta Liotti,Anne Lise Ferrara,Stefania Loffredo et al.
Antonietta Liotti et al.
Epigenetics connects genetic and environmental factors: it includes DNA methylation, histone post-translational modifications and the regulation of chromatin accessibility by non-coding RNAs, all of which control constitutive or inducible g...
Notch1 signalling controls the differentiation and function of myeloid-derived suppressor cells in systemic lupus erythematosus [0.03%]
诺瑟姆信号控制 notch1在系统性红斑狼疮中的髓系衍生抑制细胞的分化和功能
Xiaojing Li,Fei Fei,Genhong Yao et al.
Xiaojing Li et al.
Emerging studies have reported the expansion of myeloid-derived suppressor cells (MDSCs) in some autoimmune disorders, such as systemic lupus erythematosus (SLE), but the detailed molecular mechanisms of the aberrant expansion in SLE are st...
Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis [0.03%]
靶向脱氧胞苷激酶可改善多发性硬化小鼠模型的症状
Bao Ying Chen,Jessica R Salas,Alyssa O Trias et al.
Bao Ying Chen et al.
Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the rate...
The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemic [0.03%]
免疫反应的双刃剑效应：新冠大流行带来的教训
Chiara Agrati,Rita Carsetti,Veronica Bordoni et al.
Chiara Agrati et al.
The COVID-19 pandemic has represented an unprecedented challenge for the humanity, and scientists around the world provided a huge effort to elucidate critical aspects in the fight against the pathogen, useful in designing public health str...