Exercise Duration Modulates Cortisol Release and Chronic Cortisol Exposure Jeopardises T Cell Effector Functions [0.03%]
运动时间调节皮质醇释放和慢性皮质醇暴露损害T细胞效应功能
Thy Viet Luu,Line Fleischer Hach,Tina Seremet et al.
Thy Viet Luu et al.
Psychological stress has been linked to increased incidence and mortality of cancer. During stress, cortisol is released into circulation and regulates cellular processes including immune activity by acting on glucocorticoid receptors (GCRs...
Co-Existence of IL6ST and MEFV Pathogenic Variant in a Patient With Hyper-IgE Syndrome [0.03%]
IL6ST和MEFV致病基因变异与高IgE综合征共存病例报告
Hulya Kose,Muruvvet Yanaz,Akcahan Akalin
Hulya Kose
Ya Li,Xingyue Liu,Feifei Shang et al.
Ya Li et al.
27-Hydroxycholesterol (27-HC) is an oxidative metabolite of cholesterol and an oxysterol catalysed by the mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase (CYP27A1). In addition to inducing the release of eosinophil chemotactic f...
Bronchus-Associated Lymphoid Tissue in Humans-The Past and Recent Research [0.03%]
人类的支气管相关淋巴组织(BALT)——过去和最近的研究
Thomas Tschernig,Reinhard Pabst
Thomas Tschernig
Chidimma F Chude,Jude E Uzonna,Janilyn Arsenio
Chidimma F Chude
Tissue-resident memory T (TRM) cells are a specialised subset of immune cells that remain within tissues, playing a vital role in localised immune defence and long-term immunity. Unlike circulating memory T cells, TRM cells do not recircula...
Review
Immunology. 2025 Aug 3. DOI:10.1111/imm.70024 2025
Oral Treatment With Heat Shock Protein 65-Producing Lactococcus lactis Induces Regulatory T Cells, Modulating Inflammatory Response in Leishmania braziliensis Infection [0.03%]
热休克蛋白65产生乳酸菌口服治疗诱导调节性T细胞，调节巴西利什曼原虫感染的炎症反应
Camila Mattos Andrade,Ítalo da Silva Gonçalves,Maria Luiza das Neves Nascimento et al.
Camila Mattos Andrade et al.
Cutaneous leishmaniasis (CL), a neglected tropical disease prevalent in Brazil, is caused by Leishmania braziliensis (L. braziliensis) and is marked by ulcerative skin lesions and an exacerbated Th1-driven inflammatory response. This study ...
Pyroptosis Drives the Impairment of Colonic Barrier Integrity During Toxoplasma Gondii Chronic Infection [0.03%]
pyroptosis驱动的刚地梭菌慢性感染期间结肠屏障完整性损伤的作用
Xiaokang Tian,Yihui Xing,Yumeng Zhou et al.
Xiaokang Tian et al.
Toxoplasma gondii (T. gondii) impairs gut barrier integrity in hosts, which helps the establishment of long-term infection and is closely associated with disease progression. However, the precise mechanisms remain largely unclear. This stud...
Xinze Li,Xinnan Zhang,Zhiyong Cao et al.
Xinze Li et al.
Immunotherapy has demonstrated groundbreaking clinical efficacy across diverse cancer types. Nevertheless, its therapeutic potential remains constrained, with only a small subset of patients achieving durable clinical responses. Emerging ev...
Review
Immunology. 2025 Jul 24. DOI:10.1111/imm.70020 2025