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27-Hydroxycholesterol Exacerbates the Pathogenesis of Asthma

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27-Hydroxycholesterol (27-HC) is an oxidative metabolite of cholesterol and an oxysterol catalysed by the mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase (CYP27A1). In addition to inducing the release of eosinophil chemotactic factors such as RANTE... ...