Paxbp1 is indispensable for the maintenance of peripheral CD4 T cell homeostasis [0.03%]
Paxbp1对维持外周CD4 T细胞稳态是必不可少的
Wenting Li,Yang Yang,Fan Zhuo et al.
Wenting Li et al.
The size and condition of the peripheral CD4 T cell population determine the capacity of the immune response. Under homeostatic conditions, the size of the peripheral CD4 T cell population is maintained through turnover and survival. Howeve...
Glycans in melanoma: Drivers of tumour progression but sweet targets to exploit for immunotherapy [0.03%]
黑素瘤中的糖链：肿瘤进展的驱动因子但可用于免疫治疗的靶标
Camille Niveau,Eleonora Sosa Cuevas,Philippe Saas et al.
Camille Niveau et al.
Aberrant glycosylation recently emerged as an unmissable hallmark of cancer progression in many cancers. In melanoma, there is growing evidence that the tumour 'glycocode' plays a major role in promoting cell proliferation, invasion, migrat...
Review
Immunology. 2024 May 14. DOI:10.1111/imm.13801 2024
Human CD4+ iNKT cell adoptive immunotherapy induces anti-tumour responses against CD1d-negative EBV-driven B lymphoma [0.03%]
人源CD4+iNKT细胞过继免疫治疗诱导针对EB病毒驱动的B淋巴瘤(即使CD1d阴性)的抗肿瘤反应
Dana C Baiu,Akshat Sharma,Jennifer L Schehr et al.
Dana C Baiu et al.
Invariant natural killer T (iNKT) cells are a conserved population of innate T lymphocytes that are uniquely suitable as off-the-shelf cellular immunotherapies due to their lack of alloreactivity. Two major subpopulations of human iNKT cell...
The powerful potential of amino acid menthyl esters for anti-inflammatory and anti-obesity therapies [0.03%]
氨基酸薄荷酯在抗炎和治肥胖方面的潜力
Seidai Takasawa,Kosuke Kimura,Masato Miyanaga et al.
Seidai Takasawa et al.
Our newly developed menthyl esters of valine and isoleucine exhibit anti-inflammatory properties beyond those of the well-known menthol in macrophages stimulated by lipopolysaccharide (LPS) and in a mouse model of colitis induced by sodium ...
FG-4592 protected haematopoietic system from ionising radiation in mice [0.03%]
FG-4592可保护小鼠造血系统免受电离辐射损害
Yuedong Wang,Ying Cheng,Pei Zhang et al.
Yuedong Wang et al.
Ionising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Admi...
Unravelling CD4+ T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing [0.03%]
通过单细胞测序解析降主动脉瘤中CD4+T细胞的多样性及Tregs的组织特异性适应性
Luna Zhai,Wangling Hu,Jingyong Li et al.
Luna Zhai et al.
Immune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4+ T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tr...
Oligodeoxynucleotides containing CpG motifs (CpG-ODN) restores immune regulatory functions of airway macrophages of patients with asthma [0.03%]
含CpG motives的寡脱氧核苷酸(CpG-ODN)可恢复哮喘患者气道巨噬细胞免疫调节功能
Huanping Zhang,Lihuan Wang,Aizhi Zhang et al.
Huanping Zhang et al.
Allergic asthma is characterized by the polarization of Th2 cells and impaired immune regulation. Macrophages occupy the largest proportion of airway immune cells. This study aims to discover the mechanism that hinders the immune regulatory...
TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS [0.03%]
miR-146a-3p通过激活TLR8参与细菌LPS诱导的胎膜炎症反应
Hanah M Georges,Caterina Cassin,Mancy Tong et al.
Hanah M Georges et al.
Preterm birth is the largest contributor to neonatal morbidity and is often associated with chorioamnionitis, defined as inflammation/infection of the fetal membranes (FMs). Chorioamnionitis is characterised by neutrophil infiltration of th...
The TRIF-RIPK1-Caspase-8 signalling in the regulation of TLR4-driven gene expression [0.03%]
TRIF-RIPK1-Caspase-8信号轴调节TLR4驱动的基因表达
Chengyang Zhang,Yang Zhou,Shuangtong Xi et al.
Chengyang Zhang et al.
The inflammatory response is tightly regulated to eliminate invading pathogens and avoid excessive production of inflammatory mediators and tissue damage. Caspase-8 is a cysteine protease that is involved in programmed cell death. Here we s...
Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy [0.03%]
免疫疗法与卵巢癌微环境：探索增强治疗效果的潜在策略
Zhi-Bin Wang,Xiu Zhang,Chao Fang et al.
Zhi-Bin Wang et al.
Despite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex tumour microenvironment, contribute to this unfavourabl...
Review
Immunology. 2024 Apr 15. DOI:10.1111/imm.13793 2024