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The TRIF-RIPK1-Caspase-8 signalling in the regulation of TLR4-driven gene expression

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The inflammatory response is tightly regulated to eliminate invading pathogens and avoid excessive production of inflammatory mediators and tissue damage. Caspase-8 is a cysteine protease that is involved in programmed cell death. Here we show the TRIF-RIPK1-C... ...