Epsin 3 Promotes Cellular Senescence Through Reactive Oxygen Species-Mediated Induction of DNA Damage [0.03%]
Epsin 3通过活性氧介导的DNA损伤诱导促进细胞衰老
Yukihiro Ikegaki,Anju Terachi,Shunsuke Yamao et al.
Yukihiro Ikegaki et al.
Cellular senescence is caused by various stresses, including DNA damage, oxidative stress, oncogene activation, and telomere shortening. However, the detailed molecular mechanisms of cellular senescence have yet to be elucidated. Recently, ...
TIE1 Promotes Primary Tumor Growth by Inhibiting Apoptosis and Activating the AKT-p70S6K Signaling Pathway in Breast Cancer [0.03%]
TIE1通过抑制乳腺癌中的凋亡及激活AKT-p70S6K信号通路促进原发肿瘤生长
Kazushi Azuma,Takaya Matsuyama,Shinya Watanabe et al.
Kazushi Azuma et al.
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype among all breast cancer types. Its treatment remains a significant challenge due to the lack of clearly defined molecular targets. We previously reported that lun...
Condensin-Condensin Interactions Facilitate Mitotic Chromosome Assembly in Xenopus Egg Extracts [0.03%]
非洲爪蟾卵母细胞提取物中condensin-condensin相互作用促进有丝分裂染色体的组装
Kazuhisa Kinoshita,Yuuki Aizawa,Tatsuya Hirano
Kazuhisa Kinoshita
Condensins are large protein complexes that play a central role in mitotic chromosome assembly in eukaryotes. Our previous mutational analyses of condensin I, combined with Xenopus egg cell-free extracts, provided evidence that dynamic cond...
Combinatorial Analyses of Pre-mRNA Splicing-Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions [0.03%]
对剪接缺陷突变体的组合分析揭示了染色体端粒体在不同端粒功能中的定量需求差异
Miho Takeuchi,Yoko Otsubo,Junko Kanoh
Miho Takeuchi
Telomeres perform multiple functions to maintain genome stability, including telomere length regulation, chromosome end protection, and meiotic chromosome dynamics. These functions are governed by shelterin, a telomere-binding protein compl...
Removing Extracellular Matrix From the Cell Surface Prior to Seeding Enhances the Adhesion of Primary Human Hepatocytes to the Culture Vessel [0.03%]
播种前去除细胞表面的胞外基质可增强原代人肝细胞对培养容器的粘附性
Manami Miyai,Rieko Tanaka-Yachi,Kazuko Aizawa et al.
Manami Miyai et al.
Primary human hepatocytes (PHHs) are currently the gold standard for developing human-relevant in vitro liver cell culture models for studies of pathological conditions, compound screening, and metabolism and toxicity testing in the drug di...
Cell Surface LAMP-2C Is Internalized in a Clathrin-Dependent Manner and Transported to the Recycling and Lysosomal Pathways [0.03%]
细胞表面LAMP-2C通过依赖于网格蛋白的方式内吞并被运输到循环和溶酶体途径中
Hiroshi Sakane,Yuna Takeda,Ikuto Okuda et al.
Hiroshi Sakane et al.
Lysosomes are acidic organelles that degrade a diverse range of substrates, and lysosome-associated membrane protein (LAMP)-1 and LAMP-2 are the major lysosomal membrane components. Three LAMP-2 splice variants have been identified, namely,...
Yoshifumi Saito,Akari Obayashi,Riho Ichikawa et al.
Yoshifumi Saito et al.
Hepatocellular carcinoma (HCC) is a prevalent and deadly cancer worldwide, characterized by poor prognosis, multiple therapeutic challenges, and considerable heterogeneity among patients with diverse etiologies. This heterogeneity contribut...
Development of a Novel Mucosal Vaccine Vector Derived From Human Parainfluenza Virus Type 2 and Its Efficacy as a SARS-CoV-2 Vaccine by Intratracheal Administration Using Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 [0.03%]
基于人副流感病毒2型开发的新型粘膜疫苗载体及其作为SARS-CoV-2疫苗通过表达人ACE2转基因小鼠经气管途径给药的有效性研究
Akira Kawano,Masamitsu N Asaka,Mitsuo Kawano et al.
Akira Kawano et al.
We created a novel replication-incompetent vector derived from the human parainfluenza virus type 2 (hPIV2). The vector lacks the hemagglutinin-neuraminidase (HN) gene (hPIV2/∆HN) that is essential for virus attachment and release. We also...