Characterization of Nucleobase Cation Symporter 1 (NCS1) Localized to the Plastids of Nicotiana tabacum [0.03%]
烟草烟草原叶绿体定殖的嘌呤碱基阳离子转运蛋白1(NCS1)的性质刻画
Nobukazu Shitan,Shota Minami,Taku Tsuyama et al.
Nobukazu Shitan et al.
Jasmonate-mediated defense responses redirect plant resources from growth to defense, imposing significant demands on the nitrogen economy to produce nitrogenous compounds, such as alkaloids. However, the mechanisms by which plants maintain...
Treatment With Ruxolitinib and TAK-779 Enhances GII.17 Human Norovirus Replication and Enables Serial Passaging in Human Intestinal Enteroids [0.03%]
鲁索利替尼和TAK-779治疗增强GII.17型人类诺如病毒的复制并使其能够在人类肠类器官中连续传代培养
Eri Hiraishi,Tsuyoshi Hayashi,Yoshiki Fujii et al.
Eri Hiraishi et al.
Human norovirus (HuNoV) is a major cause of acute viral gastroenteritis. Although it can be replicated in vitro using human intestinal enteroids (HIEs), generating high-titer viral laboratory stocks remains challenging due to low infection ...
Combined Inhibition of Wee1 and Checkpoint Kinases Synergistically Provokes S-Phase Progression and Mitotic Entry, and Promotes Cell Death Under Heat Stress [0.03%]
Wee1和检查点激酶联合抑制协同促进S期进程和有丝分裂的进入，并在热应力下促进细胞死亡
Tamaki Muratani,Honoka Takeya,Riko Ishibashi et al.
Tamaki Muratani et al.
Hyperthermia, induced by heat stress (HS), inhibits cancer cell proliferation and induces cell death. We have previously demonstrated that the inhibition of checkpoint kinase 1/2 (Chk1/2) abrogated G2/M arrest and promoted cell death under ...
RNA-Seq Profiling Reveals Transcriptional Changes in Phosphorylation-Site Mutants of Brg1 [0.03%]
利用RNA-Seq技术分析Brg1磷酸化位点突变引起的转录变化
Ayuko Kimura,Jun Nakabayashi,Osamu Ohara et al.
Ayuko Kimura et al.
Brg1 is a core ATPase subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex that regulates DNA accessibility for RNA polymerase II (Pol II), transcription factors, and DNA repair enzymes. Phosphoproteomic prof...
Cancer-Associated STAT3 Mutations Maintain ES Cell Self-Renewal Through Phosphorylation-Independent Mechanisms [0.03%]
STAT3癌基因突变通过非磷酸化依赖机制维持胚胎干细胞自我更新作用
Tadayuki Akagi,Shota Nakamura,Tomoya Tamaru et al.
Tadayuki Akagi et al.
Signal transducer and activator of transcription 3 (STAT3) is essential for embryonic stem (ES) cell self-renewal, and its mutations are found in various human diseases. In this study, we investigated the effects of disease-associated STAT3...
A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts [0.03%]
SEPTIN9和MSX1基因变异组合导致唇腭裂形成
Udval Uuganbayar,Zarko Manojlovic,Nao Ito et al.
Udval Uuganbayar et al.
Nonsyndromic cleft lip with or without palate (nCL/P) is a common congenital anomaly with a complex genetic basis. Previous whole-exome sequencing of Malagasy case-parent trios identified variants in several craniofacial development genes, ...
The Nuclear Export Signal of IκBα Drives RelB Oscillations in the Noncanonical NF-κB Pathway [0.03%]
IκBα的核输出信号通过非经典NF-κB途径驱动RelB振荡
Takao Seki,Shelly Davis,Shigeki Miyamoto et al.
Takao Seki et al.
The noncanonical NF-κB pathway regulates immune development and inflammation through RelB nuclear translocation, yet the dynamics of this process at the single-cell level remain poorly understood. Using live-cell imaging of RelB-Venus knoc...
The SQSTM1 L341V Variant Associated With Sporadic ALS Promotes the Accumulation of Enlarged Ubiquitin-Positive SQSTM1 Bodies [0.03%]
SQSTM1变异体L341V促进巨大型泛素阳性SQSTM1包涵体聚集与散发性ALS相关
Kento Shimakura,Akira Oka,Haruka Yudahira et al.
Kento Shimakura et al.
SQSTM1 is one of the causative genes of neurodegenerative disorders, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The SQSTM1 protein regulates the degradation of polyubiquitinated proteins and autophagosome formati...
Partial Depletion of SART1 Selectively Induces Mitotic Defects and Cell Death in Cancer Cells [0.03%]
SART1的部分耗竭选择性地诱导癌细胞有丝分裂缺陷和细胞死亡
Hideki Yokoyama,Saito Akatsu,Kotaro Hayakawa
Hideki Yokoyama
Cancer cells proliferate uncontrollably, and a major challenge in cancer research is to identify strategies that selectively eliminate cancer cells while sparing normal cells. Squamous cell carcinoma antigen recognized by T cells 1 (SART1) ...