Hijiri Yoshida,Takashi Suto,Hiroyuki Hirano et al.
Hijiri Yoshida et al.
GPR151 is an orphan G-protein-coupled receptor expressed on specific neurons. Its expression has been reported to be upregulated in the dorsal root ganglia in mouse nerve injury models, suggesting a role in pain transmission. We used our un...
POU5F1/OCT4 Attenuates Human LINE-1 Expression Levels in Induced Pluripotent Stem Cells [0.03%]
OCT4通过表观遗传调控抑制人诱导多能干细胞中的LINE-1元件表达水平
Hikaru Suzuki,Kenji Ichiyanagi
Hikaru Suzuki
Long interspersed nuclear element-1 (LINE-1, L1) shows high transcriptional activity in human pluripotent stem cells (PSCs). Here, we showed that pluripotency-associated transcription factors (TFs) such as POU5F1 (OCT4), SOX2, KLF4, NANOG, ...
Liver-Specific Deletion of Cnot11 Delays Postnatal Hepatocyte Maturation and Transiently Impairs Liver Function in Mice [0.03%]
Cnot11肝细胞特异性敲除延迟小鼠肝脏成熟并短暂损害肝功能
Saori Nishijima,Toru Suzuki,Takaya Abe et al.
Saori Nishijima et al.
The CCR4-NOT complex is a central regulator of post-transcriptional gene expression that controls mRNA deadenylation and decay. Although the catalytic subunits have been well characterized, the physiological roles of several non-catalytic s...
Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts [0.03%]
组蛋白密度和动态特性塑造非洲爪蟾卵母细胞提取物有丝分裂染色单体的结构
Keishi Shintomi,Keita Ohsumi,Mari Iwabuchi et al.
Keishi Shintomi et al.
Mitotic chromosomes, consisting of a pair of rod-shaped chromatids, emerge from a dramatic reorganization of nucleosome fibers. However, the mechanisms by which local chromatin organization influences large-scale mitotic chromatid architect...
Comparative Analysis of Closely Related Class XI Myosins Reveals Molecular Determinants of Actin Trajectory Curvature [0.03%]
对密切相关类XI肌球蛋白的比较分析揭示了 actin 轨迹曲率的分子决定因素
Kohei Yoshimura,Takuma Imi,Taisei Nagai et al.
Kohei Yoshimura et al.
Left-right asymmetry in multicellular organisms is often rooted in cellular chirality emerging from asymmetric actin cytoskeleton dynamics. Although several myosins exhibit chiral actin motility in vitro, the molecular determinants regulati...
Pharmacological Correction of Aberrant DSCAML1 Localization by 4-Phenylbutyrate Ameliorates Epileptic Phenotypes in a Mouse Model Harboring the Patient-Specific A2105T Mutation [0.03%]
4-苯基丁酸药理学矫正异常定位的DSCAML1改善携带患者特异性A2105T突变小鼠模型的癫痫表型
Yoneko Hayase,Tomoo Owa,Koichi Hashizume et al.
Yoneko Hayase et al.
DSCAML1 variants are associated with neurodevelopmental disorders and epilepsy. The pathogenic A2105T missense mutation leads to intracellular accumulation of the DSCAML1 protein, preventing its proper localization to the cell surface. Here...
Mislocalized Cytosolic Polyphosphate Forms Potentially Toxic Droplets, Highlighting the Essentiality of Vacuolar Polyphosphate in Pi Homeostasis [0.03%]
细胞溶质多聚磷酸盐的误定位可能形成潜在有毒的凝聚体，强调了液泡内多聚磷酸盐在维持Pi稳态中的重要性
Kojiro Takeda,Rumi Okuyama,Hiyori Takechi et al.
Kojiro Takeda et al.
Inorganic polyphosphate is a phosphate polymer found in nearly all species examined to date. Over decades of research, this biopolymer has been revealed to participate in a broad range of biological phenomena, from phosphate storage to huma...
Gene Expression Profiles Reveal Altered Metabolic Signaling Pathway in Skeletal Muscle With Lipid Sensor Gpr120/Ffar4 Deficiency [0.03%]
基因表达谱揭示了脂质传感器GPR120/FFAR4缺乏对骨骼肌中代谢信号通路的影响
Junfeng Shi,Taito Nakayama,Keiko Iida et al.
Junfeng Shi et al.
Obesity is driven by a chronic imbalance between energy intake and energy expenditure (EE), and reduced EE has been implicated in its development. We previously demonstrated that deficiency of Gpr120/Ffar4, a lipid sensor, led to decreased ...
Historical Dynamics of Transposable Elements in Herbarium Specimens of Arabidopsis thaliana Collected in Germany [0.03%]
来自德国标本馆的拟南芥转座子历史动态研究
Akio Miyao
Akio Miyao
The dynamics of plant genomes under natural environmental conditions represent a compelling area of research. Among these, transposition events involving transposable elements (TEs) are of particular interest, as they can disrupt gene funct...
Attenuation of Oxygen-Induced Neovascularization and Inflammation by Neutralizing VEGFA and/or ANG-2 With an Antibody [0.03%]
一种中和VEGFA和ANG-2的抗体对氧诱导视网膜病变新生血管及炎症的影响
Hirokazu Oohashi,Toshiro Iwagawa,Hiroto Abe et al.
Hirokazu Oohashi et al.
Neovascularization is a major cause of blindness in various retinal diseases, and inflammation aggravates the pathological and clinical conditions of these diseases. VEGFA or ANG-2 neutralizing antibodies have been used to block pathologica...