AlphaFold2 Insights into c-Abl Transactivation by Adaptor c-Crk or Abi-1: Structural Forms, Active Site Types, and Multiple SH3-PxxPxK/R Interactions
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This study used AlphaFold2 to investigate allosteric structural changes during c-Abl transactivation. Two structural forms of c-Abl (positions of SH2 and SH3 domains relative to kinase domain) and four active site types (types 0-3) were identified. Key interac... ...
