Mechanisms Underlying Aberrant Splicing of Transcripts From the Intron-Less Coding Sequence of SPCA1 [0.03%]
SPCA1无内含子编码序列的转录本异常剪接机制研究
Sachiko Yamamoto-Hijikata,Kei Suga,Takuya Sakurai et al.
Sachiko Yamamoto-Hijikata et al.
In protein expression systems, only the protein-coding sequence (CDS) of the gene is inserted in the vector, producing intron-less mRNA that is translated directly without splicing. We found that, on expression of the CDS of the Ca2+/Mn2+ p...
A Gly-to-Ala Substitution Confers Choline Phosphotransferase Activity on the CDP-Ethanolamine-Specific Mammalian EPT1 [0.03%]
甘氨酸到丙氨酸的替换使哺乳动物EPT1具有胆碱磷酸转移酶活性
Yasuhiro Horibata,Shoji Maeda,Akimitsu Konishi
Yasuhiro Horibata
Choline phosphotransferase (CPT) and ethanolamine phosphotransferase (EPT) catalyze the synthesis of choline and ethanolamine phospholipids using CDP-choline or CDP-ethanolamine as substrates, respectively. Although both enzymes share the C...
SRscore: An R Package for Quantifying Gene Stress Responsiveness Across Multiple Transcriptome Datasets Using Meta-Analysis [0.03%]
基于元分析计算多个转录组数据集中基因应激反应性的R包SRscore
Yusuke Fukuda,Atsushi Fukushima
Yusuke Fukuda
Meta-analysis is a powerful statistical approach for integrating multiple datasets, being increasingly applied in genome research. Transcriptome meta-analysis provides valuable insights into the functions of stress-responsive genes. In an e...
Refined Modulation of Natural Killer Cells by Transforming Growth Factor-β Isoforms [0.03%]
转化生长因子-β亚型精细调节自然杀伤细胞功能
Kaku Goto,Ryo Amano,Yoshikazu Nakamura et al.
Kaku Goto et al.
Natural killer (NK) cells constitute the vital first line of defense against tumors and have demonstrated promising therapeutic efficacy in the treatment of multiple types of cancer. Meanwhile, the tumor microenvironment impedes anticancer ...
Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP-1 [0.03%]
人表皮成纤维细胞衰老通过BMP-1下调诱导I型胶原异质性成熟及排列畸形
Koji Moriya,Yuki Shibaike,Katsura Sano et al.
Koji Moriya et al.
Considering that the body accumulates senescent fibroblasts during the progression of aging, the character of collagen fibrils secreted from the senescent cells associates with the skin condition. In this study, we examined the alteration o...
A Temperature Increase Induces Atf1/Pcr1-Dependent Rapid Depletion of Histones in Transcriptionally Activated Gene Bodies in Fission Yeast [0.03%]
温度升高通过Atf1/Pcr1依赖性诱导模式迅速降低裂殖酵母转录激活基因体中的组蛋白含量
Arata Hoshino,Takuya Kajitani,Masaya Oki et al.
Arata Hoshino et al.
Transcriptional regulation is central to organisms' response and adaptation to environmental changes. However, the coordination of transcriptional machinery with chromatin when rapid transcriptional changes are needed is largely unknown. He...
ERSAtool: A User-Friendly R/Shiny Comprehensive Transcriptomic Analysis Interface Suitable for Education [0.03%]
ERSA工具：一种用户友好的R / Shiny综合转录组分析界面，适合教育使用
Sujith Taridalu,Ayyappa Kumar Sista Kameshwar,Masako Suzuki
Sujith Taridalu
RNA sequencing (RNA-seq) has become an essential technology for assessing gene expression profiles in biomedical research. However, the coding complexity of RNA-seq data analysis remains a significant barrier for students and researchers wi...
Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium [0.03%]
Foxg1通过维持嗅粘膜中神经发生干细胞潜能来定义 ventrolateral 域身份
Anzu Kuriyama,Yuta Furusho,Carina Hanashima
Anzu Kuriyama
The mammalian olfactory epithelium is composed of neurons and supporting cells organized into distinct zones that enable parallel processing of innate and experience-dependent odor information. Despite its well-defined architecture, the mec...