Alternative Splicing of FBLN2 Generates a Prometastatic Extracellular Matrix in Gastrointestinal Cancers by Determining N-Glycosylation of Fibulin 2 [0.03%]
通过决定纤维连接蛋白2的N-糖基化，FBLN2的选择性拼接在胃肠道癌症中产生了一种促进转移的细胞外基质
Ryo Funayama,Yujue Wang,Masaki Hosogane et al.
Ryo Funayama et al.
Fibulin 2 (FBLN2) is an extracellular matrix glycoprotein. Exclusion of exon 9 of FBLN2 is one of the most recurrent splicing events across multiple types of cancer, but its functional relevance in cancer has remained unexplored. We here re...
Polished Rice Regulates Maturation but Not Survival of Secondary Cells in Drosophila Male Accessory Gland [0.03%]
精米调节果蝇次级细胞的成熟但不影响其存活率
Shinichi Otsune,Mirai Matsuka,Chisato Shirakashi et al.
Shinichi Otsune et al.
In Drosophila males, the accessory gland is responsive to nutrient signal-dependent regulation of fertility/fecundity. The accessory gland is composed of two types of binucleated epithelial cells, about 1000 main cells and 60 secondary cell...
Profiling of RBM20-Regulated CaMKIIδ Splice Variants Across the Heart, Skeletal Muscle, and Olfactory Bulbs [0.03%]
RBM20调节的CaMKIIδ剪接变异体在心脏、骨骼肌和嗅球中的谱型分析
Yui Maeda,Yuri Yamasu,Hidehito Kuroyanagi
Yui Maeda
Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ), encoded by the Camk2d gene, plays key regulatory roles in various Ca2+-regulated cellular processes. Extensive alternative splicing of the Camk2d gene generates multiple CaMKIIδ ...
Characteristics of Global Methylation Changes in F1 Mice Sperm DNA Induced by Gestational Arsenic Exposure Are Re-Established in F2 Somatic Cells but Not in F2 Germ Cells [0.03%]
妊娠期砷暴露的小鼠F1代精子DNA甲基化改变特征在F2代体细胞中再现但不在生殖细胞中再现
Takehiro Suzuki,Kazuyuki Okamura,Keiko Nohara
Takehiro Suzuki
Gestational exposure to chemicals has been reported to transmit epigenetic modifications of germ cells not only to somatic cells but also to the germ cells of the next generation, resulting in adverse effects. Arsenic is one of the environm...
Iron-Dependent JMJD1A-Mediated Demethylation of H3K9me2 Regulates Gene Expression During Adipogenesis in a Spatial Genome Organization-Dependent Manner [0.03%]
铁依赖的JMJD1A介导的H3K9me2脱甲基化以空间基因组组织依赖的方式调控脂肪细胞分化过程中的基因表达
Shinnosuke Masuda,Tetsuro Komatsu,Safiya Atia et al.
Shinnosuke Masuda et al.
Chromatin restructuring across multiple hierarchical scales directs lineage-specific gene expression during cell differentiation. Here, we investigated the iron-dependent demethylation of histone H3 lysine 9 dimethylation (H3K9me2) by the d...
Suguru Hatazawa,Yoshiyuki Fukuda,Yuki Kobayashi et al.
Suguru Hatazawa et al.
In eukaryotic cells, genomic DNA is compacted by nucleosomes, as basic repeating units, into chromatin. The nucleosome arrangement in chromatin fibers could be an important determinant for chromatin folding, by which genomic DNA is regulate...
The 12th 3R + 3C International Symposium: A Meeting for Research Into DNA Replication, Repair, and Recombination, as Well as Chromatin, Chromosomes, and the Cell Cycle [0.03%]
第十二届3R+3C国际研讨会：DNA复制、修复和重组以及染色质、染色体和细胞周期研究会议
Tsutomu Katayama,Masatoshi Fujita,Tatsuro S Takahashi
Tsutomu Katayama
The 12th 3R + 3C international symposium focused on cutting-edge research into the molecular mechanisms and regulatory systems of DNA replication, repair, and recombination (3R) as well as those of chromatin dynamics, chromosome architectur...
INTS15, A Subunit of the Integrator Complex, Plays a Key Regulatory Role in Cell Cycle and Differentiation [0.03%]
INTS15：整合器复合体的一个亚基，在细胞周期和分化中起关键调控作用
Noriyuki Azuma,Yuki Yamaguchi,Taku Tanaka et al.
Noriyuki Azuma et al.
We previously reported that Integrator complex subunit 15 (INTS15) is a causative gene for an autosomal-dominant eye disease named variable panocular malformations (VPMs) and that INTS15 stably interacts with the Integrator complex to suppo...
The Impact of the DNA Topoisomerase IIβ C-Terminal Region on the Selective Degradation Induced by ICRF-193 Treatment [0.03%]
DNA拓扑异构酶IIβ羧基末端区域对ICRF-193处理诱导的选择性降解的影响
Shinji Kawano,Shogo Ikeda
Shinji Kawano
ICRF-193, a catalytic inhibitor of DNA topoisomerase II (TOP2), induces the formation of the TOP2 closed-clamp intermediate. Only the ICRF-193-induced topoisomerase IIβ (TOP2B) closed clamp is known to be selectively and rapidly degraded i...