Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis [0.03%]
蛋白组分析揭示了多发性硬化症患者外周血中性粒细胞的紊乱状态
Katie J Smith,Zachary Lim,Sonja Vermeren et al.
Katie J Smith et al.
Introduction: Multiple Sclerosis (MS) is a complex auto-inflammatory disease affecting the brain and spinal cord, which results in axonal de-myelination and symptoms including fatigue, pain, and difficulties with vision a...
Investigating T cell-derived extracellular vesicles as biomarkers of disease activity, axonal injury, and disability in multiple sclerosis [0.03%]
探究T细胞来源的胞外囊泡作为多发性硬化症疾病活动、轴突损伤和残疾生物标志物的价值
Jennifer L Zagrodnik,Stephanie N Blandford,Neva J Fudge et al.
Jennifer L Zagrodnik et al.
Introduction: Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the CNS, whereby clinical disease activity is primarily monitored by magnetic resonance imaging (MRI). ...
Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cells [0.03%]
单细胞分析揭示了肺上皮细胞中纤毛细胞对SARS-CoV-2感染的年龄和细胞群体特异性反应
Raven M Osborn,Christopher S Anderson,Justin R Leach et al.
Raven M Osborn et al.
Introduction: The ability of SARS-CoV-2 to evade antiviral immune signaling in the airway contributes to the severity of COVID-19 disease. Additionally, COVID-19 is influenced by age and has more severe presentations in o...
Neuro-Behçet's disease: an update of clinical diagnosis, biomarkers and immunopathogenesis [0.03%]
神经贝赫切特病：临床诊断、生物标志物和免疫病理生理的最新研究进展
Haoting Zhan,Linlin Cheng,Yongzhe Li
Haoting Zhan
Neuro-Behçet's disease (NBD) is a more severe but rare symptom of Behçet's disease (BD), which is mainly divided into parenchymal NBD (p-NBD) involving brain stem, spinal cord, and cerebral cortex. Non-p-NBD manifests as intracranial aneu...
Geographic disparities impacting oral vaccine performance: Observations and future directions [0.03%]
地缘因素对口服疫苗效力的影响：现状与未来研究方向
Rachel M Burke,Sasirekha Ramani,Julia Lynch et al.
Rachel M Burke et al.
Oral vaccines have several advantages compared with parenteral administration: they can be relatively cheap to produce in high quantities, easier to administer, and induce intestinal mucosal immunity that can protect against infection. Thes...
The Potential Of Autologous Patient-Derived Circulating Extracellular Vesicles To Improve Drug Delivery In Rheumatoid Arthritis [0.03%]
自身患者衍生的循环细胞外囊泡改善类风湿性关节炎药物递送的潜力
Ori Moskovitch,Adi Anaki,Tal Caller et al.
Ori Moskovitch et al.
Recognizing the need for innovative therapeutic approaches in the management of autoimmune diseases , our current investigation explores the potential of autologous extracellular vesicles (EVs), derived from blood of rheumatoid arthritis (R...
A multi-centre UK-based survey on angioedema secondary to acquired C1 inhibitor deficiency [0.03%]
一项基于英国的多中心调查：获得性C1酯酶抑制剂缺乏继发性血管水肿
Hadeil Morsi,Aarnoud Huissoon,Alexandros Grammatikos et al.
Hadeil Morsi et al.
Background: Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared to its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK is required to inform m...
Mouse CD8+ T cell subsets differentially generate IL-17-expressing cells in the colon epithelium and lamina propria [0.03%]
小鼠结肠上皮和固有层CD8+t细胞亚群分化生成表达IL-17的细胞能力不同
Cunjin Ge,Qiaoyun Tong,Shihua Zheng et al.
Cunjin Ge et al.
Colon-resident CD8+ T cells actively contribute to gut homeostasis and the pathogenesis of inflammatory bowel disease. However, their heterogeneity in generating IL-17-expressing CD8+ T cells, i.e. Tc17 cells, has not been thoroughly reveal...
J Trayer,J M Isaza-Correa,L A Kelly et al.
J Trayer et al.
Neutrophils are short-lived cells of the innate immune system and represent 50-70% of the circulating leucocytes. Their primary role is antimicrobial defence which they accomplish through rapid migration to sites of inflammation followed by...
Type I interferon and mitochondrial dysfunction are associated with dysregulated cytotoxic CD8+ T cell responses in juvenile systemic lupus erythematosus [0.03%]
I型干扰素和线粒体功能障碍与儿童系统性红斑狼疮中细胞毒性CD8+T细胞反应失调有关
Anna Radziszewska,Hannah Peckham,Restuadi Restuadi et al.
Anna Radziszewska et al.
Juvenile systemic lupus erythematosus (JSLE) is an autoimmune condition which causes significant morbidity in children and young adults and is more severe in its presentation than adult-onset SLE. While many aspects of immune dysfunction ha...