Post-translational modifications in extracellular microvesicles from plasma of Rheumatoid Arthritis patients following anti-TNFα therapy [0.03%]
抗TNFα治疗后类风湿关节炎患者血浆外泌体中蛋白质翻译后修饰的变化
S Recalchi,G Riitano,F Ucci et al.
S Recalchi et al.
Introduction: Autoantibodies targeting post-translational modified proteins represent key immunological hallmarks of Rheumatoid Arthritis (RA). In a previous study we demonstrated the presence of citrullinated and carbamy...
Hereditary Angioedema: On-demand Treatment and Long-term Prophylaxis - A Global Reality [0.03%]
遗传性血管水肿：按需治疗和长期预防——全球现状
Cassim Akhoon,Sorena Kiani-Alikhan
Cassim Akhoon
Hereditary Angioedema (HAE) is a rare disorder of recurrent swellings of the subcutaneous and/or mucosal tissues due to defects in the contact system regulation of bradykinin production. The swellings can be disfiguring, cause debilitating ...
The silent regulators: non-coding RNAs and Epstein-Barr virus at the crossroads of lupus pathogenesis [0.03%]
沉默的调控因子：非编码RNA和EB病毒在自身免疫性疾病的交汇点
Andrea Picchianti-Diamanti,Alessandra Rai,Stella Mrmić et al.
Andrea Picchianti-Diamanti et al.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease driven by immune dysregulation, chronic inflammation, and loss of immune tolerance. Increasing evidence suggests that non-coding RNAs (ncRNAs), including microRNAs, lo...
Targeting redox imbalance through Nrf2 activation in the inflamed coeliac duodenum [0.03%]
通过激活Nrf2作用于克罗恩病十二指肠患者的氧化还原失衡
Heather Loughnane,Shrikanth Chomanahalli Basavarajappa,Anna Dominik et al.
Heather Loughnane et al.
Coeliac Disease (CeD) is a chronic gastrointestinal inflammatory disease initiated by dietary gluten in genetically predisposed individuals. While the inflammatory processes which drive tissue destruction in the coeliac duodenum have been e...
Dermatomyositis is characterized by TYK2-dependent STAT3 activation [0.03%]
TYK2依赖的STAT3活化具有 dermatomyositis特征
M Fornaro,S Del Vescovo,F Cacciapaglia et al.
M Fornaro et al.
Dermatomyositis (DM) is characterized by activation of cytokine pathways that signal through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) axis, although the relative contribution of individual JAK family memb...
Helios expression in naïve CD4+ T cells decreases from neonates to older adults [0.03%]
helios在初始态CD4+T细胞中的表达从婴幼儿到老年人逐渐下降
Hiroshi Mutoh,Takeo Mukai,Atsushi Ito et al.
Hiroshi Mutoh et al.
Introduction: Fetuses, neonates, and infants are vulnerable to infectious diseases. At the same time, they are exposed to many harmless antigens; therefore, suppressing unnecessary immune responses to maintain immune tole...
Hacer Neslihan Bildik,Ismail Yaz,Saliha Esenboga et al.
Hacer Neslihan Bildik et al.
Introduction: Immune dysregulation (ID), defined as aberrant immune activation or suppression, may result in autoimmune or inflammatory disorders, lymphoproliferative malignancies, and allergic diseases. Apoptosis, nuclea...
The many faces of cytokine storm syndrome: immunopathogenic mechanisms and clinical implications for a better patient management [0.03%]
细胞因子风暴综合征的多种临床表现：免疫病理机制及对患者更好管理的临床意义
Piero Ruscitti
Piero Ruscitti
Cytokine storm syndrome is a life-threatening hyperinflammatory condition characterized by excessive and dysregulated immune activation, leading to multiorgan dysfunction and poor clinical outcomes if not promptly recognized and adequately ...
PD-1 Engagement and Circulating Th17 Effector Activity During Secukinumab Treatment in Plaque Psoriasis [0.03%]
苏金单抗治疗银屑病患者时PD-1结合与循环Th17效应细胞活性之间的关系
Mengmeng Zhang,Xujiao Feng,Kexiang Yan et al.
Mengmeng Zhang et al.
Introduction: Plaque psoriasis (PP) is a chronic immune-mediated inflammatory disease driven by dysregulation of the IL-23/Th17/IL-17 axis. Although IL-17A targeted biologics achieve robust clinical efficacy, how cytokine...
Henoch-Schoenlein purpura (HSP) like lesions in IL12RB1 and IL12B defects - A multi-centric experience from India [0.03%]
印度多中心经验：IL12RB1和IL12B缺陷的亨诺赫-舒恩莱因紫癜（HSP）样皮损
Yamini Sharma,Pallavi Nadig,Jhumki Das et al.
Yamini Sharma et al.
Introduction: Mendelian Susceptibility to Mycobacterial Disease (MSMD), caused by IL12RB1 or IL12B mutations, typically presents with intra-cellular infections such as BCG-adenitis or Salmonella. Rarely, patients with IL1...