Uncovering metabolic pathways in human alveolar macrophages in response to lipopolysaccharide [0.03%]
人肺泡巨噬细胞对脂多糖反应的代谢途径研究
Christine C A van Linge,Erik H A Michels,Liza Pereverzeva et al.
Christine C A van Linge et al.
Introduction: Alveolar macrophages (AMs) play an essential role in maintaining homeostasis in the lung and in innate immunity for host defense. To fuel inflammatory responses, AMs do not rely on glycolysis, but require ox...
Susanne Schiffmann,Marina Henke,Friedemann Weber et al.
Susanne Schiffmann et al.
Spindlin-1, a multivalent epigenetic reader, is a new target for cancer therapy. Beside the anticancer effect, modulation of the recognition of methyl marks of histones may impact the immune system, which plays an important role in the anti...
Dendritic cell dysfunction, including impaired IL-12 production, is associated with chronic pulmonary aspergillosis [0.03%]
树突细胞功能障碍（包括IL-12产生受损）与慢性肺曲霉病相关联
Stefano A P Colombo,Sara Gago,Mathilde Chamula et al.
Stefano A P Colombo et al.
Background: Growing evidence links immune dysfunction, notably impaired IFNγ production, to chronic pulmonary aspergillosis (CPA), but understanding of the immune phenotype in CPA patients remains limited. ...
Correction to: Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice [0.03%]
Correction to: IRF4在糖尿病易感NOD小鼠自身免疫反应中的调节作用
Published Erratum
Clinical and experimental immunology. 2025 Jan 21;219(1):uxaf032. DOI:10.1093/cei/uxaf032 2025
Complement factors as biomarkers in ANCA-associated vasculitis in remission [0.03%]
补体因子在ANCA相关性血管炎缓解期中的生物标志物作用
Rebecca Trattner,Maria Iordanou,Sophie Ohlsson et al.
Rebecca Trattner et al.
Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a...
The Pathophysiology of Hemophagocytic lympho-histiocytosis (HLH) syndrome and insights from animal models [0.03%]
噬血细胞综合征（HLH）的病理生理及动物模型研究进展
Sayan Mukherjee,Puneet Kumar
Sayan Mukherjee
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome characterized by an aberrant immune response against host tissues. It can arise from diverse triggers like infection, inflammation, malignancy, genetic defects,...
Engaging PD-1 rescues regulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis [0.03%]
PD-1的激活可增强调节性T细胞功能并抑制炎症T细胞在类风湿关节炎中的作用
Kaustav Chowdhury,Uma Kumar,Jaydeep Chaudhuri et al.
Kaustav Chowdhury et al.
Background: Despite their synovial enrichment Regulatory T cells (Treg) fail to alleviate the joint inflammation in rheumatoid arthritis (RA). This indicates their functional impairment in the synovial milieu of RA patien...
Eleanor Karp-Tatham,Julian C Knight,Alexandre Bolze
Eleanor Karp-Tatham
The human response to vaccination exhibits considerable variability due to a complex interplay of heritable and environmental factors. This review examines the current understanding of the role of human genetics in vaccine responses, encomp...
Chronic Granulomatous disease: Lessons in Cell Biology From Monogenic Immunodeficiency [0.03%]
慢性肉芽肿病：单基因免疫缺陷的细胞生物学启示
Paige M Mortimer,Shuli Svetitsky,David C Thomas
Paige M Mortimer
Reactive oxygen species (ROS) are produced in immune cells by the phagocyte NADPH oxidase (NOX2) system that carries out coordinated transfer of electrons to molecular oxygen. The importance of the system in host defence and immunoregulatio...
1-methyl-tryptophan improves anxiety-like behavior in colitis mice by inhibiting neuroinflammation, promoting cell regeneration and decreasing apoptosis [0.03%]
1-甲基色氨酸通过抑制神经炎症、促进细胞再生和减少凋亡来改善结肠炎小鼠的类似焦虑行为
Li-Ping Zhao,Lu-Lu Tan,Yi-Meng Xia et al.
Li-Ping Zhao et al.
Introduction: Mood disorders such as anxiety are important extra-intestinal manifestations of inflammatory bowel disease (IBD), and are more prevalent in active IBD. Studies have shown that pharmacologically-induced anxie...