LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling [0.03%]
线性泛素化调节因子LUBAC在线性泛素化中的作用及其对免疫信号的调控功能研究进展
Kazuhiro Iwai
Kazuhiro Iwai
Ubiquitination is a reversible post-translational modification in which ubiquitin chains are conjugated to target proteins to modulate protein function. The type of ubiquitin chain determines the mode of protein regulation. It has been show...
Akihide Fujisawa
Akihide Fujisawa
Understandings of turbulent plasma have been developed along with nuclear fusion research for more than a half century. Long international research has produced discoveries concerning turbulent plasma that allow us to notice the hidden natu...
JF1/B6F1 Ngly1-/- mouse as an isogenic animal model of NGLY1 deficiency [0.03%]
NGLY1缺陷的小鼠近交系JF1/B6F1-Ngly1-/-作为异基因动物模型
Makoto Asahina,Reiko Fujinawa,Haruhiko Fujihira et al.
Makoto Asahina et al.
N-Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1-/- mice with a C57BL/6 (B6) background are embryonically lethal, studies on the mechanism of NGLY1 deficiency using mice...
Ken-Ichi Uchida
Ken-Ichi Uchida
The interconversion between spin, charge, and heat currents is being actively studied from the viewpoints of both fundamental physics and thermoelectric applications in the field of spin caloritronics. This field is a branch of spintronics,...
Insight into chemical mechanisms of sepal color development and variation in hydrangea [0.03%]
探究扶桑花萼颜色发育和变异的化学机制
Kumi Yoshida,Kin-Ichi Oyama,Tadao Kondo
Kumi Yoshida
Hydrangea (Hydrangea macrophylla) is a unique flower because it is composed of sepals rather than true petals that have the ability to change color. In the early 20th century, it was known that soil acidity and Al3+ content could intensify ...
On the effectiveness of the search and find method to suppress spread of SARS-CoV-2 [0.03%]
关于搜索和查找方法抑制SARS-CoV-2传播有效性的研究
Hirotaka Sugawara
Hirotaka Sugawara
Search and find methods*) such as cluster tracing1)-6) or large-scale PCR testing**) of those who exhibit no symptoms or only mild symptoms of COVID-19 is shown by data analysis to be a powerful means to suppress the spread of COVID-19 inst...
Tomoyuki Miyazaki,Hiroki Abe,Hiroyuki Uchida et al.
Tomoyuki Miyazaki et al.
Psychiatric and neurological disorders severely hamper patient's quality of life. Despite their high unmet needs, the development of diagnostics and therapeutics has only made slow progress. This is due to limited evidence on the biological...
Yasunori Yamazaki
Yasunori Yamazaki
The field of cold antimatter physics has rapidly developed in the last 20 years, overlapping with the period of the Antiproton Decelerator (AD) at CERN. The central subjects are CPT symmetry tests and Weak Equivalence Principle (WEP) tests....
Bacterial γ-glutamyltranspeptidases, physiological function, structure, catalytic mechanism and application [0.03%]
细菌γ-谷氨酰胺转肽酶的生理功能、结构、催化机制及应用
Hideyuki Suzuki,Keiichi Fukuyama,Hidehiko Kumagai
Hideyuki Suzuki
γ-Glutamyltranspeptidase (GGT) has been widely used as a marker enzyme of hepatic and biliary diseases and relations between various diseases and its activity have been studied extensively. Nevertheless, several of its fundamental enzymati...
Fumiyo Ikeda
Fumiyo Ikeda
Ubiquitin is a small protein used for posttranslational modification and it regulates every aspect of biological functions. Through a three-step cascade of enzymatic action, ubiquitin is conjugated to a substrate. Because ubiquitin itself c...