JF1/B6F1 Ngly1-/- mouse as an isogenic animal model of NGLY1 deficiency
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N-Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1-/- mice with a C57BL/6 (B6) background are embryonically lethal, studies on the mechanism of NGLY1 deficiency using mice have been problemat... ...