Shun-Ichi Sekine
Shun-Ichi Sekine
Transcription is an essential biological process that underlies all cellular and organismal activities. In eukaryotes, RNA polymerase II (RNAPII) transcribes every protein-coding gene and many non-coding genes, playing a central role in gen...
Shigeru Chiba
Shigeru Chiba
The term "clone" is commonly used in the medical and life sciences to denote a genetically identical population, at both the individual and cellular levels. The concept of clonal expansion is of fundamental importance in cancer research. Th...
Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system [0.03%]
个体运动功能的分子基础：肌肉骨骼系统发育和稳态中基因表达调控的综合理解
Hiroshi Asahara
Hiroshi Asahara
This review examines the molecular mechanisms controlling the development and homeostasis of the musculoskeletal system through gene expression regulation. It introduces key discoveries from basic transcriptional control to advanced mechano...
Syntheses and biological evaluation of M-COPA analogs derived from pentadienoic Weinreb amide [0.03%]
基于戊二烯诺瑞伯胺的M-COPA类似物的合成及其生物活性评价
Hisazumi Tsutsui,Daiki Usukura,Fumiya Watabe et al.
Hisazumi Tsutsui et al.
M-COPA (1), which contains diene and 3-picolylamine moieties in its side chain and seven stereogenic centers in a multisubstituted octalin skeleton, strongly inhibits the growth of several cancer cell lines. Expecting the improvement of con...
A novel glomerulopathy model demonstrates renal counterbalance via local angiotensin II regulation [0.03%]
一个新的系膜增生性肾小球病模型显示了局部血管紧张素Ⅱ调节的肾脏自稳态机制
Kazuo Sakamoto,Kunio Kawanishi,Jun-Dal Kim et al.
Kazuo Sakamoto et al.
Renal counterbalance, involving compensatory hypertrophy of the healthy kidney and atrophy of the injured one, remains incompletely understood, particularly at the glomerular level. In this study, we employed NEP25 mice, which selectively e...
Correction to "Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of Cyanidioschyzon merolae" [0.03%]
有关"Cyanidioschyzon merolae细胞周期中全局GTP水平变化与核苷二磷酸激酶蛋白DYNAMO2的动力学相关性"一文的更正
Yuuta Imoto,Yuichi Abe,Kanji Okumoto et al.
Yuuta Imoto et al.
New molecules indispensable for hyaluronan degradation, HYBID (CEMIP/KIAA1199) and TMEM2 (CEMIP2): Differential roles in physiological and pathological non-neoplastic conditions [0.03%]
新的降解透明质酸的分子HYBID（CEMIP/KIAA1199）和TMEM2（CEMIP2）：在生理和病理非肿瘤条件下发挥的不同作用
Hiroyuki Yoshida,Shintaro Inoue,Yasunori Okada
Hiroyuki Yoshida
The biological activity of hyaluronan (HA), a major component of the extracellular matrix in vertebrate tissues, depends on its molecular weight, and thus its degradation is a critical process for HA biological functions. Here, we review th...
Munetaka Akita
Munetaka Akita
Photoredox catalysis, which facilitates organic transformations under visible-light irradiation, including sunlight, has garnered considerable attention as a cornerstone of green chemistry. Since the early days of this field around 2010, th...
Pursuing the identity of a natural medicine licorice by Dr. Shoji Shibata that he firstly investigated half a century before [0.03%]
追寻半世纪前藤田昌一是首位调查的天然药物甘草的身份
Michiho Ito
Michiho Ito
This article is an explanatory review on a study of licorice stored in Shosoin Repository reported in this journal by Dr. Shoji Shibata in 2003 (Proc. Jpn. Acad. Ser. B 79, 176-180). The study using new technologies at that time for identif...
The shifting paradigm of chromatin structure: from the 30-nm chromatin fiber to liquid-like organization [0.03%]
染色质结构的转变观念：从30纳米纤维到类似液体的组织模式
Kazuhiro Maeshima
Kazuhiro Maeshima
The organization and dynamics of chromatin are critical for genome functions such as transcription and DNA replication/repair. Historically, chromatin was assumed to fold into the 30-nm fiber and progressively arrange into larger helical st...