Impact of age and histological type on programmed death-ligand 1 expression in non-small cell lung cancer - a single-center analysis of 1,606 cases [0.03%]
年龄和组织学类型对非小细胞肺癌程序性死亡配体1表达的影响——一项单中心1606例分析
Anna Szumera-Ciećkiewicz,Piotr Wiśniewski,Agnieszka Tomczyk-Szatkowska et al.
Anna Szumera-Ciećkiewicz et al.
Programmed death-ligand 1 (PD-L1) guides immune checkpoint inhibitor use in non-small cell lung cancer (NSCLC), yet its variation by age and histology remains uncertain. We retrospectively evaluated 1,606 consecutive NSCLC cases (2017-2022)...
Beata Sikorska,Radzisław Kordek
Beata Sikorska
Gabriele Gaggero,Silvia Bozzano,Nicoletta Fasano et al.
Gabriele Gaggero et al.
This case report describes a rare and challenging glioblastoma variant with a bi-phasic morphology comprising both giant cell and primitive neuronal components. The tumour exhibited aggressive features and was difficult to diagnose during t...
Aleksandar Krbanjevi,Tibor Valyi-Nagy
Aleksandar Krbanjevi
We present a case involving a 70-year-old Latina woman who experienced a sud-den onset of lightheadedness, diplopia, vertigo, and loss of balance. Imaging studies revealed a right thalamic intracerebral haemorrhage that obstructed the velum...
Multifocal cutaneous leishmaniasis in a patient treated with golimumab for psoriaticarthritis [0.03%]
戈利木单抗治疗银屑病关节炎患者的多灶性皮肤利什曼热病
Veronica Forte,Anna Silvia Biamonte,Massimo Menichini et al.
Veronica Forte et al.
Leishmaniasis is a zoonosis caused by protozoans transmitted by sandflies. Immu-nosuppression is a risk factor for developing leishmaniasis in patients treated with TNF inhibitors for autoimmune diseases. A 65-year-old man with a 14-year hi...
Better pathology education during undergraduate education: Clinical dentists' expectations [0.03%]
本科生教育中更好的病理学教育：临床牙医的期望
Songül Sahin
Songül Sahin
The education curriculum of the faculty of dentistry includes both general pathol-ogy and oral pathology courses. In our planned study, we aimed to determine the needs of dentists who graduated from the faculty of dentistry and received spe...
High mobility group box 1 attenuates aortic stenosis by modulating macrophages to reduce valvular calcification [0.03%]
高迁移率族蛋白B1通过调节巨噬细胞减少瓣膜钙化来缓解主动脉狭窄
Dong Zhao,Yun Zhao,Li-Na Luan
Dong Zhao
Our previous study demonstrated that HMGB1 may suppress M1 macrophage polarisation and mitigate the progression of calcific aortic valve disease (CAVD). However, the role of HMGB1 in regulating macrophage-mediated valvular calcifi-cation re...
miR-21 regulates LPS-induced apoptosis and inflammatory injury in rat cardiomyocytes by targeting PLD1 and STAT3 [0.03%]
miR-21通过靶向PLD1和STAT3调控脂多糖诱导的大鼠心肌细胞凋亡及炎症损伤
Rui Chen,Wei Xiong,Ruiying Liu et al.
Rui Chen et al.
This study aims to elucidate the role and molecular mechanism of microRNA-21 (miR-21) in LPS-induced inflammatory injury in H9c2 cardiomyocytes. H9c2 cardiomyocytes were treated with lipopolysaccharide (LPS) to establish an in vitro model. ...
Histopathological image analysis and enhanced diagnostic accuracy explainability for oral cancer detection [0.03%]
用于口腔癌检测的组织病理图像分析和增强诊断准确性解释能力
V P Gladis Pushparathi,Sylaja Vallee NarayanS R,Pratheeba R S et al.
V P Gladis Pushparathi et al.
Deep learning (DL) has transformed medical imaging, particularly in the realm of oral cancer (OC) diagnosis using histopathological images. Timely detection of OC is es-sential for enhancing precision medicine and saving lives. However, inc...
Identification of metabolism regulators as diagnostic markers for ulcerative colitis and their correlation with immune infiltration [0.03%]
溃疡性结肠炎代谢调节因子的鉴定及其与免疫浸润的相关性研究
Qilong Duan,Peng Liu,Hualei Chen et al.
Qilong Duan et al.
This study determined novel metabolism-related diagnostic biomarkers for ulcer-ative colitis (UC) and assessed their correlation with immune cell infiltration levels. Transcriptome data of UC was downloaded from the Gene Expression Omnibus ...