Pathologic assessment of response to neoadjuvant therapy in melanoma - recommendations for the evaluation of post-resection specimens [0.03%]
黑色素瘤新辅助治疗的病理反应评估及术后标本检测建议
Michał Wągrodzki,Irmina Maria Michalek,Monika Durzynska et al.
Michał Wągrodzki et al.
The hidden tumour: giant anterior mediastinal thymolipoma, an incidental finding [0.03%]
偶然发现的巨大前纵隔胸腺类脂瘤（隐藏肿瘤）
Banyameen Iqbal,Mangesh Machindra Londhe,Sushama Gurwale et al.
Banyameen Iqbal et al.
Thymolipoma is an uncommon, non-malignant mediastinal mass characterized by a mixture of mature fat and normal thymic tissue. It typically grows slowly and is often asymptomatic until it reaches a large size, causing compressive symptoms. W...
Atypical lymph node involvement in a rare case of Kikuchi-Fujimoto disease: a case report and literature review [0.03%]
非典型淋巴结累及的罕见Kikuchi-Fujimoto病病例报告及文献复习
Jakub Stanek,Jagoda Jakubik-Stanek,Dominik Paprocki et al.
Jakub Stanek et al.
Kikuchi-Fujimoto disease (KFD) is a rare, benign condition that often mimics infectious or malignant disorders. We report the case of a 36-year-old woman with atypical lymphadenopathy involving axillary, supraclavicular, and infraclavicular...
Prognostic impact of tumour budding, stromal phenotype, and CD163-positive macrophages in intestinal-type gastric adenocarcinoma [0.03%]
肿瘤芽生、间质表型和CD163阳性巨噬细胞在肠型胃腺癌中的预后价值
Elif Aydın,Ömer Atmış,Hanife Seda Mavili et al.
Elif Aydın et al.
The tumour microenvironment plays an important role in the progression of gastric adenocarcinoma, but the prognostic value of its histopathological and immunological components in intestinal-type tumours remains unclear. This retrospective ...
Pumilio2, but not Pumilio1, expression is significantly increased in high-grade and metastatic gastroenteropancreatic neuroendocrine neoplasms [0.03%]
高分级和转移性胃肠道胰腺神经内分泌肿瘤中Pumilio2而非Pumilio1的表达明显增加
Patryk Kraiński,Andrzej Kluk,Jan Gruszczynski et al.
Patryk Kraiński et al.
Pumilio proteins (PUM1 and PUM2) are evolutionarily conserved RNA-binding proteins that regulate gene expression at the post-transcriptional level and have been implicated in tumourigenesis in various cancers. However, their role in gastroe...
The clinicopathological significance of METTL3/SERPINE2 immunoexpression in urothelial carcinoma of the urinary bladder [0.03%]
METTL3/SERPINE2免疫表达对尿路上皮癌的临床病理意义
Mina Ezzat Attya,Hany Yousry Sayed
Mina Ezzat Attya
The aim of this study was to investigate the immunohistochemical expression of METTL3 and SERPINE2 in urothelial carcinoma and to assess their individual and combined associations with clinicopathological features and possible correlation. ...
Correlation of programmed death cell ligand-1 expression in non-small cell lung cancer between small biopsy and surgical specimens [0.03%]
小标本与手术标本PD-L1检测在非小细胞肺癌中的相关性分析
Jelena Aleksić,Dragana Tegeltija,Ivan Aleksić et al.
Jelena Aleksić et al.
Immunotherapy with programmed death cell ligand-1 (PD-L1) antibodies is an essential treatment for non-small cell lung cancer (NSCLC), and immunohistochemical assessment of PD-L1 expression is required for therapeutic stratification. This s...
Single-step next-generation sequencing of immunoglobulin heavy chain genes to detect clonality in classical Hodgkin lymphoma [0.03%]
单次测序免疫球蛋白基因检测经典霍奇金淋巴瘤克隆性
Mohsen Navari,Gazzola Anna,Claudia Mannu et al.
Mohsen Navari et al.
Classical Hodgkin lymphoma (cHL) diagnosis occasionally requires clonality assessment. However, the paucity of neoplastic Hodgkin and Reed-Sternberg cells among abundant reactive elements dramatically reduces the sensitivity of standard pol...
Suppressing Dicer inhibits proliferation and contributes to cellular senescence, partially via a p21-associated senescence pathway [0.03%]
Dicer抑制可抑制增殖并促进细胞衰老，部分通过与p21相关的衰老途径实现
Chao-Wen Cheng,Wen-Fang Fang,Yea-Mey Yang et al.
Chao-Wen Cheng et al.
Dicer is known to engage in regulating micro (mi)RNA biosynthesis. However, the role in driving thyroid carcinogenesis is unknown. In this study, we explored the role of Dicer in the carcinogenesis of well-differentiated thyroid carcinoma (...
Prognostic significance of hypoxia-induced autophagy related markers in malignant surface epithelial ovarian tumours [0.03%]
卵巢恶性上皮性肿瘤中低氧诱导的自噬相关标志物的预后意义
Alaa Ibrahim Mohamed Amer,Sara A Darwish,Nehal Heabah
Alaa Ibrahim Mohamed Amer
Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a pro-apoptotic protein, regulates autophagy. BNIP3 is induced in hypoxic cells, being regulated by hypoxia-inducible factor 1-α (HIF1-α). The role of hypoxia-induced autophagy in...