Circulating Cytokines and Nitric Oxide are Involved in the Inhibition of Neutrophil Migration in Patients with Uterine Cervical Neoplasia [0.03%]
与宫颈肿瘤患者中性粒细胞迁移抑制有关的细胞因子和一氧化氮的研究
Douglas Côbo Micheli,Paulo Cesar Fernandes Jr,João Celso Garcia Cruvinel et al.
Douglas Côbo Micheli et al.
Aim: To verify if patients with cervical neoplasia produce mediators that reduce leukocyte function. Methods: Control neutrophils incub...
Prathima Prodduturi,Philip J Bierman
Prathima Prodduturi
Primary central nervous system lymphoma (PCNSL) constitutes a rare group of extranodal non-Hodgkin's lymphoma (NHL) primarily of B cell origin. It occurs in both immuno-competent and immune-compromised patients. High dose m ethotrexate (HD-...
Tara L Lin,M Yair Levy
Tara L Lin
Acute myeloid leukemia (AML) is a heterogeneous disease with variable clinical outcomes. Cytogenetic analysis reveals which patients may have favorable risk disease, but 5-year survival in this category is only approximately 60%, with inter...
Small cell lung cancer doubling time and its effect on clinical presentation: a concise review [0.03%]
小细胞肺癌倍增时间及其对临床表现的影响：简要综述
Kassem Harris,Inga Khachaturova,Basem Azab et al.
Kassem Harris et al.
Small cell lung cancer (SCLC) is one of many types rapidly growing malignant diseases, such as Burkitt's lymphoma and testicular germ cell cancers. At present, there is no reliable way to screen for SCLC, and imaging modalities tend to be d...
Claudio Casella,Vincenzo Villanacci,Filippo D&#x;Adda et al.
Claudio Casella et al.
Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. More rarely neoplasms with histology and immunohistochemistry similar to GISTs may occur outside...
Relapsed and/or Refractory Mantle Cell Lymphoma: What Role for Temsirolimus? [0.03%]
替西罗莫司在复发和/或难治性套细胞淋巴瘤中的作用是什么？
Sebastian Kirschey,Susanne Wagner,Georg Hess
Sebastian Kirschey
Mantle Cell Lymphoma (MCL) is associated with a dismal prognosis. Recently, along with the improved understanding of the pathophysiology of this disease, new first line regimens have been established and in addition novel treatment options ...
Development of myelodysplastic syndrome and acute myeloid leukemia 15 years after hydroxyurea use in a patient with sickle cell anemia [0.03%]
一例镰状细胞贫血患者使用羟基脲治疗后15年发生骨髓增生异常综合征和急性髓系白血病的发展案例
Walid Baz,Vesna Najfeld,Matthew Yotsuya et al.
Walid Baz et al.
We report a 41 year old male with sickle cell disease who developed a myelodysplastic syndrome and acute myeloid leukemia with complex karyotype involving chromosomes 5, 7 and 17 after 15 years of hydroxyurea treatment. He responded poorly ...
The Evolving Role of Maintenance Therapy Using Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) in the Management of Advanced Non-Small-Cell Lung Cancer [0.03%]
表皮生长因子受体酪氨酸激酶抑制剂维持治疗在晚期非小细胞肺癌中的作用及其演变
Chao H Huang,Benjamin C Powers
Chao H Huang
The epidermal growth factor receptor (EGFR) plays an important role in the development of many cancers, including non-small cell lung cancer. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are a class of novel biolo...
Trastuzumab for HER2-Positive Metastatic Breast Cancer: Clinical and Economic Considerations [0.03%]
HER2阳性转移性乳腺癌曲妥珠单抗临床和经济因素考虑
Alwin Jeyakumar,Tallal Younis
Alwin Jeyakumar
Trastuzumab is a recombinant humanized monoclonal antibody that selectively targets the extra-cellular domain of the HER2 receptor. It was approved by the FDA in September 1998 as the first targeted therapy for HER2-positive metastatic brea...
State-of-the-Art Management of Patients Suffering from Chronic Lymphocytic Leukemia [0.03%]
慢性淋巴细胞白血病患者的治疗进展
Ruth Clifford,Anna Schuh
Ruth Clifford
The management of chronic lymphocytic leukemia (CLL) has evolved dramatically in the last decade. For the first time, clinical intervention has been shown to alter the natural history of the disease. Considerable efforts are focussing on be...