Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials [0.03%]
泊西氟沙星眼用悬浮液治疗儿童及青少年细菌性结膜炎的疗效和安全性：3项随机双盲安慰剂对照多中心临床试验的事后亚组分析
Timothy L Comstock,Michael R Paterno,Dale W Usner et al.
Timothy L Comstock et al.
Background: Acute conjunctivitis is the most frequent eye disorder seen by primary care physicians and one that often affects children. Besifloxacin is a new topical fluoroquinolone, the first chlorofluoroquinolone, for t...
Comparative Study
Paediatric drugs. 2010 Apr 1;12(2):105-12. DOI:10.2165/11534380-000000000-00000 2010
Published pediatric randomized drug trials in developing countries, 1996-2002 [0.03%]
1996-2002年发展中国家发表的儿科随机药物试验
Khairun N B Nor Aripin,Helen M Sammons,Imti Choonara
Khairun N B Nor Aripin
Background: The greatest burden of disease in children lies in the developing world; however, previous reviews have suggested that few randomized controlled trials (RCTs) involving children take place in developing countr...
Jennifer Freed,Kara M Kelly
Jennifer Freed
Hodgkin lymphoma is one of the few cancers that affect both adults and children. Cure rates for Hodgkin lymphoma remain among the best for pediatric cancers. However, cure is often associated with significant delayed effects of therapy, inc...
Epidemiology and management of insomnia in children with autistic spectrum disorders [0.03%]
自闭症儿童失眠的流行病学和治疗
Silvia Miano,Raffaele Ferri
Silvia Miano
Insomnia is the predominant sleep concern in children with autistic spectrum disorder (ASD), and its nature is most likely multifactorial, with neurochemical (abnormalities in serotonergic transmission or melatonin levels), psychiatric (anx...
Long-term neurodevelopment of children exposed in utero to ciclosporin after maternal renal transplant [0.03%]
肾移植后孕妇在妊娠期接触环孢素的儿童长期神经发育研究
Irena Nulman,Michael Sgro,Maru Barrera et al.
Irena Nulman et al.
Background: Immunosuppressant therapy is essential in the prevention of organ transplant rejection. Objective: To evaluate the long-ter...
Natalie J Carter,Gillian M Keating
Natalie J Carter
Bosentan is a dual endothelin-1 (ET-1) receptor antagonist that has affinity for ET-1 receptors A and B. In the EU, oral bosentan (Tracleer) is indicated to improve exercise capacity and symptoms in patients with pulmonary arterial hyperten...
Optimizing emetic control in children receiving antineoplastic therapy: beyond the guidelines [0.03%]
儿童抗肿瘤治疗的止吐优化策略——指南之外的经验
L Lee Dupuis,Paul C Nathan
L Lee Dupuis
Existing guidelines for the prevention of antineoplastic chemotherapy-induced nausea and vomiting (CINV) in children are constrained by the lack of robust evidence. Current guidelines recommend the use of a serotonin 5-HT(3) receptor antago...
Adverse effects of immunosuppression in pediatric solid organ transplantation [0.03%]
儿童实体器官移植免疫抑制不良反应
Kristine S Schonder,George V Mazariegos,Robert J Weber
Kristine S Schonder
Solid organ transplantation is a life-saving treatment for end-stage organ failure in children. Immunosuppressant medications are used to prevent rejection of the organ transplant. However, these medications are associated with significant ...
Juvenile-onset clinically amyopathic dermatomyositis: an overview of recent progress in diagnosis and management [0.03%]
青少年皮肌炎的诊断与治疗近况综述（无肌肉病变）
Hobart W Walling,Pedram Gerami,Richard D Sontheimer
Hobart W Walling
Juvenile-onset amyopathic dermatomyositis is an uncommon variant of juvenile-onset dermatomyositis (JDM), characterized by the hallmark cutaneous features of dermatomyositis for at least 6 months without clinical or laboratory evidence of m...
Juvenile myelomonocytic leukemia: epidemiology, etiopathogenesis, diagnosis, and management considerations [0.03%]
关于幼年型粒单核细胞白血病的流行病学、发病机制、诊断及治疗要点综述
Ayami Yoshimi,Seiji Kojima,Naoto Hirano
Ayami Yoshimi
Juvenile myelomonocytic leukemia (JMML) is a rare hematopoietic malignancy of early childhood with features characteristic of both myelodysplastic and myeloproliferative disorders. Recent studies clearly show that the deregulated activation...