Sheridan M Hoy
Sheridan M Hoy
Ocrelizumab, a recombinant humanized IgG1 monoclonal antibody directed against CD20-expressing B-cells, has been developed by Genentech, Inc. for the treatment of multiple sclerosis (MS). Both intravenous infusion and subcutaneous injection...
21‑Valent Pneumococcal Conjugate Vaccine V116 (CAPVAXIVE®): Pediatric First Approval [0.03%]
二十一价肺炎球菌结合疫苗V116(CAPVAXIVE®)：儿科用药首次批准
Matt Shirley
Matt Shirley
The 21‑valent pneumococcal conjugate vaccine (PCV) V116 (CAPVAXIVE®), developed by Merck & Co., has been approved in the USA since June 2024 for active immunization for the prevention of pneumonia and invasive disease caused by Streptococ...
Effectiveness and Safety of IL-17A Inhibitors in Pediatric Psoriasis: A Real-World, Multicenter, International Study [0.03%]
一项真实世界、多中心国际研究：白介素17A抑制剂治疗儿科银屑病的有效性和安全性
Vito Di Lernia,Bertille Bonniaud,Eve Puzenat et al.
Vito Di Lernia et al.
Background: Secukinumab and ixekizumab are interleukin (IL)-17A inhibitors approved for the treatment of moderate-to-severe plaque psoriasis in children and adolescents. While their efficacy has been established in clinic...
Incorporating Immunotherapies into the Evolving Standard of Care for Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia [0.03%]
将免疫疗法融入儿童B细胞前体急性淋巴细胞白血病治疗的标准化疗方案中
Andrej Lissat,Erica Brivio,Janine Stutterheim et al.
Andrej Lissat et al.
Survival for pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) exceeds 90% in high-income countries due to risk-adapted chemotherapy and measurable residual disease (MRD)-guided strategies. However, relapse remains a leading...
Safety and Efficacy of Oral Ferric Maltol and Ferrous Sulfate for Iron Deficiency Anemia in Infants, Children and Adolescents: A Multicenter Randomized Trial [0.03%]
口服马来糖铁和硫酸亚铁治疗婴幼儿、儿童及青少年缺铁性贫血安全性和有效性的多中心随机试验
David Gass,Andrew Freiberg,Marcus K H Auth et al.
David Gass et al.
Objectives: This phase 3, multicenter, randomized, open-label study (NCT05126901) compared oral ferric maltol with ferrous sulfate, across 23 sites in the US and the UK, evaluating the safety, efficacy, pharmacokinetics, ...
Safety and Effectiveness of Pain Medications for Migraine Management During Pregnancy and Lactation [0.03%]
孕期和哺乳期偏头痛的镇痛药物安全性和有效性研究
Liza Smirnoff,Nicolas Garzon Mancera,Tayina Hyppolite et al.
Liza Smirnoff et al.
The management of migraine during pregnancy and lactation poses a major challenge owing to the paucity of safety data. While very little safety data are available for new targeted migraine therapies such as calcitonin gene receptor protein ...
Recent Advances in the Pharmacological Management of Pediatric Spondyloarthritis [0.03%]
儿科脊柱关节炎药物治疗的新进展
Umit Gul,Elif Kilic Konte,Mehmet Yildiz et al.
Umit Gul et al.
Juvenile spondyloarthritis (JSpA) refers to a heterogeneous group of inflammatory diseases affecting peripheral joints and the axial skeleton during childhood and adolescence. Enthesitis-related arthritis (ERA) and juvenile psoriatic arthri...
Molluscum Contagiosum Treatments in Children: A Systematic Review with Network Meta-Analysis [0.03%]
儿童传染性软疣的治疗方法：系统评价与网络 meta 分析
Letícia Rocha Campos,Gisella Chiara Carpi,Ana Beatriz Nardelli da Silva et al.
Letícia Rocha Campos et al.
Background/objectives: Molluscum contagiosum affects up to 11.5% of children, yet optimal treatment remains uncertain. Previous systematic reviews included mixed adult/pediatric populations, limiting applicability to chil...
Real-World Systemic Treatment Patterns and Outcomes of Children With Severe Alopecia Areata: A French Nationwide Study (ESTAPED ohort) [0.03%]
法国全国性儿童重度斑秃系统治疗模式和结局研究（ESTAPED队列）
Ninon Le Goaziou,Christine Bodemer,Christine Labrèze et al.
Ninon Le Goaziou et al.
Background/objective: Severe forms of alopecia areata (AA) often require off-label systemic treatments (ST) for which data on effectiveness and safety are limited. This study aimed to provide a comprehensive real-world ov...
Epinephrine Underuse for Anaphylaxis in Infants and Toddlers: A Practical Review for Pediatricians [0.03%]
儿科医生对婴幼儿过敏性休克肾上腺素使用不足的原因及对策综述
Stephanie Leeds,Aikaterini Anagnostou,Michael Pistiner et al.
Stephanie Leeds et al.
A recent consensus report defined anaphylaxis as a serious allergic reaction that may involve the skin/mucosa, respiratory, cardiovascular, and/or gastrointestinal systems that can progress rapidly and may cause death. Epinephrine treatment...