Nuria González-Llorens,Daphne Yau,María Clemente León et al.
Nuria González-Llorens et al.
Congenital hyperinsulinism (CHI) is a rare disorder causing persistent hypoglycaemia in infants due to excessive insulin secretion from pancreatic β-cells. It has genetic causes, primarily mutations in ATP-sensitive potassium channel genes...
Dosing and Discontinuation of Methylphenidate Medication in Relation to Weight Status in Children and Adolescents [0.03%]
利他林的用药与停药与儿童和青少年的体重状况的关系
Julia Izsak,Elin E Kimland,Jari Martikainen et al.
Julia Izsak et al.
Background and objective: Evidence and clinical guidelines on methylphenidate dosing in different weight status groups are limited. This study aimed to evaluate real-world methylphenidate dosing practices and treatment di...
Adolescents' and Young Adults' Adherence to Medication During the Transition to Adult Healthcare: A Developmentally Appropriate Framework for Optimising Adherence-Promoting Interventions [0.03%]
青少年和年轻人在转向成人医疗保健期间坚持药物治疗的框架：优化促进依从性干预措施的发展适当性框架
Albert Farre,Lauren Huckerby,Nicola J Gray et al.
Albert Farre et al.
For adolescents and young adults (AYA) with any health condition, it is important that they learn to manage their condition and healthcare as they transition into adulthood. For AYA with childhood-onset long-term conditions, this is also fu...
Extrapolating Guselkumab Efficacy to Juvenile Psoriatic Arthritis from Adult Psoriatic Arthritis and Adult and Pediatric Psoriasis Data [0.03%]
从成人银屑病关节炎和成人及儿科银屑病数据外推Guselkumab疗效至幼年性银屑病关节炎
Herta Crauwels,Sarah Ringold,Samantha Howard et al.
Herta Crauwels et al.
Background: Psoriatic arthritis (PsA) and juvenile PsA (jPsA) are chronic inflammatory diseases with similar features that differ by age and sequence of symptom onset. PsA and psoriasis (PsO) share comparable pathology ac...
Medulloblastoma: Current Standard of Care and Future Treatment Opportunities [0.03%]
髓母细胞瘤的治疗现状和未来展望
Lisa Mayr,Amedeo A Azizi,Johannes Gojo et al.
Lisa Mayr et al.
Medulloblastoma, the most common malignant brain tumor of childhood, is an aggressive embryonal tumor that arises from the posterior fossa. On the molecular level, four clinically relevant subgroups have been established, which have already...
Impact of the Time to Initiation of Indomethacin or Ibuprofen on Patent Ductus Arteriosus Closure Rates [0.03%]
早期应用吲哚美辛或布洛芬对动脉导管未闭关闭率的影响
Brooke Szachnowicz,Julie Nogee,Kartikeya Makker et al.
Brooke Szachnowicz et al.
Objective: Our objective was to describe the clinical impact of time to initiation of indomethacin or ibuprofen on patent ductus arteriosus (PDA) closure rates in preterm neonates. ...
Vedolizumab Versus Other Biologics and the Risk of Venous Thromboembolism in Patients with Pediatric-Onset Inflammatory Bowel Diseases: A Target Trial Emulation Study [0.03%]
vedolizumab与其他生物制剂相比在儿童期发作的炎症性肠病患者中静脉血栓栓塞风险的真实世界研究：目标试验模拟研究
Serena Yun-Chen Tsai,Ashwin N Ananthakrishnan,Harland S Winter et al.
Serena Yun-Chen Tsai et al.
Background: Pediatric-onset inflammatory bowel diseases (IBD) are associated with an elevated risk of venous thromboembolism (VTE). However, data on the VTE risk in these patients treated with novel biologics, particularl...
Frank M C Besag,Michael J Vasey,Richard F M Chin
Frank M C Besag
Childhood epilepsies comprise a group of heterogeneous conditions associated with diverse aetiologies, seizure severities/types, comorbidities, degrees of impairment and prognoses. Seizures are refractory to antiseizure medications (ASMs) i...
Hannah A Blair
Hannah A Blair
Fremanezumab (fremanezumab-vfrm; AJOVY®) is a humanized monoclonal antibody developed by Teva Pharmaceuticals to selectively target calcitonin gene-related peptide (a vasodilatory neuropeptide involved in the pathophysiology of migraine). ...
Camila C Luz,Paulo F Collett-Solberg
Camila C Luz
Growth hormone (GH) has been used to treat severe GH deficiency for more than 60 years, with other indications dependent upon approval from national medical societies and governmental agencies. Many changes in GH preparations have been made...