Managing the underlying cause of cystic fibrosis: a future role for potentiators and correctors [0.03%]
管理囊性纤维化症的内在因素：阳离子和纠正剂的未来作用
Luis J V Galietta
Luis J V Galietta
Cystic fibrosis (CF), a severe genetic disease, is caused by mutations that alter the structure and function of CFTR, a plasma membrane channel permeable to chloride and bicarbonate. Defective anion transport in CF irreversibly damages the ...
Combination pharmacotherapy for psychiatric disorders in children and adolescents: prevalence, efficacy, risks and research needs [0.03%]
儿童及青少年精神障碍的联合用药疗法：流行病学、疗效、风险和研究需求
Jon Jureidini,Anne Tonkin,Elsa Jureidini
Jon Jureidini
Polypharmacy, defined as the concomitant use of two or more psychotropic drugs, has become increasingly common in the paediatric and adolescent population over the past two decades. Combining psychotropic drugs leads to possible increases i...
Clinical pharmacology of indomethacin in preterm infants: implications in patent ductus arteriosus closure [0.03%]
吲哚美辛用于早产儿的临床药理学及其对动脉导管未闭的影响
Gian Maria Pacifici
Gian Maria Pacifici
Indomethacin is a non-steroidal anti-inflammatory drug that is a potent inhibitor of prostaglandin E(2) synthesis. After birth, the ductus arteriosus closes spontaneously within 2-4 days in term infants. The major factor closing the ductus ...
Paul D Robinson,Peter Van Asperen
Paul D Robinson
Asthma control remains a significant challenge in the pediatric age range in which ongoing loss of lung function in children with persistent asthma has been reported, despite the use of regular preventer therapy. This has important implicat...
Rejin Kebudi,Fatma Betul Cakir
Rejin Kebudi
The prognosis for children with diffuse intrinsic pontine gliomas (DIPGs) is dismal. Although DIPGs constitute only 10-15 % of all pediatric brain tumors, they are the main cause of death in this group with a median survival of less than 12...
Potential therapies for anaplastic lymphoma kinase-driven tumors in children: progress to date [0.03%]
儿童间变性淋巴瘤激酶驱动型肿瘤的潜在疗法：迄今所取得的进展
Eric J Lowe,Megan S Lim
Eric J Lowe
Anaplastic lymphoma kinase (ALK) is an oncogenic tyrosine kinase that is deregulated due to a variety of molecular mechanisms in pediatric cancer. They include chromosomal translocations, activation mutations, and gene amplifications. Since...
Challenges in the pharmacologic management of obesity and secondary dyslipidemia in children and adolescents [0.03%]
儿童和青少年肥胖及相关继发性血脂异常的药理学管理面临的挑战
Mary Jayne Kennedy,Kevin D Jellerson,Michael Z Snow et al.
Mary Jayne Kennedy et al.
The rise in childhood obesity has lead to an increased number of children with lipid abnormalities and the predominance of a combined dyslipidemic pattern characterized by a moderate-to-severe elevation in triglycerides, normal-to-mild mild...
Medication discrepancies at transitions in pediatrics: a review of the literature [0.03%]
儿科转换期的药物差异：文献综述
Chi Huynh,Ian C K Wong,Stephen Tomlin et al.
Chi Huynh et al.
Medication reconciliation is an important process in reducing medication errors in many countries. Canada, the USA, and UK have incorporated medication reconciliation as a priority area for national patient safety initiatives and goals. The...
A predictive pharmacokinetic/pharmacodynamic model of fentanyl for analgesia/sedation in neonates based on a semi-physiologic approach [0.03%]
基于半生理学方法的新生儿镇痛/镇静用芬太尼预测药动/药效模型
Esther Encinas,Rosario Calvo,John C Lukas et al.
Esther Encinas et al.
Background and objectives: Fentanyl is a synthetic opioid commonly used as an anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage regimens in this population are often empirically deri...
Cost of biologics in the treatment of juvenile idiopathic arthritis: a factor not to be overlooked [0.03%]
生物制剂治疗幼年特发性关节炎的成本：不可忽视的因素
Femke H M Prince,Lisette W A van Suijlekom-Smit
Femke H M Prince
Biologics are a promising treatment option for juvenile idiopathic arthritis (JIA) but drug costs are very high compared to conventional treatment. From a socioeconomic view the additional costs of new interventions should be weighed agains...