Clinical pharmacology of indomethacin in preterm infants: implications in patent ductus arteriosus closure
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Indomethacin is a non-steroidal anti-inflammatory drug that is a potent inhibitor of prostaglandin E(2) synthesis. After birth, the ductus arteriosus closes spontaneously within 2-4 days in term infants. The major factor closing the ductus arteriosus is the te... ...
