Bridging to Paediatric Dosing: Relative Bioavailability of Suspended Rifapentine and Isoniazid in an Open-Label Randomized Trial in Adults on Tuberculosis Preventive Therapy [0.03%]
利福平和异烟肼悬浮液的相对生物利用度：一项结核病预防治疗成人开标签盲随机试验
Saskia Janssen,Thanakorn Vongjarudech,Mats O Karlsson et al.
Saskia Janssen et al.
Background and objectives: The use of the 12-dose, once-weekly, rifapentine-based (3HP), short-course tuberculosis preventive treatment (TPT) in children has been limited due to a lack of child-friendly rifapentine formul...
Yuchen Guo,Jinqiu Yin,Sirin Yonucu et al.
Yuchen Guo et al.
Background and objectives: Diseases such as cystic fibrosis (CF) and non-CF bronchiectasis can cause extensive mucus formation in the lung, which may affect drug distribution and effects. As such, quantitative understandi...
Importance of Lysosomal Trapping and Plasmodium Parasite Infection on the Pharmacokinetics of Pyronaridine: A Physiologically Based Pharmacokinetic Model-Based Study [0.03%]
基于生理药代动力学模型的lysosome trapping和疟原虫感染对吡咯烷叮药代动力学的影响研究
Wan-Yu Chu,Wietse M Schouten,Hypolite Muhindo Mavoko et al.
Wan-Yu Chu et al.
Background and objective: Pyronaridine is a blood schizonticide with a high blood-to-plasma ratio, effective against Plasmodium parasites. As a lipophilic, moderately strong base, it accumulates in low-pH compartments suc...
A Physiologically Based Pharmacokinetic Model for the Prediction of Plasma and Bone Tissue Exposure after Prophylactic Administration of Ampicillin/Sulbactam in Patients with Osteonecrosis of the Jaw [0.03%]
一种基于生理的药代动力学模型预测颌骨坏死患者预防性使用氨苄西林/舒巴坦后的血浆和骨组织暴露量
Maximilian Stapf,Anton Straub,Valentin Steinacker et al.
Maximilian Stapf et al.
Background and objective: The combination of ampicillin (AMP) together with sulbactam (SBC) is a widely used choice for infection prophylaxis in the context of numerous surgical procedures, especially those performed in t...
Prediction of Maternal and Fetal Exposure to Escitalopram, Sertraline, and Paroxetine by Combining Human Ex Vivo Placenta Perfusion Data and Physiologically Based Pharmacokinetic Modeling [0.03%]
基于人体离体胎盘灌流数据和生理药动学模型预测艾斯西酞普兰、舍曲林及帕罗西汀对母体和胎儿的暴露风险
Laure-Hélène Préta,Naïm Bouazza,Frantz Foissac et al.
Laure-Hélène Préta et al.
Background: Depression is common in pregnant women, and selective serotonin reuptake inhibitors (SSRIs) are the most widely used antidepressants during pregnancy. Pregnancy is a period of major physiological changes that ...
Diego Maria Michele Fornasari
Diego Maria Michele Fornasari
Polyethylene glycols (PEGs) are inert polymers of repeating ethylene oxide subunits. Attaching PEGs to therapeutic proteins may reduce the protein's immunogenicity and antigenicity, improve solubility and stability, slow protein degradation...
Evaluation of Fentanyl-Emerged Adverse Events and Pharmacokinetics in Neonates: A Physiologically Based Pharmacokinetic Modeling Approach [0.03%]
基于生理的药代动力学模型在新生儿芬太尼不良反应及药代动力学评估中的应用研究
Walaa Yousef Bassyouni Mahdy,Kazuhiro Yamamoto,Risa Joji et al.
Walaa Yousef Bassyouni Mahdy et al.
Background: Despite its common use for analgesia in neonatal intensive care units, the optimal dosing and safety profile of fentanyl, particularly regarding suspected fentanyl-emerged adverse events (FEAEs), such as hypot...
Exposure-Response Analysis of Efsubaglutide Alfa in Patients with Type 2 Diabetes Treated with Metformin [0.03%]
艾本格鲁肽治疗二甲双胍继继疗法不佳的2型糖尿病患者：剂量反应分析
Qinghua Wang,Fan Jiang,Yulong Xu et al.
Qinghua Wang et al.
Background and objectives: Efsubaglutide alfa is a long-acting GLP-1 receptor agonist and is designed by fusion of two human GLP-1 molecules with IgG2 Fc via a natural immunoglobulin hinge region. This study evaluates the...
Population Pharmacokinetic Analysis of Balcinrenone in Healthy Participants and Participants with Heart Failure and Chronic Kidney Disease [0.03%]
依伏利酮在健康志愿者和心力衰竭合并慢性肾脏病患者中的群体药代动力学分析
Joanna Parkinson,Magnus Åstrand,Johanna Melin et al.
Joanna Parkinson et al.
Background and objective: Balcinrenone is a novel mineralocorticoid receptor modulator which, based on preclinical data, maintains cardio-renal benefits without increasing hyperkalemia risk. Balcinrenone is developed in c...
Modeling Whole-Body Dynamic PET Microdosing Data to Predict the Whole-Body Pharmacokinetics of Glyburide in Humans [0.03%]
基于全身动态微剂量PET数据的格列本脲人体药代动力学预测模型构建
Léa Comin,Solène Marie,Moreno Ursino et al.
Léa Comin et al.
Introduction: Whole-body dynamic (WB4D) positron emission tomography (PET) imaging data using radiolabeled analogs of drugs are mostly analyzed using descriptive approaches, with no relationship to traditional pharmacokin...