Real-Life Use of Subcutaneous Biologicals and JAK Inhibitors in IBD Maintenance Therapy: Treatment Continuation, Switching Patterns, and Concomitant Medications [0.03%]
真实生活中生物制剂及JAK抑制剂用于维持炎症性肠病治疗的继续、转换模式和联用药物分析
Mirkka Koivusalo,Jari Jokelainen,Anna Huhtinen et al.
Mirkka Koivusalo et al.
Objective: Combining biologicals or Janus kinase inhibitors (JAKis) with conventional medications and switching therapies is common in moderate-to-severe inflammatory bowel disease (IBD) treatment. This study assessed the...
Development and Validation of a Postoperative Delirium Prediction Model for Patients Undergoing Gastrointestinal Surgery [0.03%]
胃肠道手术患者术后谵妄预测模型的开发与验证
Zhihua Huang,Yang Deng,Qiang Li et al.
Zhihua Huang et al.
Background: Postoperative delirium (POD) is a critical and prevalent postoperative complication challenging to major surgeries, associated with the increased morbidity and mortality rate, prolonged hospitalization, and hi...
Research Progress on the Adaptation Law and Core Mechanism of Animal Models for Exercise Intervention in Inflammatory Bowel Disease: A Systematic Review [0.03%]
运动干预模型动物适应证候及核心机制的研究进展：系统性肠炎为例
Xiwen Yang,Sibin Yi
Xiwen Yang
Inflammatory Bowel Disease (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic recurrent intestinal inflammatory disorder with a rising global incidence and younger age trend. Current immunosuppressant-based trea...
Elettra Merola,Giovanni Mario Pes,David Yates Graham et al.
Elettra Merola et al.
Helicobacter pylori (H. pylori) is a human bacterial pathogen that causes one of the most common chronic bacterial infections worldwide. The microorganism has been classified by the International Agency for Research on Cancer as a Group I c...
Therapeutic Effects and Mechanisms of Faecalibacterium Prausnitzii in a Rat Model of Liver Cirrhosis [0.03%]
Faecalibacterium prausnitzii对肝硬化大鼠治疗效应及机制研究
Xinjun Hu,Chengyu Ma,Bingyou Yin et al.
Xinjun Hu et al.
Background and aims: Liver cirrhosis development is often accompanied by dysbiosis of the intestinal flora. As an important component of the human intestinal microflora, Faecalibacterium prausnitzii plays an important rol...
Multi-Components in Modified Tongyou Decoction Targeting Akt/mTOR to Modulate Esophageal Cancer Cell Autophagy via Network Pharmacology Integrated with Experimental Verification [0.03%]
基于网络药理学的 tongyou 汤加减方多成分调控食管癌细胞自噬的活性及其对 akt/mtor 信号通路的影响研究
Yingying Tian,Jing Zhang,Yueyue Yu et al.
Yingying Tian et al.
Objective: To identify active components of Modified Tongyou Decoction (MTD) acting on esophageal cancer (EC) cell autophagy and their potential targets on Akt/mTOR pathway via network pharmacology integrated with experim...
Management and Treatment of Perianal Fistulizing Crohn's Disease [0.03%]
periAnalytics肛周瘘管性克罗恩病的管理和治疗
Joseph J Lee,Amy L Lightner
Joseph J Lee
Perianal fistulizing Crohn's disease is a severe and disabling phenotype of Crohn's disease, affecting up to one-third of Crohn's patients. This phenotype can result in significant quality of life impairment in quality of life due to chroni...
Chemopreventive Effects of Statins and Aspirin on Colorectal Cancer Among Patients with Inflammatory Bowel Disease: Evidence of a Synergistic Association from a Large Cohort [0.03%]
他汀类和阿司匹林联合用药对炎症性肠病患者结直肠癌的预防效果：一项大规模队列研究的新证据
Joelle Sleiman,Christopher Khouri,Un Jung Lee et al.
Joelle Sleiman et al.
Background: Patients with Inflammatory Bowel Disease (IBD) are at an increased risk of developing colorectal cancer (CRC). While numerous studies have explored chemoprevention strategies in the general population, the spe...
Challenges in the Management of Inflammatory Bowel Disease in Children: A Narrative Review [0.03%]
儿童炎症性肠病管理面临的挑战：叙述性综述
Wathsala Hathagoda,Shaman Rajindrajith,Madunil Anuk Niriella
Wathsala Hathagoda
There is a rising prevalence of pediatric inflammatory bowel disease (PIBD) worldwide. This article aims to explore the key issues in managing PIBD and attempts to propose evidence-based recommendations. We reviewed published literature on ...
Metabolic-Behavioral Risk Factors for Colorectal Adenomatous Polyps in Young Adults [0.03%]
青年成人结直肠腺瘤的代谢行为危险因素分析
Quan Zheng,Zaizai Li,Jiangtian Hu et al.
Quan Zheng et al.
Objective: This study aimed to identify risk factors associated with colorectal adenomatous polyps in young adults (≤40 years) to support early prevention and screening strategies for colorectal cancer. ...