Elettra Merola,Giovanni Mario Pes,David Yates Graham et al.
Elettra Merola et al.
Helicobacter pylori (H. pylori) is a human bacterial pathogen that causes one of the most common chronic bacterial infections worldwide. The microorganism has been classified by the International Agency for Research on Cancer as a Group I c...
Therapeutic Effects and Mechanisms of Faecalibacterium Prausnitzii in a Rat Model of Liver Cirrhosis [0.03%]
Faecalibacterium prausnitzii对肝硬化大鼠治疗效应及机制研究
Xinjun Hu,Chengyu Ma,Bingyou Yin et al.
Xinjun Hu et al.
Background and aims: Liver cirrhosis development is often accompanied by dysbiosis of the intestinal flora. As an important component of the human intestinal microflora, Faecalibacterium prausnitzii plays an important rol...
Multi-Components in Modified Tongyou Decoction Targeting Akt/mTOR to Modulate Esophageal Cancer Cell Autophagy via Network Pharmacology Integrated with Experimental Verification [0.03%]
基于网络药理学的 tongyou 汤加减方多成分调控食管癌细胞自噬的活性及其对 akt/mtor 信号通路的影响研究
Yingying Tian,Jing Zhang,Yueyue Yu et al.
Yingying Tian et al.
Objective: To identify active components of Modified Tongyou Decoction (MTD) acting on esophageal cancer (EC) cell autophagy and their potential targets on Akt/mTOR pathway via network pharmacology integrated with experim...
Management and Treatment of Perianal Fistulizing Crohn's Disease [0.03%]
periAnalytics肛周瘘管性克罗恩病的管理和治疗
Joseph J Lee,Amy L Lightner
Joseph J Lee
Perianal fistulizing Crohn's disease is a severe and disabling phenotype of Crohn's disease, affecting up to one-third of Crohn's patients. This phenotype can result in significant quality of life impairment in quality of life due to chroni...
Chemopreventive Effects of Statins and Aspirin on Colorectal Cancer Among Patients with Inflammatory Bowel Disease: Evidence of a Synergistic Association from a Large Cohort [0.03%]
他汀类和阿司匹林联合用药对炎症性肠病患者结直肠癌的预防效果：一项大规模队列研究的新证据
Joelle Sleiman,Christopher Khouri,Un Jung Lee et al.
Joelle Sleiman et al.
Background: Patients with Inflammatory Bowel Disease (IBD) are at an increased risk of developing colorectal cancer (CRC). While numerous studies have explored chemoprevention strategies in the general population, the spe...
Challenges in the Management of Inflammatory Bowel Disease in Children: A Narrative Review [0.03%]
儿童炎症性肠病管理面临的挑战：叙述性综述
Wathsala Hathagoda,Shaman Rajindrajith,Madunil Anuk Niriella
Wathsala Hathagoda
There is a rising prevalence of pediatric inflammatory bowel disease (PIBD) worldwide. This article aims to explore the key issues in managing PIBD and attempts to propose evidence-based recommendations. We reviewed published literature on ...
Metabolic-Behavioral Risk Factors for Colorectal Adenomatous Polyps in Young Adults [0.03%]
青年成人结直肠腺瘤的代谢行为危险因素分析
Quan Zheng,Zaizai Li,Jiangtian Hu et al.
Quan Zheng et al.
Objective: This study aimed to identify risk factors associated with colorectal adenomatous polyps in young adults (≤40 years) to support early prevention and screening strategies for colorectal cancer. ...
Optimising Monoclonal Antibody Drug Development for Inflammatory Bowel Disease [0.03%]
优化单克隆抗体药物开发以治疗炎症性肠病
Michael Colwill,Sailish Honap,Silvio Danese et al.
Michael Colwill et al.
Despite the success of monoclonal antibody (mAb) therapies in treating inflammatory bowel disease (IBD), a persistent therapeutic ceiling remains. This comprehensive review explores emerging strategies to enhance the efficacy of mAb-based t...
Colonic Mucosal Gene Expression Profile in Patients with Neoplastic Progression in Longstanding Ulcerative Colitis [0.03%]
长期溃疡性结肠炎患者肿瘤进展的结肠黏膜基因表达谱特征分析
Lene Alsøe,Stephan Andreas Brackmann,Yohan Lefol et al.
Lene Alsøe et al.
Purpose: Long-standing mucosal inflammation is suspected to be one of the main drivers of colitis-associated colorectal cancer (CA-CRC), but far from all colitis patients develop cancer. Non-neoplastic mucosa located dist...
Panenteric Capsule Endoscopy in Young Patients with Suspected Irritable Bowel Syndrome: A Self-Controlled Feasibility Study [0.03%]
怀疑患肠易激综合征的年轻患者全小肠胶囊内镜检查自我对照可行性研究
Robert Benamouzig,Walaa El Arja,Bakthiar Bejou et al.
Robert Benamouzig et al.
Objective: Although the diagnosis of irritable bowel syndrome (IBS) is based on clinical criteria, a colonoscopy is often performed to rule out alternative digestive disorders. The panenteric PillCam™ Crohn's capsule, wh...