Chemopreventive Effects of Statins and Aspirin on Colorectal Cancer Among Patients with Inflammatory Bowel Disease: Evidence of a Synergistic Association from a Large Cohort [0.03%]
他汀类和阿司匹林联合用药对炎症性肠病患者结直肠癌的预防效果：一项大规模队列研究的新证据
Joelle Sleiman,Christopher Khouri,Un Jung Lee et al.
Joelle Sleiman et al.
Background: Patients with Inflammatory Bowel Disease (IBD) are at an increased risk of developing colorectal cancer (CRC). While numerous studies have explored chemoprevention strategies in the general population, the spe...
Challenges in the Management of Inflammatory Bowel Disease in Children: A Narrative Review [0.03%]
儿童炎症性肠病管理面临的挑战：叙述性综述
Wathsala Hathagoda,Shaman Rajindrajith,Madunil Anuk Niriella
Wathsala Hathagoda
There is a rising prevalence of pediatric inflammatory bowel disease (PIBD) worldwide. This article aims to explore the key issues in managing PIBD and attempts to propose evidence-based recommendations. We reviewed published literature on ...
Metabolic-Behavioral Risk Factors for Colorectal Adenomatous Polyps in Young Adults [0.03%]
青年成人结直肠腺瘤的代谢行为危险因素分析
Quan Zheng,Zaizai Li,Jiangtian Hu et al.
Quan Zheng et al.
Objective: This study aimed to identify risk factors associated with colorectal adenomatous polyps in young adults (≤40 years) to support early prevention and screening strategies for colorectal cancer. ...
Optimising Monoclonal Antibody Drug Development for Inflammatory Bowel Disease [0.03%]
优化单克隆抗体药物开发以治疗炎症性肠病
Michael Colwill,Sailish Honap,Silvio Danese et al.
Michael Colwill et al.
Despite the success of monoclonal antibody (mAb) therapies in treating inflammatory bowel disease (IBD), a persistent therapeutic ceiling remains. This comprehensive review explores emerging strategies to enhance the efficacy of mAb-based t...
Colonic Mucosal Gene Expression Profile in Patients with Neoplastic Progression in Longstanding Ulcerative Colitis [0.03%]
长期溃疡性结肠炎患者肿瘤进展的结肠黏膜基因表达谱特征分析
Lene Alsøe,Stephan Andreas Brackmann,Yohan Lefol et al.
Lene Alsøe et al.
Purpose: Long-standing mucosal inflammation is suspected to be one of the main drivers of colitis-associated colorectal cancer (CA-CRC), but far from all colitis patients develop cancer. Non-neoplastic mucosa located dist...
Panenteric Capsule Endoscopy in Young Patients with Suspected Irritable Bowel Syndrome: A Self-Controlled Feasibility Study [0.03%]
怀疑患肠易激综合征的年轻患者全小肠胶囊内镜检查自我对照可行性研究
Robert Benamouzig,Walaa El Arja,Bakthiar Bejou et al.
Robert Benamouzig et al.
Objective: Although the diagnosis of irritable bowel syndrome (IBS) is based on clinical criteria, a colonoscopy is often performed to rule out alternative digestive disorders. The panenteric PillCam™ Crohn's capsule, wh...
Patatin-Like Phospholipase Domain-Containing Protein 3 (PNPLA3) rs738409 Variant and Non-Alcoholic Fatty Liver Disease Risk in Vietnamese Working-Age Adults: A Case-Control Study with Metabolic Insights [0.03%]
Patatin样磷脂酶结构域含3蛋白多态型与越南劳动年龄成人非酒精性脂肪肝病风险：一项代谢机制病例对照研究
Ha Minh Nguyen,Duong Hoang Huy Le,Thinh Hung Nguyen et al.
Ha Minh Nguyen et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is an increasing public health concern in Vietnam, particularly among working-age adults (18-60 years). The PNPLA3 rs738409 variant (C>G) is a well-established risk fa...
Characterization of Bacterial Biofilm Composition in Occluded Plastic Biliary Stents [0.03%]
塑料胆道支架堵塞的细菌生物被膜组成特征分析
Victor Kalil Flumignan,Marcelo Palma Sircili,Lígia Garcia Germano et al.
Victor Kalil Flumignan et al.
Purpose: Plastic biliary stents are an effective treatment for biliary obstruction. Despite being resolutive and accessible, they are known to have a low patency rate, estimated at 3 to 6 months. This can be attributed to...
Serological Markers of Intestinal Barrier Function and Inflammation as Potential Predictors of Recurrent Primary Sclerosing Cholangitis [0.03%]
肠屏障功能和炎症的血清学标志物可能预测原发性硬化性胆管炎复发的风险
Mojmir Hlavaty,Jan Brezina,Tetiana Osadcha et al.
Mojmir Hlavaty et al.
The impairment of intestinal barrier function is implicated in primary sclerosing cholangitis, but the clinical evidence is scarce. Therefore, we performed a cross-sectional study to evaluate serological markers of inflammation and intestin...
Clinically Adult-Onset Nesidioblastosis with Repeated Severe Hypoglycemia, Successfully Treated by Two Times Pancreatectomies. A Rare Case Report [0.03%]
临床迟发性Nesidioblastosis反复严重低血糖经两次手术成功治疗的罕见病例报告
Wataru Izumo,Ryota Higuchi,Masahiro Shiihara et al.
Wataru Izumo et al.
Although nesidioblastosis is the most common cause of hyperinsulinemic hypoglycemia in infants, it is rare in adults. Nesidioblastosis is pathologically characterized by diffuse neoformation of the islets of Langerhans islets from the pancr...