Computational evaluation of natural compounds as potential inhibitors of human PEPCK-M: an alternative for lung cancer therapy [0.03%]
人PEPCK-M计算评估作为潜在的天然化合物抑制剂：肺癌治疗的替代方法
Luiz Phillippe R Baptista,Vanessa Vc Sinatti,Joao Hm Da Silva et al.
Luiz Phillippe R Baptista et al.
Background: Lung cancer is the leading cause of cancer-related death worldwide. Among its subtypes, non-small cell lung cancer (NSCLC) is the most common. Recently, the mitochondrial isoform of the enzyme phosphoenolpyruv...
Molecular dynamics study to improve the substrate adsorption of Saccharomycopsis fibuligera R64 alpha-amylase by designing a new surface binding site [0.03%]
设计新表面结合位点以提高稻 Fibuligera R64α淀粉酶底物吸附的分子动力学研究
Umi Baroroh,Muhammad Yusuf,Saadah Diana Rachman et al.
Umi Baroroh et al.
Background: Carbohydrate binding module (CBM) and surface binding site (SBS) are two important parts of amylase which respond to the raw starch digestion. They are related to the enzyme ability to adsorb and to catalyze the starch hydrolysi...
Computational analysis of ligand-receptor interactions in wild-type and mutant erythropoietin complexes [0.03%]
野生型和突变型促红细胞生成素复合物的配体-受体相互作用的计算分析
Nicholas J Pekas,Samuel S Newton
Nicholas J Pekas
Background: Erythropoietin (EPO), a pleiotropic cytokine, binds to its receptor (EPOR) in bone marrow, activating a signaling cascade that results in red blood cell proliferation. A recently discovered naturally occurring...
Structural and functional characterization of the Helicobacter pylori cytidine 5'-monophosphate-pseudaminic acid synthase PseF: molecular insight into substrate recognition and catalysis mechanism [0.03%]
Helicobacter pylori假尿苷酸合成酶PseF的结构与功能表征：底物识别及催化机制的分子见解
Syeda Umme Habiba Wahid
Syeda Umme Habiba Wahid
The bacterium Helicobacter pylori is a human gastric pathogen that can cause a wide range of diseases, including chronic gastritis, peptic ulcer and gastric carcinoma. It is classified as a definitive (class I) human carcinogen by the Inter...
Computational tool for optimizing the essential oils utilization in inhibiting the bacterial growth [0.03%]
一种用于优化抑菌精油的使用量的计算工具
Noha E El-Attar,Wael A Awad
Noha E El-Attar
Day after day, the importance of relying on nature in many fields such as food, medical, pharmaceutical industries, and others is increasing. Essential oils (EOs) are considered as one of the most significant natural products for use as ant...
Prioritizing single-nucleotide polymorphisms and variants associated with clinical mastitis [0.03%]
与临床乳腺炎相关的单核苷酸多态性及变异的优先排序
Prashanth Suravajhala,Alfredo Benso
Prashanth Suravajhala
Next-generation sequencing technology has provided resources to easily explore and identify candidate single-nucleotide polymorphisms (SNPs) and variants. However, there remains a challenge in identifying and inferring the causal SNPs from ...
The identification of protein domains that mediate functional interactions between Rab-GTPases and RabGAPs using 3D protein modeling [0.03%]
基于三维蛋白质模型的Rab-GTP酶和RabGAP之间功能相互作用鉴定研究：识别介导蛋白域
Jeremiah J Davie,Silviu L Faitar
Jeremiah J Davie
Currently, time-consuming serial in vitro experimentation involving immunocytochemistry or radiolabeled materials is required to identify which of the numerous Rab-GTPases (Rab) and Rab-GTPase activating proteins (RabGAP) are capable of fun...
Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C [0.03%]
产生Actinomycin X的Streptomyces antibioticus IMRU 3720和产生Actinomycin C的Streptomyces chrysomallus ATCC11523中actinomycin生物合成基因簇的遗传关系
Ivana Crnovčić,Christian Rückert,Siamak Semsary et al.
Ivana Crnovčić et al.
Sequencing the actinomycin (acm) biosynthetic gene cluster of Streptomyces antibioticus IMRU 3720, which produces actinomycin X (Acm X), revealed 20 genes organized into a highly similar framework as in the bi-armed acm C biosynthetic gene ...
Raju Dash,Rasel Das,Md Junaid et al.
Raju Dash et al.
Ebola virus (EBOV) is one of the lethal viruses, causing more than 24 epidemic outbreaks to date. Despite having available molecular knowledge of this virus, no definite vaccine or other remedial agents have been developed yet for the manag...
Mapping circulating serum miRNAs to their immune-related target mRNAs [0.03%]
基于循环血液小RNA的免疫相关靶基因网络研究
Bakhtiyor Nosirov,Joël Billaud,Alexis Vandenbon et al.
Bakhtiyor Nosirov et al.
Purpose: Evidence suggests that circulating serum microRNAs (miRNAs) might preferentially target immune-related mRNAs. If this were the case, we hypothesized that immune-related mRNAs would have more predicted serum miRNA...