Physical Exercise as Kynurenine Pathway Modulator in Chronic Diseases: Implications for Immune and Energy Homeostasis [0.03%]
运动通过调控犬尿氨酸代谢通路在慢性疾病中对免疫和能量稳态的影响
Niklas Joisten,David Walzik,Alan J Metcalfe et al.
Niklas Joisten et al.
Emerging evidence highlights the substantial role of the kynurenine pathway in various physiological systems and pathological conditions. Physical exercise has been shown to impact the kynurenine pathway in response to both single (acute) a...
Potential Role of Neuroactive Tryptophan Metabolites in Central Fatigue: Establishment of the Fatigue Circuit [0.03%]
神经活性 tryptophan 代谢物在中枢疲劳中的潜在作用：建立疲劳电路
Masatoshi Yamashita
Masatoshi Yamashita
Central fatigue leads to reduced ability to perform mental tasks, disrupted social life, and impaired brain functions from childhood to old age. Regarding the neurochemical mechanism, neuroactive tryptophan metabolites are thought to play k...
Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and Disease [0.03%]
肠菌-肠-脑轴中的色氨酸代谢物：一种影响肠道健康与疾病的跨界通讯系统
Annalisa Bosi,Davide Banfi,Michela Bistoletti et al.
Annalisa Bosi et al.
The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis, and different immune, hormonal, and neuronal signals participate to this interkingdom communication system between eukaryota and prokaryota. The essen...
Plasma Serotonin in Laying Hens (Gallus gallus domesticus) With and Without Foot pad Dermatitis [0.03%]
伴有和不伴有足垫炎的产蛋鸡(Gallus gallus domesticus)血浆血清素水平研究
Daniela Alberghina,Vito Biondi,Annamaria Passantino et al.
Daniela Alberghina et al.
The aim of this study was to investigate whether plasma serotonin (5-hydroxytryptamine [5-HT]) was associated with the presence of foot pad dermatitis (FPD) in laying hens. FPD birds (n = 20) and healthy individuals (n = 22) were included. ...
David B Ramsden,Rosemary H Waring,Richard B Parsons et al.
David B Ramsden et al.
Single-nucleotide polymorphisms (SNPs) in and around the nicotinamide N-methyltransferase (NNMT) gene are associated with a range of cancers and other diseases and conditions. The data on these associations have been assembled, and their st...
Monica Borghi,Matteo Puccetti,Marilena Pariano et al.
Monica Borghi et al.
Amino acid catabolism occurs during inflammation and regulates innate and adaptive immunity. The role of commensal bacteria in amino acid catabolism and the production of metabolites able to regulate the development and function of the inna...
Adrian C Williams,Lisa J Hill
Adrian C Williams
Nicotinamide homeostasis is a candidate common denominator to explain smooth transitions, whether demographic, epidemiological or economic. This 'NAD world', dependent on hydrogen-based energy, is not widely recognised as it is neither meas...
Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937 [0.03%]
诱导人单核细胞白血病/淋巴瘤细胞系THP-1和U937中色氨酸2，3-双氧酶的表达
Delia Hoffmann,Luc Pilotte,Vincent Stroobant et al.
Delia Hoffmann et al.
Tumor-associated macrophages are immune cells with diverse functions in tumor development. Among other functions, they downregulate immune-mediated tumor rejection by depriving lymphocytes of nutrients. The essential amino acid tryptophan i...
Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice [0.03%]
脂多糖增加小鼠皮质犬尿酸和参照记忆缺陷
Lee Peyton,Alfredo Oliveros,Maximilian Tufvesson-Alm et al.
Lee Peyton et al.
Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of N-methyl-d-aspartate (NMDA) receptors. Kynurenic acid levels are in...
Tryptophan Metabolism as Source of New Prognostic Biomarkers for FAP Patients [0.03%]
色氨酸代谢作为FAP患者新的预后生物标志物来源
Sara Crotti,Chiara Bedin,Antonella Bertazzo et al.
Sara Crotti et al.
Familial adenomatous polyposis (FAP), a common inherited form of colorectal cancer (CRC), causes the development of hundreds to thousands of colonic adenomas in the colorectum beginning in early adolescence. In absence of a prophylactic sur...